38186-83-3

Basic information

• Product Name: 5-Amino-2-bromo-3-methylpyridine
• Synonyms: 5-AMINO-2-BROMO-3-METHYLPYRIDINE;5-AMINO-2-BROMO-3-PICOLINE;2-bromo-3-methyl-5-aminopyridine;2-BROMO-5-AMINO-3-PICOLINE;5-AMINO-2-BROMO-3-PYRIDINE;5-AMINO-2-BROMO-3-PICOLINE (5-AMINO-2-BROMO-3-METHYLPYRIDINE);6-bromo-5-methylpyridine-3-amine;6-bromo-5-methylpyridin-3-amine
• CAS NO: 38186-83-3
• Molecular Formula: C₆H₇BrN₂
• Molecular Weight: 187.04
• Product Categories: Pyridine;Pyridines;Boronic Acid
• Mol File: 38186-83-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 97-100℃
• Boiling Point: 304.978 °C at 760 mmHg
• Flash Point: 138.246 °C
• Appearance: Gray/Solid
• Density: 1.593 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.617
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.02±0.20(Predicted)
• CAS DataBase Reference: 5-Amino-2-bromo-3-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-2-bromo-3-methylpyridine(38186-83-3)
• EPA Substance Registry System: 5-Amino-2-bromo-3-methylpyridine(38186-83-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• RIDADR: UN2811
• HazardClass: 6.1
• Hazardous Substances Data: 38186-83-3(Hazardous Substances Data)

Usage

Description

5-Amino-2-bromo-3-methylpyridine is a heterocyclic compound characterized by the presence of a pyridine ring with a bromine atom at the 2nd position, a methyl group at the 3rd position, and an amino group at the 5th position. This organic compound is known for its potential applications in various industries, particularly as a pharmaceutical intermediate.

Uses

Used in Pharmaceutical Industry:
5-Amino-2-bromo-3-methylpyridine is used as a pharmaceutical intermediate for the synthesis of various drugs and medications. Its unique chemical structure allows it to serve as a building block in the development of new pharmaceutical compounds, contributing to the advancement of medical treatments.
As a pharmaceutical intermediate, 5-Amino-2-bromo-3-methylpyridine plays a crucial role in the synthesis of a wide range of therapeutic agents. Its ability to form various chemical bonds and interact with other molecules makes it a valuable component in the creation of new drugs with specific therapeutic properties. This versatility in chemical reactivity and structural diversity is what makes it an essential compound in the pharmaceutical industry.

Physical Form

5-Amino-2-bromo-3-methylpyridine is a crystal-powder at 20°C.

InChI:InChI=1/C6H7BrN2/c1-4-2-5(8)3-9-6(4)7/h2-3H,8H2,1H3

Upstream product

• 23132-21-0 2-bromo-3-methyl-5-nitropyridine 

Downstream Products

• 96206-67-6 N-(6-bromo-5-methylpyridin-3-yl)acetamide 
• 1194098-48-0 C₁₂H₁₇BrN₂O 
• 1344734-74-2 C₃₃H₃₆FN₇O₅S 
• 1344734-67-3 C₂₄H₃₀FN₅O₄ 
• 1344734-66-2 C₂₄H₂₈FN₅O₃ 
• 1344734-65-1 C₂₃H₂₈BrFN₄O₃ 

Relevant articles and documents

Discovery of novel pyridyl carboxamides as potent CCR5 antagonists and optimization of their pharmacokinetic profile in rats

A novel series of pyridyl carboxamide-based CCR5 inhibitors was designed, synthesized, and demonstrated to be highly potent against HIV-1 infection in both HOS and PBL assays. Attempts to evaluate this series of compounds in a rat PK model revealed its instability in rat plasma. A hypothesis for this liability was proposed, and strategies to overcome this issue were pursued, leading to discovery of highly potent 40 and 41, which featured dramatically improved rat PK profiles. 2011 Elsevier Ltd. All rights reserved.