40017-76-3 Usage
Description
3-(2',6'-DIFLUOROPHENYL)-3-OXOPROPANENITRILE, also known as 2,6-difluorobenzoylacetonitrile, is an organic compound with the molecular formula C9H4F2NO. It is characterized by the presence of a nitrile group (C≡N) and a 2',6'-difluorophenyl group, which contributes to its unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
3-(2',6'-DIFLUOROPHENYL)-3-OXOPROPANENITRILE is used as an intermediate compound for the synthesis of thienodiazepinones. These synthesized compounds can exhibit poor central nervous system depressant activity, making them potentially useful in the development of new medications targeting the central nervous system.
Check Digit Verification of cas no
The CAS Registry Mumber 40017-76-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,0,1 and 7 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 40017-76:
(7*4)+(6*0)+(5*0)+(4*1)+(3*7)+(2*7)+(1*6)=73
73 % 10 = 3
So 40017-76-3 is a valid CAS Registry Number.
40017-76-3Relevant articles and documents
Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity
Marcyk, Paul T.,Leblanc, Emmanuelle V.,Kuntz, Douglas A.,Xue, Alice,Ortiz, Francisco,Trilles, Richard,Bengtson, Stephen,Kenney, Tristan M. G.,Huang, David S.,Robbins, Nicole,Williams, Noelle S.,Krysan, Damian J.,Privé, Gilbert G.,Whitesell, Luke,Cowen, Leah E.,Brown, Lauren E.
, p. 1139 - 1169 (2021/02/01)
The essential eukaryotic chaperone Hsp90 regulates the form and function of diverse client proteins, many of which govern thermotolerance, virulence, and drug resistance in fungal species. However, use of Hsp90 inhibitors as antifungal therapeutics has be