38197-43-2Relevant articles and documents
Studies toward the Total Syntheses of Calyciphylline D-Type Daphniphyllum Alkaloids
Cui, Yi,Ren, Jun,Lv, Jiayuan,Wang, Zhongwen
supporting information, p. 9189 - 9193 (2021/11/30)
An efficient construction of an aza-[5.7.6.5] tetracyclic core structure of calyciphylline D-type Daphniphyllum alkaloids has been achieved. The synthetic route features a diastereoselective cyclopropanation, efficient construction of the core bridged 8-aza-[3.2.1]octane skeleton through a [3 + 2] IMCC strategy, oxidative dearomatization of phenol, and gram-scale preparation in each step.
ANTAGONISTS OF HUMAN INTEGRIN (ALPHA4)(BETA7)
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Paragraph 0228; 0775; 0776, (2019/10/29)
Disclosed are small molecule antagonists of α4β7 integrin, and methods of using them to treat a number of specific diseases or conditions.
1,2-asymmetric induction in diastereoselective zwitterionic aza-Claisen rearrangements: Key steps in optically active alkaloid synthesis
Heescher, Carolin,Schollmeyer, Dieter,Nubbemeyer, Udo
supporting information, p. 4399 - 4404 (2013/07/26)
The zwitterionic aza-Claisen rearrangement of optically active N-allylpyrrolidines and α-phenoxyacetyl fluorides proceeds with complete simple diastereoselectivity (internal asymmetric induction) and complete 1,2-asymmetric induction to generate a new C-C bond adjacent to a chiral C-N-Boc functionality. The resulting γ,δ-unsaturated amides were cyclised to give the corresponding pyrrolizidinones, which enabled the determination of the relative configuration of the stereotriads. Vinyl group degradation and a final lactam reduction gave an optically active analogue of (+)-petasinine (a pyrrolizidine alkaloid). Furthermore, the stereotriad-containing amides should be useful key intermediates for the total synthesis of optically active elaeocarpin (an indolizidine alkaloid). Copyright