404-27-3

Basic information

• Product Name: 2,2,2-Trifluoro-4'-nitroacetanilide
• Synonyms: 2,2,2-Trifluoro-4'-nitroacetanilide;2,2,2-Trifluoro-N-(4-nitrophenyl)acetaMide
• CAS NO: 404-27-3
• Molecular Formula: C₈H₅F₃N₂O₃
• Molecular Weight: 234.13
• Product Categories: Amines;Aromatics
• Mol File: 404-27-3.mol
• Article Data: 27

Chemical Properties

• Melting Point: 149-150°C
• Appearance: /
• CAS DataBase Reference: 2,2,2-Trifluoro-4'-nitroacetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-Trifluoro-4'-nitroacetanilide(404-27-3)
• EPA Substance Registry System: 2,2,2-Trifluoro-4'-nitroacetanilide(404-27-3)

Safety Data

• Hazardous Substances Data: 404-27-3(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

N-(p-Nitrophenyl)-2,2,2-trifluoroacetamide (cas# 404-27-3) is a compound useful in organic synthesis.

Upstream product

• 404-24-0 2,2,2-trifluoro-N-phenylacetamide 
• 636-98-6 p-nitrobenzene iodide 
• 354-38-1 2,2,2-trifluoroacetamide 
• 100-01-6 4-nitro-aniline 
• 76-05-1 trifluoroacetic acid 
• 1492828-74-6 methyl 2,2,2-trifluoro-N-(p-nitrophenyl)acetimidate 
• 145372-31-2 N-(4-nitrophenyl)-2,2,2-trifluoroacetimidoyl chloride 
• 1228956-92-0 C₁₄H₁₄N₄O₂ 
• 407-25-0 trifluoroacetic anhydride 
• 62-53-3 aniline 
• 27691-52-7 S,S-dimethyl-N-(p-nitrophenyl)sulfilimine 
• 2923-18-4 sodium 2,2,2-trifluoroacetate 
• 100-28-7 4-Nitrophenyl isocyanate 
• 51599-76-9 N-trifluoroacetoxy succinimide 

Downstream Products

• 53446-90-5 N-(4-Amino-phenyl)-2,2,2-trifluoro-acetamide 
• 62-53-3 aniline 
• 76-05-1 trifluoroacetic acid 
• 1830-44-0 (2-amino-5-nitro-phenyl)-pyridin-2-yl-methanone 
• 75-89-8 2,2,2-trifluoroethanol 
• 100-01-6 4-nitro-aniline 
• 79692-35-6 Hexadecanoic acid (4-diethylamino-1-methyl-butyl)-[4-(3-{4-[(4-diethylamino-1-methyl-butyl)-hexadecanoyl-amino]-phenyl}-ureido)-phenyl]-amide 
• 344747-21-3 Hexadecanoic acid (4-diethylamino-1-methyl-butyl)-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-amide 
• 79692-45-8 Hexadecanoic acid (4-amino-phenyl)-(4-diethylamino-1-methyl-butyl)-amide 
• 79692-50-5 N-[4-(4-Diethylamino-1-methyl-butylamino)-phenyl]-2,2,2-trifluoro-acetamide 
• 100-15-2 N-methyl(p-nitroaniline) 
• 100-23-2 N,N-Dimethyl-4-nitroaniline 

Relevant articles and documents

The reaction of 4-substituted aryl isocyanates with NaBH4/trifluoroacetic acid (TFA)

Treatment of 4-substituted aryl isocyanates (cf. 2a-f) with NaBH4/TFA leads to the corresponding 4-substituted N,N-bis(2,2,2-trifluoroethyl)aniline derivatives (3a-d) in excellent yield except where an electron-withdrawing group is present (cf.

Carbon-Carbon Bond Formation of Trifluoroacetyl Amides with Grignard Reagents via C(O)-CF3 Bond Cleavage

The reaction of trifluoroacetyl amides with Grignard reagent for the substitution of CF3 group with various alkyl or aryl groups is described. A variety of aryl, quinolin-8-yl, and (hetero)alkyl functional groups as well as F, Cl, and Br atoms are well tolerated. These moisture-stable and easily available trifluoroacetyl amides can be conveniently obtained and used as new versatile precursors for isocyanates. The control experiments show that the reaction proceeds via an isocyanate intermediate and/or alkoxide/amide dual anionic intermediate.

Regioselective ortho-nitration of N-phenyl carboxamides and primary anilines using bismuth nitrate/acetic anhydride

An efficient and one-pot synthetic method for the regioselective ortho-nitration of the N-phenyl carboxamides and primary anilines has been developed by using bismuth nitrate and acetic anhydride as the nitrating reagents. Reaction proceeds at room temperature and results in corresponding ortho-nitrated products in moderate to excellent yields. This method provides an operationally simple, regioselective, and efficient access to synthesize o-nitro anilines under the mild conditions.