381233-78-9

Basic information

• Product Name: 5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE
• Synonyms: [2,3'-BIPYRIDIN]-6'(1'H)-ONE;5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE;5-(Pyridin-2-yl)-2(1H)-pyridone;5-(Pyridin-2-yl)-1,2-dihydropyridin-2-one;5-(Pyridin-2-yl)pyridin-2(1H)-one;5-(2-Pyridyl)pyridin-2(1H)-one;5-pyridin-2-yl-1H-pyridin-2-one;5-(2-PYRIDYL)-2-PYRIDONE
• CAS NO: 381233-78-9
• Molecular Formula: C₁₀H₈N₂O
• Molecular Weight: 172.19
• Mol File: 381233-78-9.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 434.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.221±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 10.85±0.10(Predicted)
• CAS DataBase Reference: 5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE(381233-78-9)
• EPA Substance Registry System: 5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE(381233-78-9)

Safety Data

• Hazardous Substances Data: 381233-78-9(Hazardous Substances Data)

Usage

Description

5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique chemical structure, which includes a pyridine ring and a dihydropyridine ring, making it a versatile building block for the development of new drugs.

Uses

Used in Pharmaceutical Industry:
5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE is used as a key intermediate in the synthesis of AMPA receptor antagonists for the treatment of neurological diseases. These diseases are characterized by the dysfunction of glutamatergic neurotransmission, which can lead to a range of neurological disorders. By acting as an antagonist to the AMPA receptor, this compound can help regulate the excitatory neurotransmission and alleviate the symptoms associated with these conditions.

InChI:InChI=1S/C10H8N2O/c13-10-5-4-8(7-12-10)9-3-1-2-6-11-9/h1-7H,(H,12,13)

Upstream product

• 149281-42-5 6-chloro-N-methoxy-N-methylpyridine-3-carboxamide 
• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 
• 58757-38-3 6-Chloronicotinoyl chloride 
• 163105-89-3 2-methoxy-pyridine-5-boronic acid 
• 17997-47-6 2-tri-n-butylstannylpyridine 
• 13472-85-0 2-methoxy-5-bromopyridine 
• 624-28-2 2,5-dibromopyridine 
• 109-04-6 2-bromo-pyridine 
• 1054483-78-1 2-hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 342618-54-6 6'-bromo-[2,3']bipyridinyl 
• 1124-29-4 1-(6-hydroxypyridin-3-yl)ethanone 
• 21966-78-9 1,3-dimethyl-2-oxo-2,3-dihydropyrimidin-1-ium chloride 
• 93297-75-7 2-chloro-5-(2'-pyridyl)pyridine 
• 381725-49-1 2-methoxy-5-(pyridin-2-yl)pyridine 

Downstream Products

• 1338225-44-7 C₁₈H₁₆N₂S 
• 381248-06-2 3-bromo-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridine-2-one 
• 380917-97-5 [14C]-Perampanel 
• 381725-50-4 1-phenyl-5-(pyridin-2-yl)-2(1H)-pyridone 
• 543699-66-7 3-bromo-1-(3-methoxyphenyl)-5-(2-pyridyl)-1,2-dihydropyridin-2-one 
• 1415212-88-2 C₁₇H₁₃BrN₂O₂ 
• 1415212-91-7 C₁₇H₁₀BrN₃O 
• 380918-50-3 C₂₃H₁₈N₂O 
• 381233-79-0 3-bromo-5-(2-pyridyl)-1,2-dihydropyridin-2-one 
• 380919-26-6 3-(2-Trifluoromethylphenyl)-5-(2-pyridyl)-1-(3-pyridyl) 1,2-dihydropyridin-2-one 

Relevant articles and documents

pyrrole logical sequence handkerchief nai intermediate preparation method (by machine translation)

The invention relates to a simple operation, raw materials are easy, and the production cost is low, the quality of the product is good and is suitable for the industrial production of the intermediate pyrrole logical sequence handkerchief nai 5 - (pyridine - 2 - yl) - 2 (1H) - pyridone of the preparation method. (by machine translation)

Development of Novel PET Probes for Central 2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic Acid Receptors

We document the development of PET probes for central AMPA receptors and their application to in vivo animal imaging. An initial screening of perampanel derivatives was performed to identify probe candidates. Despite the high autoradiographic contrast yie

METHODS FOR PREPARING INTERMEDIATES OF PERAMPANEL

Methods for the synthesis of 2-alkoxy-5-(pyridin-2-yl)pyridine of formula I or salts thereof are provided.