3848-36-0

Basic information

• Product Name: 4-CHLOROBENZALDEHYDE OXIME
• Synonyms: AKOS B004078;4-CHLOROBENZALDEHYDE OXIME;4-CHLOROBENZALDOXIME;4-CHLOROBENZENECARBALDEHYDE OXIME;N-(4-Chlorobenzylidene)hydroxylamine;benzaldehyde, 4-chloro-, oxime
• CAS NO: 3848-36-0
• Molecular Formula: C₇H₆ClNO
• Molecular Weight: 155.58
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 3848-36-0.mol
• Article Data: 130

Chemical Properties

• Melting Point: 108-110°C
• Boiling Point: 233.2 °C at 760 mmHg
• Flash Point: 94.8 °C
• Appearance: /
• Density: 1.217 g/cm³
• Vapor Pressure: 0.0314mmHg at 25°C
• Refractive Index: 1.55
• PKA: 10.45±0.10(Predicted)
• CAS DataBase Reference: 4-CHLOROBENZALDEHYDE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLOROBENZALDEHYDE OXIME(3848-36-0)
• EPA Substance Registry System: 4-CHLOROBENZALDEHYDE OXIME(3848-36-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 3848-36-0(Hazardous Substances Data)

Usage

General Description

4-Chlorobenzaldehyde Oxime is a chemical compound that belongs to the class of organic compounds known as benzene and substituted derivatives, specifically an aromatic compound consisting of a benzene substituted by a chloro group and an oxime group. Well recognized by its systematic name 4-chlorobenzonitrile oxime, its chemical formula is C7H6ClNO, and it may appear as a white crystalline substance. This substance is used in the chemical industry, but due to its potential harmful effects, it is recommended that proper cautionary measures be considered in its handling and storage.

InChI:InChI=1/C7H6ClNO/c8-7-3-1-6(2-4-7)5-9-10/h1-5,10H

Upstream product

• 110-89-4 piperidine 
• 119991-09-2 4-Chloro-benzaldehyde O-(2,4-dinitro-phenyl)-oxime 
• 2403-54-5 2-(4-chlorophenyl)-1,3-dioxolane 
• 25370-09-6 dibenzylcarbamyl chloride 
• 89970-60-5 C₇H₆ClN₂O₂^(1-)*Na⁽¹⁺⁾ 
• 104-88-1 4-chlorobenzaldehyde 
• 91757-32-3 3-(4-Chloro-phenyl)-5-phenyl-4,5-dihydro-[1,2,4]oxadiazin-6-one 
• 108-91-8 cyclohexylamine 
• 30866-47-8 N-(2-iminochromen-3-carbonyl)-N'-(4-chlorobenzylidene)carbohydrazide 
• 75605-57-1 N'-(4-chlorobenzylidene)-2-hydroxyiminochromen-3-carbohydrazide 
• 74-89-5 methylamine 
• 104-86-9 4-chlorobenzylamine 
• 873-76-7 para-Chlorobenzyl alcohol 
• 5470-11-1 hydroxylamine hydrochloride 

Downstream Products

• 52540-33-7 p-Chlor-benzaldehydoxim-diethylorthoacetat 
• 34768-54-2 C₁₄H₁₇ClN₂O₂ 
• 71059-53-5 O--p-chlor-benzaldoxim 
• 52540-32-6 p-Chlor-benzaldehydoxim-diethylorthoformiat 
• 13181-85-6 4-Chloro-benzaldehyde O-(2,4-dinitro-phenyl)-oxime 
• 19957-27-8 O-(1-Naphthylcarbamoyl)-p-chlorbenzaldoxim 
• 13180-80-8 4-[1-(4-Chloro-phenyl)-meth-(E)-ylideneaminooxy]-3-nitro-benzoic acid methyl ester 
• 34755-71-0 C₂₀H₃₁ClN₂O₂ 
• 13180-86-4 2-[1-(4-Chloro-phenyl)-meth-(Z)-ylideneaminooxy]-3,5-dinitro-benzoic acid methyl ester 
• 54222-79-6 C₁₆H₁₆Cl₂N₂O₂Si 
• 1822-97-5 3-(4-chlorophenyl)-5-(trichloromethyl)-1,2,4-oxadiazole 
• 28123-63-9 4-chlorobenzohydroximoyl chloride 
• 51307-68-7 N-4-chlorobenzylhydroxylamine 
• 26218-72-4 3,4-bis-(4-chloro-phenyl)-furazan 2-oxide 

Relevant articles and documents

A catalytic regioselective procedure for the synthesis of aryl oximes in the presence of palladium nanoparticles

The synthesis of aryl oximes from aryl aldehyde derivatives was carried out using hydroxylamine hydrochloride and aluminum oxy hydroxide-supported palladium (Pd/AlO(OH) nanoparticles. The procedure is revealed via the regioselective synthesis of oxime der

Poly(N-vinylimidazole): A biocompatible and biodegradable functional polymer, metal-free, and highly recyclable heterogeneous catalyst for the mechanochemical synthesis of oximes

The catalytic activity of poly(N-vinylimidazole), a biocompatible and biodegradable synthetic functional polymer, was investigated for the synthesis of oximes as an efficient, halogen-free, and reusable heterogeneous catalyst. The corresponding oximes were afforded in high to excellent yields at room temperature and in short times using the planetary ball mill technique. Some merits, such as the short reaction times and good yields for poorly active carbonyl compounds, and avoiding toxic, expensive, metal-containing catalysts, and hazardous and flammable solvents, can be mentioned for the current catalytic synthesis of the oximes. Furthermore, the heterogeneous organocatalyst could be easily separated after the reaction, and the regenerated catalyst was reused several times with no significant loss of its catalytic activity.

Site selective synthesis and anti-inflammatory evaluation of Spiro-isoxazoline stitched adducts of arteannuin B

A library of new spiroisoxazoline analogues of arteannuin B was synthesized through 1, 3-dipolar cycloaddition in stereoselective fashion and consequently screened for anti-inflammatory activity in RAW 264.7 macrophage cells. Three potent analogues (8i, 8 m, and 8n) were found to attenuate the LPS induced release of cytokines IL-6 and TNF-α more potently than the parent molecule. Also, the inhibition of LPS induced nitric oxide production in these cells show moderate to high efficacy. None of the three potent molecules have altered the viability of RAW 264.7 cells following 48 h incubation suggesting that the inhibition of cytokines and nitric oxide production exhibited in the cells was not due to toxicity. In addition, these compounds exhibit an IC50 range of 0.17 μM-1.57 μM and 0.09 μM-0.35 μM for the inhibition of IL-6 release and nitric oxide production respectively. The results disclose potent inhibition of pro-inflammatory mediators which are encouraging and warrant further investigations to develop new therapeutic agents for inflammatory diseases.