404-01-3

Basic information

• Product Name: 3',5'-DIFLUOROACETANILIDE
• Synonyms: BUTTPARK 76\07-27;3',5'-DIFLUOROACETANILIDE;3,5-DIFLUOROACETANILIDE;3,5-DIFLUOROACETANILIDE, 98% MIN.;1-Acetamido-3,5-difluorobenzene;N-(3,5-Difluorophenyl)acetamide
• CAS NO: 404-01-3
• Molecular Formula: C₈H₇F₂NO
• Molecular Weight: 171.14
• Mol File: 404-01-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 274.2°C at 760 mmHg
• Flash Point: 119.6°C
• Appearance: /
• Density: 1.307g/cm³
• Vapor Pressure: 0.00548mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 3',5'-DIFLUOROACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-DIFLUOROACETANILIDE(404-01-3)
• EPA Substance Registry System: 3',5'-DIFLUOROACETANILIDE(404-01-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 404-01-3(Hazardous Substances Data)

Usage

General Description

3',5'-Difluoroacetanilide is a chemical compound that belongs to the class of acetanilides, which are organic compounds derived from aniline. This specific compound is characterized by the presence of two fluorine atoms on the 3' and 5' positions of the acetanilide molecule. It is commonly used in pharmaceutical and chemical synthesis processes due to its reactivity and versatility as a building block for the creation of other compounds. Its chemical structure makes it suitable for various applications in medicinal chemistry and material science. Additionally, it has potential as an intermediate in the production of agricultural chemicals and dyes. However, like all chemicals, 3',5'-Difluoroacetanilide should be handled and used with proper safety measures in place to prevent any harmful effects on human health or the environment.

InChI:InChI=1/C8H7F2NO/c1-5(12)11-8-3-6(9)2-7(10)4-8/h2-4H,1H3,(H,11,12)

Upstream product

• 372-39-4 3,5-difluoroaniline 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 541539-64-4 N-(4-bromo-3,5-difluorophenyl)acetamide 
• 1421358-50-0 C₁₂H₁₃F₂NO 
• 361-71-7 3,5-difluoro-2-nitroacetanilide 
• 1446481-94-2 di-μ-tosyloxybis(4,6-difluoro-2-acetaminophenyl-2C,O)dipalladium(II) 
• 1259283-88-9 C₁₇H₁₃F₂NO 
• 2369-30-4 3,6-difluorobenzene-1,2-diamine 
• 698-52-2 1,4-diamino-2,5-difluorobenzene 
• 439-15-6 5,8-difluoro-2,3-diphenyl-quinoxaline 
• 400-05-5 1,4-dichloro-2,5-difluoro-benzene 
• 1542-36-5 2,5-difluoro-4-nitroaniline 
• 361-08-0 3,6-difluoro-2-nitroaniline 
• 361-72-8 2-amino-4,6-difluoronitrobenzene 

Relevant articles and documents

Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-b]indole Derivatives against Gram-Negative Multidrug-Resistant Pathogens

Due to the poor permeability across Gram-negative bacterial membranes and the troublesome bacterial efflux mechanism, only a few GyrB/ParE inhibitors with potent activity against Gram-negative pathogens have been reported. Among them, pyrimido[4,5-b]indol

Direct Photocatalytic Synthesis of Medium-Sized Lactams by C?C Bond Cleavage

Reported is a novel two-step ring-expansion strategy for expeditious synthesis of all ring sizes of synthetically challenging (hetero)aryl-fused medium-sized lactams from readily available 5–8-membered cyclic ketones. This step-economic approach features a remote radical (hetero)aryl migration from C to N under visible-light conditions. Broad substrate scope, good functional-group tolerance, high efficiency, and mild reaction conditions make this procedure very attractive. In addition, this method also provides expedient access to 13–15-membered macrolactams upon an additional one-step manipulation. Mechanistic studies indicate that the reaction involves an amidyl radical and is promoted by acid.

Revisiting the Synthesis of 4,6-Difluorobenzofuroxan: A Study of Its Reactivity and Access to Fluorinated Quinoxaline Oxides

New quinoxaline 1,4-dioxide derivatives have been synthesized from novel fluorinated benzofuroxans such as 4-fluorobenzofuroxan, which is prepared for the first time. Furthermore, the preparation 4,6-difluorobenzofuroxan has been revisited because we were