4075-58-5

Basic information

• Product Name: ETHYL THIOPHENE-2-GLYOXYLATE
• Synonyms: ETHYL 2-THENOYLFORMATE;ETHYL 2-OXO-2-(2-THIENYL)ACETATE;ETHYL THIOPHENE-2-GLYOXYLATE;2-THIOPHENE GLYOXYLIC ACID ETHYL ESTER;OXO-THIOPHEN-2-YL-ACETIC ACID ETHYL ESTER;ethyl alpha-oxothiophen-2-acetate;2-Thiophene Glyoxalicacid Ethyl Ester;Ethyl 2-thiophene glyoxylate, GC 96%
• CAS NO: 4075-58-5
• Molecular Formula: C₈H₈O₃S
• Molecular Weight: 184.21
• EINECS: 223-793-7
• Product Categories: Thiophene&Benzothiophene
• Mol File: 4075-58-5.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 102-110 °C (0.8 mmHg)
• Flash Point: >110°C
• Appearance: clear yellow to brown liquid
• Density: 1.25
• Refractive Index: 1.543-1.549
• Storage Temp.: 2-8°C(protect from light)
• Solubility: Difficult to mix.
• BRN: 5651
• CAS DataBase Reference: ETHYL THIOPHENE-2-GLYOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL THIOPHENE-2-GLYOXYLATE(4075-58-5)
• EPA Substance Registry System: ETHYL THIOPHENE-2-GLYOXYLATE(4075-58-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-36
• Hazardous Substances Data: 4075-58-5(Hazardous Substances Data)

Usage

Description

ETHYL THIOPHENE-2-GLYOXYLATE is a clear yellow to brown liquid that is utilized in various applications across different industries due to its unique chemical properties.

Uses

Used in Drug Discovery:
ETHYL THIOPHENE-2-GLYOXYLATE is used as a compound for drug discovery, particularly through chemic informatics-based design. Its unique chemical structure allows for the development of potential therapeutic agents and contributes to the advancement of pharmaceutical research.
Used as a Catalyst:
In the chemical industry, ETHYL THIOPHENE-2-GLYOXYLATE serves as a catalyst, facilitating various chemical reactions and improving the efficiency of production processes. Its catalytic properties make it a valuable component in the synthesis of different compounds.
Used in Synthesis of Raw Material:
ETHYL THIOPHENE-2-GLYOXYLATE is also employed in the synthesis of raw materials, which are essential for the production of various products in the chemical and pharmaceutical industries. Its role in the synthesis process highlights its importance in the development of new materials and compounds with potential applications in multiple sectors.

Upstream product

• 188290-36-0 thiophene 
• 4755-77-5 Ethyl oxalyl chloride 
• 4075-59-6 2-thiopheneglyoxylic acid 
• 541-41-3 chloroformic acid ethyl ester 
• 5713-61-1 thiophen-2-yl magnesium bromide 
• 95-92-1 oxalic acid diethyl ester 
• 54663-78-4 tributyl(thien-2-yl)stannane 
• 64-17-5 ethanol 
• 872-55-9 2-ethylthiophene 
• 141-78-6 ethyl acetate 
• 33898-90-7 2-Thenoylacetonitrile 
• 57382-97-5 ethyl thiophen-2-ylacetate 
• 1003-09-4 2-bromothiophene 
• 82219-12-3 ethyl 2-(thiophen-2-yl)acetimidate hydrochloride 

Downstream Products

• 28569-78-0 hydroxy-phenyl-[2]thienyl-acetic acid ethyl ester 
• 28569-88-2 Ethyl (2,2'-Dithienyl)glycolate 
• 64532-10-1 3-(thiophen-2-yl)quinoxalin-2(1H)-one 
• 86582-52-7 N-benzyl-2-oxo-2-(thiophen-2-yl)acetamide 
• 4075-59-6 2-thiopheneglyoxylic acid 
• 89481-60-7 ethyl 2-(4-methoxyphenylimino)-2-(thiophen-2-yl)acetate 
• 4746-63-8 2-hydroxy-2,2-di(thiophen-2-yl)acetic acid 
• 78196-89-1 (5-Phenyl-2-thienyl)(2-thienyl)acetic acid 
• 4408-82-6 2,2-di(thiophen-2-yl)acetic acid 
• 28560-51-2 2-hydroxy-2-phenyl-2-(thiophen-2-yl)acetic acid 
• 89008-59-3 2-Hydroxy-3-phenyl-2-(2-thienyl)propansaeure 
• 64471-60-9 2-Cyclohexyl-2-(2-thienyl)glykolsaeure 
• 91902-78-2 (+/-)-3-phenyl-2-[2]thienyl-propionic acid 
• 519163-93-0 (E)-ethyl 2-(4-methoxyphenylimino)-2-(thiophen-2-yl)acetate 

Relevant articles and documents

Stereoselective Synthesis of Dihydrocoumarins via [1,2]-Phospha-Brook Rearrangement in Three-Component Coupling Reaction of α-Ketoesters, o-Quinone Methides, and Dialkyl Phosphites

A highly regio- and diastereoselective approach for the synthesis of phosphate substituted dihydrocoumarins via Br?nsted base catalyzed [1,2]-phospha-Brook rearrangement is reported. The two-step, one-pot Michael addition of α-phosphonyloxy enolates proceeds by coupling of dialkyl phosphite and α-ketoesters to o-quinone methides, followed by an intramolecular cyclization, providing 3,4-dihydrocoumarin frameworks.

Chemo- And diastereoselective synthesis of pyrrolidines from aroylformates and δ-tosylamino enones via P(NMe2)3-mediated reductive amination/base-catalyzed michael addition cascade

A novel P(NMe2)3-mediated tandem (1 + 4) annulation between aroylformates and δ-tosylamino enones has been developed that affords a facile synthesis of functionalized pyrrolidines in moderate to excellent yields with exclusive chemoselectivity and high diastereoselectivity. Mechanistic investigation reveals that the reaction proceeds through an unprecedented P(NMe2)3-mediated reductive amination/base-catalyzed Michael addition cascade. The reaction herein also represents the first study of the reactivity patterns of the Kukhtin-Ramirez adducts toward ambiphilic nucleophile-electrophiles.

Diastereo- and Enantioselective Synthesis of Fluorine Motifs with Two Contiguous Stereogenic Centers

The synthesis of chiral fluorine containing motifs, in particular, chiral fluorine molecules with two contiguous stereogenic centers, has attracted much interest in research due to the limited number of methods available for their preparation. Herein, we report an atom-economical and highly stereoselective synthesis of chiral fluorine molecules with two contiguous stereogenic centers via azabicyclo iridium-oxazoline-phosphine-catalyzed hydrogenation of readily available vinyl fluorides. Various aromatic, aliphatic, and heterocyclic systems with a variety of functional groups were found to be compatible with the reaction and provide the highly desirable product as single diastereomers with excellent enantioselectivities.