387827-69-2

Basic information

• Product Name: 2-(4-FLUOROPHENYL)-6-METHYLPYRIDINE
• Synonyms: 2-(4-FLUOROPHENYL)-6-METHYLPYRIDINE
• CAS NO: 387827-69-2
• Molecular Formula: C₁₂H₁₀FN
• Molecular Weight: 187.2129032
• Mol File: 387827-69-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 266.791 °C at 760 mmHg
• Flash Point: 115.152 °C
• Appearance: /
• Density: 1.112 g/cm³
• Vapor Pressure: 0.014mmHg at 25°C
• Refractive Index: 1.551
• CAS DataBase Reference: 2-(4-FLUOROPHENYL)-6-METHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUOROPHENYL)-6-METHYLPYRIDINE(387827-69-2)
• EPA Substance Registry System: 2-(4-FLUOROPHENYL)-6-METHYLPYRIDINE(387827-69-2)

Safety Data

• Hazardous Substances Data: 387827-69-2(Hazardous Substances Data)

Usage

Molecular structure

A pyridine derivative with a 4-fluorophenyl group and a methyl group attached to the 2nd and 6th carbon atoms, respectively.

Usage

Commonly used as an intermediate in the synthesis of pharmaceutical compounds and agrochemicals.

Application

Can be used as a building block in organic synthesis for the production of various compounds.

Relevance in organic chemistry

The chemical structure of 2-(4-Fluorophenyl)-6-methylpyridine makes it useful for its specific reactivity and properties, making it a valuable tool in the field of organic chemistry.

InChI:InChI=1/C12H10FN/c1-9-3-2-4-12(14-9)10-5-7-11(13)8-6-10/h2-8H,1H3

Upstream product

• 18368-57-5 2-mercapto-6-methylpyridine 
• 281221-71-4 6-methylpyridine-2-sulfonyl chloride 
• 1765-93-1 4-fluoroboronic acid 
• 5315-25-3 2-bromo-6-methylpyridine 
• 10412-98-3 5-oxohexanenitrile 

Relevant articles and documents

Desulfonative Suzuki–Miyaura Coupling of Sulfonyl Fluorides

Sulfonyl fluorides have emerged as powerful “click” electrophiles to access sulfonylated derivatives. Yet, they are relatively inert towards C?C bond forming transformations, notably under transition-metal catalysis. Here, we describe conditions under which aryl sulfonyl fluorides act as electrophiles for the Pd-catalyzed Suzuki–Miyaura cross-coupling. This desulfonative cross-coupling occurs selectively in the absence of base and, unusually, even in the presence of strong acids. Divergent one-step syntheses of two analogues of bioactive compounds showcase the expanded reactivity of sulfonyl fluorides to encompass both S?Nu and C?C bond formation. Mechanistic experiments and DFT calculations suggest oxidative addition occurs at the C?S bond followed by desulfonation to form a Pd-F intermediate that facilitates transmetalation.

ORGANIC METAL COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE including same

Organic metal compounds, and organic light-emitting devices including the same are provided. The organic metal compound has a chemical structure of Formula (I):The definitions of R1-R18 and n are as defined in specification.

Organometallic COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE

The invention provides an organometallic compound and an organic light-emitting device including the same. The organometallic compound has a structure represented by formula (I), wherein at least oneof R3, R4, R5, R6, R7, R8, R9, R10 and R11 is -Si (R19)