407-62-5 Usage
Description
5,5,5-Trifluoropentanoic acid, also known as 5,5,5-Trifluorovaleric acid, is a synthetic organic compound characterized by the presence of three fluorine atoms attached to the pentanoic acid backbone. This unique structure endows it with distinctive chemical properties, making it a versatile building block in various applications.
Uses
Used in Biochemistry:
5,5,5-Trifluoropentanoic acid is used as a fluorinating agent in the modification of mammalian cell surfaces. It targets the sialic acid biosynthetic pathway, allowing for the introduction of fluorine atoms into cell surface glycoproteins and glycolipids. This modification can be utilized for various research purposes, such as studying cell-cell interactions, immune responses, and the development of novel therapeutic agents.
Used in Coordination Chemistry:
In the field of coordination chemistry, 5,5,5-Trifluoropentanoic acid serves as a ligand for the synthesis of paddlewheel copper fluorinated alkyl/aryl carboxylate complexes. These complexes exhibit unique structural and electronic properties, which make them valuable for applications in catalysis, materials science, and as potential pharmaceutical agents. The incorporation of the trifluoromethyl group into these complexes can modulate their reactivity, stability, and selectivity, opening up new avenues for their use in various chemical transformations.
Check Digit Verification of cas no
The CAS Registry Mumber 407-62-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,0 and 7 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 407-62:
(5*4)+(4*0)+(3*7)+(2*6)+(1*2)=55
55 % 10 = 5
So 407-62-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H7F3O2/c6-5(7,8)3-1-2-4(9)10/h1-3H2,(H,9,10)
407-62-5Relevant articles and documents
Direct C(sp3)?H Trifluoromethylation of Unactivated Alkanes Enabled by Multifunctional Trifluoromethyl Copper Complexes
Choi, Geunho,Lee, Geun Seok,Park, Beomsoon,Kim, Dongwook,Hong, Soon Hyeok
supporting information, p. 5467 - 5474 (2021/01/20)
A mild and operationally simple C(sp3)?H trifluoromethylation method was developed for unactivated alkanes by utilizing a bench-stable CuIII complex, bpyCu(CF3)3, as the initiator of the visible-light photoinduced reaction, the source of a trifluoromethyl radical as a hydrogen atom transfer reagent, and the source of a trifluoromethyl anion for functionalization. The reaction was initiated by the generation of reactive electrophilic carbon-centered CF3 radical through photoinduced homolytic cleavage of bpyCu(CF3)3, followed by hydrogen abstraction from an unactivated C(sp3)?H bond. Comprehensive mechanistic investigations based on a combination of experimental and computational methods suggested that C?CF3 bond formation was enabled by radical–polar crossover and ionic coupling between the resulting carbocation intermediate and the anionic CF3 source. The methylene-selective reaction can be applied to the direct, late-stage trifluoromethylation of natural products and bioactive molecules.
Pyrazolo[3,4-b]pyridine carboxylic acid esters and their pharmaceutical use
-
, (2008/06/13)
Compounds of the formula (I): STR1 wherein R1, R3, R4, R5 and R6 have defined values and the N-oxides at the 7-position of the pyrazolo[3,4-b]pyridine ring system and the pharmaceutically-acceptable acid-addition salts thereof, processes for their preparation and use, pharmaceutical compositions, and intermediates for preparing said compounds of the formula (I). The compounds of formula (I) are central nervous system depressants, for example anxiolytic agents.
