38749-76-7

Basic information

• Product Name: Pyridine, 3-bromo-4-ethyl- (9CI)
• Synonyms: Pyridine, 3-bromo-4-ethyl- (9CI);3-Bromo-4-ethyl-pyridine ;4-Ethyl-3-bromopyridine
• CAS NO: 38749-76-7
• Molecular Formula: C₇H₈BrN
• Molecular Weight: 186.04912
• Product Categories: PYRIDINE
• Mol File: 38749-76-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 216.7 °C at 760 mmHg
• Flash Point: 84.8 °C
• Appearance: /
• Density: 1.413 g/cm³
• Vapor Pressure: 0.203mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.68±0.18(Predicted)
• CAS DataBase Reference: Pyridine, 3-bromo-4-ethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 3-bromo-4-ethyl- (9CI)(38749-76-7)
• EPA Substance Registry System: Pyridine, 3-bromo-4-ethyl- (9CI)(38749-76-7)

Safety Data

• Hazardous Substances Data: 38749-76-7(Hazardous Substances Data)

Usage

Description

Pyridine, 3-bromo-4-ethyl(9CI), also known as 3-bromo-4-ethylpyridine, is an organic compound with the chemical formula C7H8BrN. It is a derivative of pyridine, a heterocyclic aromatic compound, with a bromine atom at the third position and an ethyl group attached to the fourth carbon atom. Pyridine, 3-bromo-4-ethyl(9CI) belongs to the class of pyridine derivatives, which are extensively utilized in the pharmaceutical and agrochemical industries. Due to its unique structure and properties, 3-bromo-4-ethyl-pyridine serves as a valuable building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. However, it is essential to handle this chemical with care, as it is flammable and can cause irritation to the skin, eyes, and respiratory system if not managed properly.

Uses

Used in Pharmaceutical Industry:
Pyridine, 3-bromo-4-ethyl(9CI) is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with improved therapeutic properties. Pyridine, 3-bromo-4-ethyl(9CI)'s reactivity and functional groups make it suitable for further chemical modifications, enabling the creation of novel drug candidates with enhanced efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical sector, Pyridine, 3-bromo-4-ethyl(9CI) is employed as a building block for the synthesis of various agrochemicals, such as pesticides and herbicides. Its chemical properties enable the development of new compounds with improved activity against pests and weeds, contributing to more effective and sustainable agricultural practices.
Used in Organic Synthesis:
Pyridine, 3-bromo-4-ethyl(9CI) is utilized as a versatile starting material in organic synthesis. Its reactivity and functional groups make it an attractive candidate for the preparation of various organic compounds, including dyes, polymers, and other specialty chemicals. Pyridine, 3-bromo-4-ethyl(9CI)'s ability to undergo a range of chemical reactions, such as nucleophilic substitution, electrophilic substitution, and cross-coupling reactions, allows for the synthesis of a wide array of products with diverse applications.
Used in Research and Development:
Pyridine, 3-bromo-4-ethyl(9CI) is also employed in research and development settings, where it serves as a valuable tool for studying the properties and reactivity of pyridine derivatives. Its unique structure and functional groups provide insights into the behavior of similar compounds, aiding in the discovery of new synthetic routes and the development of novel applications in various industries.

InChI:InChI=1/C7H8BrN/c1-2-6-3-4-9-5-7(6)8/h3-5H,2H2,1H3

Upstream product

• 536-75-4 4-Ethylpyridine 
• 626-55-1 3-Bromopyridine 

Downstream Products

• 2096330-85-5 4-ethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 

Relevant articles and documents

6-AMINOPYRIDIN-3-YL PYRAZOLES AS MODULATORS OF RORgT

The present invention comprises compounds of Formula I. wherein: R1, Q, R3, R4, R5, R6, A1, and A2 are defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-γ-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

SYNTHESIS OF 3-HALO- AND 3-FORMYL-4-ALKYLPYRIDINES

In the presence of a catalytic amount of cuprous iodide, the addition of Grignard reagents to the 1-phenoxycarbonyl salts of 3-halopyridines gives 4-alkyl-3-halo-1-phenoxycarbonyl-1,4-dihydropyridines.The crude dihydropyridines were aromatized with o-chloroanil to give 4-alkyl-3-halopyridines.Several 4-alkylnicotinaldehydes were synthesized in a similar manner from the cyclic acetal (1,3-dioxolane) of 3-pyridinecarboxaldehyde.After aromatization with sulfur, the crude acetals were hydrolyzed with oxalic acid to give the desired pyridinecarboxaldehydes.