40019-44-1

Basic information

• Product Name: Biphenyl-4-amidoxime
• Synonyms: Biphenyl-4-amidoxime;N-Hydroxy-[1,1'-biphenyl]-4-carboxiMidaMide
• CAS NO: 40019-44-1
• Molecular Formula: C₁₃H₁₂N₂O
• Molecular Weight: 255.27192
• Mol File: 40019-44-1.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Biphenyl-4-amidoxime(CAS DataBase Reference)
• NIST Chemistry Reference: Biphenyl-4-amidoxime(40019-44-1)
• EPA Substance Registry System: Biphenyl-4-amidoxime(40019-44-1)

Safety Data

• Hazardous Substances Data: 40019-44-1(Hazardous Substances Data)

Usage

Description

Biphenyl-4-amidoxime is a synthetic intermediate useful for pharmaceutical synthesis.

Upstream product

• 2920-38-9 4-cyano-1,1'-biphenyl 
• 40143-27-9 biphenyl-4-carbaldehyde oxime 
• 3218-36-8 4-Phenylbenzaldehyde 

Downstream Products

• 125772-44-3 biphenyl-4-carboxamidine 
• 92427-80-0 3-biphenyl-4-yl-5-chloromethyl-[1,2,4]oxadiazole 
• 40019-23-6 3-(biphenyl-4-yl)-1,2,4-oxadiazole-5-carboxylic acid ethyl ester 
• 1040725-88-9 3-(4-biphenyl)-1,2,4-oxadiazolyl methyl-3'-(4-methoxyphenyl)-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)dione 
• 422564-84-9 3-(biphenyl-4-yl)-5-(1H-indol-3-yl)-1,2,4-oxadiazole 

Relevant articles and documents

Cobalt-Catalyzed, Directed Intermolecular C-H Bond Functionalization for Multiheteroatom Heterocycle Synthesis: The Case of Benzotriazine

Transition-metal-catalyzed, directed intermolecular C-H bond functionalization is synthetically useful but heavily underexplored in multiheteroatom heterocycle synthesis. Herein we report a cobalt catalytic method for the formation of a three-nitrogen-bearing benzotriazine scaffold via the coupling of arylhydrazine and oxadiazolone. This synthetic protocol features a low-cost base metal catalyst, a maximum number of heteroatoms built into a heterocycle, a distinct synthetic logic for benzotriazines, a superior step economy, and a broad substrate scope.

SO2F2-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN)

A simple, mild and practical cascade process for the direct conversion of aldehydes to cyanamides was developed featuring a wide substrate scope and great functional group tolerability. This method allows for transformations of readily available, inexpensive, and abundant aldehydes to highly valuable cyanamides in a pot, atom, and step-economical manner with a green nitrogen source. This protocol will serve as a robust tool for the installation of the cyanamide moiety in various complicated molecules.

Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists

Recent findings have shown that Farnesoid X Receptor (FXR) antagonists might be useful in the treatment of cholestasis and related metabolic disorders. In this paper, we report the discovery of a new chemotype of FXR antagonists featured by a 3,5-disubsti