40547-32-8

Basic information

• Product Name: 1,3-Dihydroxy-6-methyl-9H-xanthen-9-one
• Synonyms: 1,3-Dihydroxy-6-methyl-9H-xanthen-9-one
• CAS NO: 40547-32-8
• Molecular Formula: C₁₄H₁₀O₄
• Molecular Weight: 242.2268
• Mol File: 40547-32-8.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,3-Dihydroxy-6-methyl-9H-xanthen-9-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dihydroxy-6-methyl-9H-xanthen-9-one(40547-32-8)
• EPA Substance Registry System: 1,3-Dihydroxy-6-methyl-9H-xanthen-9-one(40547-32-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 40547-32-8(Hazardous Substances Data)

Usage

Chemical structure

1,3-Dihydroxy-6-methyl-9H-xanthen-9-one

Type of compound

Synthetic organic compound

Classification

Xanthene dye

Fluorescence

Bright yellow-green color when excited by light

Applications

a. Fluorescent tracer in biological and medical imaging
b. Chemical and environmental analysis
c. Production of colorants and inks
d. pH indicator

Toxicity

Low-toxicity compound when used in regulated amounts

Potential hazards

Excessive exposure can cause irritation to eyes, skin, and respiratory system

Upstream product

• 108-73-6 3,5-dihydroxyphenol 
• 50-85-1 2-hydroxy-p-toluic acid 
• 108-46-3 recorcinol 

Downstream Products

• 959316-03-1 acetic acid 3-acetoxy-6-[(4-fluoro-phenyl)-hydrazonomethyl]-9-oxo-9H-xanthen-1-yl ester 

Relevant articles and documents

Synthesis and antiproliferative activity of aryl- and heteroaryl-hydrazones derived from xanthone carbaldehydes

In order to explore the antiproliferative effect associated with the xanthone framework, several arylhydrazonomethyl derivatives were synthesized from various isomeric 1,3-dihydroxyxanthone carbaldehydes. Variation in the position of the aldehydic functio

Incorporation of nitric oxide donor into 1,3-dioxyxanthones leads to synergistic anticancer activity

Fifty 1,3-dioxyxanthone nitrates (4a ～ i-n, n = 1–6) were designed and synthesized based on molecular similarity strategy. Incorporation of nitrate into 1,3-dioxyxanthones with electron-donating groups at 6–8 position brought about synergistic anticancer effect. Among them, compound 4g-4 was confirmed the most active agent against HepG-2 cells growth with an IC50 of 0.33 ± 0.06 μM. It dose-dependently increased intramolecular NO levels. This activity was attenuated by either NO scavenger PTIO or mitochondrial aldehyde dehydrogenase (mtADH) inhibitor PCDA. Apoptosis analysis indicated different contributions of early/late apoptosis and necrosis to cell death for different dose of 4g-4. 4g-4 arrested more cells on S phase. Results from Western Blot implied that 4g-4 regulated p53/MDM2 to promote cancer cell apoptosis. All the evidences support that 4g-4 is a promising anti-cancer agent.

Xanthones compounds and its antidepressant

The invention discloses xanthone compounds and their use in depression resistance. The xanthone compounds are compounds shown in the structural formula (I) or their pharmaceutically acceptable salts. An experiment proves that the xanthone compounds have good depression-resistant activity and a part of the xanthone compounds have depression-resistant activity superior to that of venlafaxine. Therefore, the xanthone compounds and their pharmaceutically acceptable salts can be used for preparation of depression-resistant drugs.