408-38-8

Basic information

• Product Name: 1-FLUOROHEXADECANE
• Synonyms: 1-FLUOROHEXADECANE;hexadecane,1-fluoro-;Hexadecyl fluoride
• CAS NO: 408-38-8
• Molecular Formula: C₁₆H₃₃F
• Molecular Weight: 244.43
• EINECS: 206-989-7
• Mol File: 408-38-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 18°C
• Boiling Point: 322.92°C (estimate)
• Flash Point: 225.6°C
• Appearance: /
• Density: 0.8542
• Vapor Pressure: 0.00394mmHg at 25°C
• Refractive Index: 1.4382
• CAS DataBase Reference: 1-FLUOROHEXADECANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-FLUOROHEXADECANE(408-38-8)
• EPA Substance Registry System: 1-FLUOROHEXADECANE(408-38-8)

Safety Data

• Hazardous Substances Data: 408-38-8(Hazardous Substances Data)

Usage

Description

1-Fluorohexadecane, a synthetic compound with the chemical formula C16H33F, is a fluorinated derivative of hexadecane, a saturated hydrocarbon. The fluorine substitution in this compound endows it with unique properties, such as high hydrophobicity and thermal stability, making it valuable in material science, nanotechnology, and the development of advanced materials and technologies.

Uses

Used in Research and Development:
1-Fluorohexadecane is used as a research compound for the development of new materials and technologies, taking advantage of its unique properties and fluorine substitution.
Used in Surfactant Production:
1-Fluorohexadecane is used as a surfactant in various industries, such as cosmetics and pharmaceuticals, due to its high hydrophobicity and ability to reduce surface tension between different substances.
Used in Lubricant Production:
1-Fluorohexadecane is used as a lubricant in various applications, such as in machinery and automotive industries, because of its thermal stability and ability to reduce friction between moving parts.
Used in Pharmaceutical Industry:
1-Fluorohexadecane is used as a pharmaceutical compound for the synthesis of new drugs and as a carrier for drug delivery systems, leveraging its unique properties to improve drug efficacy and bioavailability.
Used as a Chemical Intermediate:
1-Fluorohexadecane is used as a chemical intermediate in the synthesis of other organic compounds, contributing to the development of new chemical products and processes.
Used in Self-Assembled Monolayers for Surface Modification:
1-Fluorohexadecane is used in the creation of self-assembled monolayers for surface modification, allowing for the alteration of surface properties for various applications, such as in sensors, catalysts, and medical devices.

InChI:InChI=1/C16H33F/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h2-16H2,1H3

Upstream product

• 6068-28-6 tosylate de n-hexadecyle 
• 41320-44-9 O-hexadecyl, S-methyl dithiocarbonate 
• 16415-12-6 hexadecyltrimethoxysilane 
• 36653-82-4 1-Hexadecanol 
• 56-23-5 tetrachloromethane 
• 544-76-3 Hexadecane 
• 112-82-3 hexadecanyl bromide 
• 66143-64-4 (3-hexadecyloxysulfonyl-propyl)-trimethyl-ammonium; fluoride 
• 629-27-6 1-Iodooctane 
• 85577-56-6 S,S-diethyl-S-3-<(hexadecyloxy)sulfonyl>propylsulfonium fluoride 

Relevant articles and documents

Reactivity study of 1,1,2,4,4,5,7,7,8,8,9,9,-tridecafluoro-5- trifluoromethyl-3,6-dioxanon-1-ene in nucleophilic reactions: Fluorination properties of secondary amine adducts

A series of nucleophiles was reacted with (1) as a representative of perfluoro(alkyl vinyl ethers). All reactions were completely regioselective with the nucleophilic attack at the terminal carbon atom. Reactions of hydroxy compounds, thiols and sec-amines afforded addition products, but butyllithium, tributylphosphane or complex hydrides caused displacement of vinylic fluorine: butyllithium afforded cis-derivative, while reactions with hydrides and the phosphane led to mixtures of cis- and trans-derivatives. Diethylamine and piperidine adducts displayed the property to substitute hydroxyl for fluorine in hexadecan-1-ol. Molecular properties of hexafluoropropene and perfluoro(methyl vinyl ether) were calculated by ab initio method at the MP2/6-311G(d,p) level of theory and their impact on relative reactivity was estimated.

Rapid Deoxyfluorination of Alcohols with N-Tosyl-4-chlorobenzenesulfonimidoyl Fluoride (SulfoxFluor) at Room Temperature

The deoxyfluorination of alcohols is a fundamentally important approach to access alkyl fluorides, and thus the development of shelf-stable, easy-to-handle, fluorine-economical, and highly selective deoxyfluorination reagents is highly desired. This work describes the development of a crystalline compound, N-tosyl-4-chlorobenzenesulfonimidoyl fluoride (SulfoxFluor), as a novel deoxyfluorination reagent that possesses all of the aforementioned merits, which is rare in the arena of deoxyfluorination. Endowed by the multi-dimensional modulating ability of the sulfonimidoyl group, SulfoxFluor is superior to 2-pyridinesulfonyl fluoride (PyFluor) in fluorination rate, and is also superior to perfluorobutanesulfonyl fluoride (PBSF) in fluorine-economy. Its reaction with alcohols not only tolerates a wide range of functionalities including the more sterically hindered alcoholic hydroxyl groups, but also exhibits high fluorination/elimination selectivity. Because SulfoxFluor can be easily prepared from inexpensive materials and can be safely handled without special techniques, it promises to serve as a practical deoxyfluorination reagent for the synthesis of various alkyl fluorides.

Hydrated tetrabutylammonium fluoride as a powerful nucleophilic fluorinating agent

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