3728-20-9

Basic information

• Product Name: H-D-TYR-OME HCL
• Synonyms: (R)-Methyl 2-aMino-3-(4-hydroxyphenyl)propanoate hydrochloride;H-D-Tyr-OMe hydrochloride;H-D-Tyr-OMe;D-Tyr-OMe·HCl;D-Tyrosine methyl ester hydrochloride≥ 98% (HPLC);D-TYROSINE ETHYL OME HCl;Methyl D-Tyrosinate Hydrochloride,99%e.e.;H-D-TYR-OME HCL
• CAS NO: 3728-20-9
• Molecular Formula: C₁₀H₁₄NO₃*Cl
• Molecular Weight: 231.68
• EINECS: 223-084-2
• Product Categories: Amino Acids and Derivatives;Amino hydrochloride;Amino Acid Derivatives
• Mol File: 3728-20-9.mol
• Article Data: 39

Chemical Properties

• Melting Point: 177-179℃
• Boiling Point: 330 °C at 760 mmHg
• Flash Point: 153.4 °C
• Appearance: White to off-white/Powder
• Vapor Pressure: 8.89E-05mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: H-D-TYR-OME HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-D-TYR-OME HCL(3728-20-9)
• EPA Substance Registry System: H-D-TYR-OME HCL(3728-20-9)

Safety Data

• Hazardous Substances Data: 3728-20-9(Hazardous Substances Data)

Usage

Description

H-D-TYR-OME HCL, also known as D-Tyrosine methyl ester hydrochloride, is a crystalline chemical compound that serves as an intermediate in the synthesis of various pharmaceuticals. It plays a crucial role in the development of medications targeting specific health conditions.

Uses

Used in Pharmaceutical Industry:
H-D-TYR-OME HCL is used as an intermediate in the synthesis of oxybutynin chloride (O868525) for its inhibitory effects on proliferation and suppression of gene expression in bladder smooth muscle cells. This application aids in the development of treatments for conditions related to bladder smooth muscle overactivity.
Additionally, H-D-TYR-OME HCL may be utilized in other applications within the pharmaceutical industry, depending on its chemical properties and potential interactions with other compounds. Its crystalline nature could make it suitable for various drug formulations and delivery systems.

InChI:InChI=1/C10H13NO3.ClH/c1-14-10(13)9(11)6-7-2-4-8(12)5-3-7;/h2-5,9,12H,6,11H2,1H3;1H/t9-;/m1./s1

Upstream product

• 67-56-1 methanol 
• 556-02-5 ?Tyr 
• 142847-18-5 N-(tert-butoxycarbonyl)tyrosine 
• 556-02-5 tyrosine 
• 3417-91-2 tyrosine methyl ester hydrochloride 
• 60-18-4 L-tyrosine 

Downstream Products

• 3978-80-1 Boc-Tyr-OH 
• 70642-86-3 N-(tert-butoxycarbonyl)-D-tyrosine 
• 188576-13-8 methyl 2-[(t-butoxycarbonyl)amino]-3-(4-hydroxyphenyl)propanoate 
• 1172-65-2 2-(2-tert-Butoxycarbonylamino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 77714-34-2 3-(4-Hydroxy-phenyl)-2-((Z)-3-oxo-propenylamino)-propionic acid methyl ester 
• 77714-34-2 3-(4-Hydroxy-phenyl)-2-((E)-3-oxo-propenylamino)-propionic acid methyl ester 
• 79397-31-2 2-[2-(4-Chloro-phenoxy)-acetylamino]-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 97654-03-0 Mal-Pab-Tyr-OMe 
• 101469-25-4 tyrosinamide 
• 69955-04-0 2-benzylideneamino-3-(4-hydroxyphenyl)-propionic acid methyl ester 
• 137957-18-7 2-(5,5-Dimethyl-3-oxo-cyclohex-1-enylamino)-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 556-02-5 tyrosine 
• 3410-66-0 D-tyrosine methyl ester 
• 60-18-4 L-tyrosine 

Relevant articles and documents

(2S, 3R)-3-amino-2-hydroxy-4-phenylbutyrylamide derivative as well as preparation method and application thereof

The invention discloses a (2S, 3R)-3-amino-2-hydroxy-4-phenylbutyrylamide derivative shown as a formula (I) or an optical isomer, a diastereomer and racemate mixture and pharmaceutically acceptable salt thereof as well as a preparation method and application of the (2S, 3R)-3-amino-2-hydroxy-4-phenylbutyrylamide derivative. It is shown by comparison of results of a positive control group and a model group on lymphedema prevention experiments that the compound disclosed in the invention shows obvious anti-edema activity.

NovelN-transfer reagent for converting α-amino acid derivatives to α-diazo compounds

A novel universalN-transfer reagent for direct and effective transformation of α-amino ketones, acetamides, and esters to the corresponding α-diazo products under mild basic conditions has been developed. This one-step synthetic approach not only allows for generation of α-substituted-α-diazo carbonyl compounds from α-amino acid derivatives but also permits preparation of α-diazo dipeptides fromN-terminal dipeptides (32 examples, up to 91%).

NOVEL TRF1 MODULATORS AND ANALOGUES THEREOF

Novel TRF1 modulators and analogues thereof. There is provided compounds of Formula I, wherein R, R1, R2 and X have meanings written in the description. Such compounds are useful as TRF1 inhibitors and, for that reason, as medicaments, in the treatment of cancer, particularly high cancer stem cell cancer like glioblastoma and lung cancer, and can be also useful for the development of additional TRF1 inhibitors and increasing knowledge about TRF1 activity.