394-01-4

Basic information

• Product Name: 4-Fluoro-2-nitrobenzoic acid
• Synonyms: BUTTPARK 45\01-65;4-FLUORO-2-NITROBENZOIC ACID;2-NITRO-4-FLUOROBENZOIC ACID;RARECHEM AL BO 1973;4-Fluoro-2-Nitrobenzoic Acid 2-Nitro-4-Fluorobenzoic Acid;2 4-Fluoro-2-Nitrobenzoic Acid;4-FLUORO-2-NITROBENZOIC ACID 98%;4-Fluoro-2-nitrobenzotc acid
• CAS NO: 394-01-4
• Molecular Formula: C₇H₄FNO₄
• Molecular Weight: 185.11
• EINECS: 206-890-9
• Product Categories: FINE Chemical & INTERMEDIATES;blocks;Carboxes;FluoroCompounds;NitroCompounds;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzene series;Benzoic acid;C7;Carbonyl Compounds;Carboxylic Acids;Aryl Fluorinated Building Blocks;Building Blocks;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks
• Mol File: 394-01-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 147-148°C
• Boiling Point: 343.8 °C at 760 mmHg
• Flash Point: 161.7 °C
• Appearance: white to light yellow crystal powder
• Density: 1.568 g/cm³
• Vapor Pressure: 2.63E-05mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 2.14±0.25(Predicted)
• CAS DataBase Reference: 4-Fluoro-2-nitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-2-nitrobenzoic acid(394-01-4)
• EPA Substance Registry System: 4-Fluoro-2-nitrobenzoic acid(394-01-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 394-01-4(Hazardous Substances Data)

Usage

Description

4-Fluoro-2-nitrobenzoic acid is an organic compound characterized by the presence of a fluorine atom at the 4-position and a nitro group at the 2-position on a benzene ring, with a carboxylic acid functional group. It is a versatile chemical intermediate with potential applications in various fields.

Uses

Used in Chemical Research:
4-Fluoro-2-nitrobenzoic acid is used as a chemical intermediate for studying the reactions of substituted pyridines with the salicyl phosphate dianion. This application is valuable for understanding the reactivity and properties of pyridine derivatives and their interactions with other chemical species.

Biochem/physiol Actions

4-Fluoro-2-nitrobenzoic acid enhances the binding of insulin to adipocytes.

InChI:InChI=1/C7H4FNO4/c8-4-1-2-5(7(10)11)6(3-4)9(12)13/h1-3H,(H,10,11)

Upstream product

• 446-10-6 2-nitro-4-fluorotoluene 
• 80517-21-1 4-fluoro-2-nitrobenzonitrile 
• 106754-80-7 4-fluoro-2-nitrobenzamide 
• 2923-96-8 4-fluoro-2-nitrobenzaldehyde 
• 390-06-7 4-fluoro-2-nitro-1,1′-biphenyl 
• 64-19-7 acetic acid 
• 364-78-3 2-nitro-4-fluoroaniline 
• 448-39-5 N-(4-fluoro-2-nitrophenyl)acetamide 
• 119-32-4 4-Methyl-3-nitroanilin 
• 731-86-2 4-Fluor-2-nitro-1-diacetoxymethyl-benzol 
• 459-56-3 4-fluorobenzylic alcohol 
• 1043416-40-5 (4-fluoro-2-nitrophenyl)methanol 

Downstream Products

• 62513-46-6 α-acetyl-α-(4-fluoro-2-nitrobenzoyl)-γ-butyrolactone 
• 1644068-73-4 C₁₁H₈FNO₃ 
• 402-67-5 3-fluoro-1-nitrobenzene 
• 1214346-44-7 1-(4-fluoro-2-nitrophenyl)ethanone 
• 1080674-69-6 C₂₆H₂₂FNO₆S 
• 1080674-67-4 C₂₉H₂₇FN₂O₆S 
• 1081504-62-2 C₂₈H₂₆FN₃O₅S 
• 159305-15-4 1-(2-Amino-4-fluorophenyl)ethanone 
• 1080674-92-5 C₂₃H₂₃FN₂O₅S 
• 1080674-91-4 C₂₃H₂₃FN₂O₅S 
• 1080674-80-1 C₂₂H₂₁FN₂O₄ 

Relevant articles and documents

Preparation method of 2-amino-4-fluorobenzoic acid

The invention relates to a preparation method of 2-amino-4-fluorobenzoic acid, which comprises the following steps: by taking cheap and easily available 4-fluorobenzyl alcohol as a raw material, firstly carrying out nitration reaction to obtain a nitro substitute, then carrying out oxidation reaction on the nitro substitute to obtain benzoic acid oxide, and finally carrying out reduction reaction on the benzoic acid oxide to finally obtain 2-amino-4-fluorobenzoic acid which is high in purity and high in yield. The preparation method disclosed by the invention has the characteristics of cheap and easily available raw materials, short reaction route, conventional reaction, mild reaction conditions, high yield and easiness in industrial production.

Condensed pyrazole derivatives, process for producing the same and use thereof

Novel pharmaceutical compositions for inhibiting Th2-selective immune response and pharmaceutical compositions for inhibiting cyclooxygenase comprising condensed pyrazole derivatives represented by the general formula (I): or salts thereof.

FLUORINATED TRICYCLIC NEUROLEPTICS WITH PROLONGED ACTION: 7-FLUORO-11--2-ISOPROPYL-10,11-DIHYDRODIBENZOTHIEPIN

Substitution reaction of 11-chloro-7-fluoro-2-isopropyl-10,11-dihydrodibenzothiepin with 1-(2-hydroxyethyl)piperazine gave the title compound I which proved a very potent and long acting oral neuroleptic agent ("isofloxythepin").Its resolution by means of dibenzoyl-(+)- and (-)-tartaric acid led to (-)- and (+)-enantiomer out of which the former represents the neuroleptically active component.In the synthetic sequence leading to I, preparation of two key intermediates was re-elaborated using new partial sequences: 4-fluoro-2-iodobenzoic acid (XIII) from 4-fluoro-2-nitroaniline (V) via the nitrile VI and the acids VIII and XII, and acetic acid (XVIII) from XIII via XIV and the compounds XV-XVII.The sulfoxides and N-oxides XIX-XXII were prepared as potential metabolites of isofloxithepin (I).