4065-45-6 Usage
Description
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid, also known as Sulisobenzone, is a broad-spectrum organic UV filter commonly used in sunscreen formulations. It is known for its ability to absorb harmful UV light, protecting formulations from the effects of UV-light exposure. 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid is a white to yellowish powder and is available under the brand name Sungard by Bayer.
Uses
Used in Sunscreen Formulations:
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid is used as a UV absorber for [application reason] providing protection against harmful UVA rays. It is an FDA approved sunscreen chemical with UVA-absorbing properties and an approved usage level of 5 to 10 percent.
Used in Cosmetics and Shampoos:
In the cosmetics industry, 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid is used as an ingredient to protect the products and the user's skin from the damaging effects of UV light exposure.
Used in the Textile Industry:
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid is used as a UV absorber for [application type] leather and textile fibers to enhance their durability and protect them from the degrading effects of sunlight.
Used in the Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, due to its UV-absorbing properties, 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid could potentially be used in the development of pharmaceuticals related to skin protection or treatments involving light exposure.
Originator
Uval,Dome,US,1965
Manufacturing Process
663 g of dichloroethane and 74.6 g 2-hydroxy-4-methoxybenzophenone were charged into a 3-neck flask equipped with stirrer, thermometer, reflux
condenser and dropping funnel and a heating mantle. The solution was heated
to the reflux temperature (85°C to 86°C) and was dehydrated by distilling off
66.5 g 1,2-dichloroethane. While maintaining at reflux, 30 g chlorosulfonic
acid was added slowly over a period of about two hours. The rate of addition
was regulated by the speed of evolution of the HCl. After all the chlorosulfonic
acid was added, the charge was still maintained at reflux for an additional 15
minutes to remove traces of HCl. It was then cooled to 5°C and filtered. The
filter cake was washed with 500 g cold 1,2-dichloroethane and dried. 98 g of
product were obtained.
Flammability and Explosibility
Nonflammable
Contact allergens
BZP-4 is widely used in cosmetics, particularly shampoos
and hair products. Cross-reactivity is rarely
expected in patients photoallergic to ketoprofen.
Check Digit Verification of cas no
The CAS Registry Mumber 4065-45-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,0,6 and 5 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 4065-45:
(6*4)+(5*0)+(4*6)+(3*5)+(2*4)+(1*5)=76
76 % 10 = 6
So 4065-45-6 is a valid CAS Registry Number.
InChI:InChI=1/C14H12O6S/c1-20-12-8-11(15)10(7-13(12)21(17,18)19)14(16)9-5-3-2-4-6-9/h2-8,15H,1H3,(H,17,18,19)/p-1
4065-45-6Relevant articles and documents
Preparation method of sun-screening agent 2-hydroxy-4-methoxy-5-sulfo benzophenone
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Paragraph 0052; 0054-0055, (2021/02/06)
The invention provides a preparation method of a sun-screening agent 2-hydroxy-4-methoxy-5-sulfo benzophenone. According to the method, SO3 is used as a sulfonating agent, the process conditions are mild, the reaction process is easy to control, the product selectivity is good, byproducts are few, and the purification process is simple and feasible. Compared with a traditional process, the production of waste acid is greatly reduced, the water content in the product is greatly reduced, acidic impurities are reduced to a great extent, the product quality is further improved, and the method is agreen and environment-friendly process and is beneficial to industrial production.
Synthesis process for 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid
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Paragraph 0011, (2016/11/28)
The invention discloses a synthesis process for 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid. The process comprises the treatment flow: adding 2-hydroxy-4-methoxybenzophenone and a solvent into an enamel reaction kettle, dripping chlorosulfonic acid under the protection of nitrogen with stirring, controlling the temperature of the materials in the kettle to be 20-25 DEG C through jacket water bath cooling and control of the dripping speed of the chlorosulfonic acid, and performing a reaction for 20-25 h; performing centrifugal filtering separation on a product after reaction is finished, washing the product by using a corresponding solvent, and drying the product under the protection of the nitrogen; recycling a hydrogen chloride (HCl) byproduct in an HCl recycling packing tower in a water circulation mode to form a 20%-30% hydrochloric acid aqueous solution, and neutralizing a little hydrogen chloride gas of tail gas by using a solid alkali packing tower; and performing distillation recycling of the solvent by using an atmospheric distillation tower of a solvent distillation recycling system, and recycling 2-hydroxy-4-methoxybenzophenone and 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid from raffinate at the bottom of the kettle.
A composition for lightening skin and hair
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, (2014/10/28)
Suggested is a composition comprising (a) sclareolide and (b1) at least one tyrosinase inhibitor; and/or (b2) at least one sun protection factor; and/or (b3) at least one anti-oxidants; and/or (b4) at least one anti-inflammatory agent; and/or (b5) at least one desquamating agent.