36775-31-2 Usage
Description
(R)-(phenylacetyl)ammonium (1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulphonate, commonly known as methenamine mandelate, is a pharmaceutical compound that serves as a medication for the prevention of urinary tract infections. It is a salt derived from the combination of methenamine, an antibacterial agent, and mandelic acid, an aromatic alpha hydroxy acid. Methenamine mandelate functions by acidifying the urine, which in turn inhibits the growth of bacteria within the urinary tract.
Uses
Used in Pharmaceutical Industry:
Methenamine mandelate is used as a preventive medication for urinary tract infections. It is particularly effective in maintaining an acidic urine environment that discourages bacterial growth, thus helping to prevent infections from occurring or recurring.
Used in Urology:
In the field of urology, methenamine mandelate is utilized as a therapeutic agent for patients prone to urinary tract infections. It is prescribed to be taken orally, typically once or twice daily, to maintain a healthy urinary tract environment and reduce the risk of infection.
It is crucial to adhere to the dosage and administration guidelines provided by a healthcare professional when using methenamine mandelate to ensure its safety and effectiveness.
Check Digit Verification of cas no
The CAS Registry Mumber 36775-31-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,7,7 and 5 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 36775-31:
(7*3)+(6*6)+(5*7)+(4*7)+(3*5)+(2*3)+(1*1)=142
142 % 10 = 2
So 36775-31-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H16O4S.C8H9NO/c1-9(2)7-3-4-10(9,8(11)5-7)6-15(12,13)14;9-8(10)6-7-4-2-1-3-5-7/h7H,3-6H2,1-2H3,(H,12,13,14);1-5H,6H2,(H2,9,10)/t7?,10-;/m1./s1
36775-31-2Relevant articles and documents
Crystal structure-solubility relationships in optical resolution by diastereomeric salt formation of DL-phenylglycine with (1S)-(+)-camphor-10-sulfonic acid
Yoshioka, Ryuzo,Hiramatsu, Hajime,Okamura, Kimio,Tsujioka, Ikuko,Yamada, Shin-Ichi
, p. 2121 - 2128 (2007/10/03)
The experimentally-optimized optical resolution of DL-phenylglycine (PG) with (1S)-(+)-camphor-10-sulfonic acid ((+)-CS) afforded the crystalline D-PG·(+)-CS salt in 45.7% isolated yield and 98.8% optical purity. This excellent resolution has been studied by comparison of the crystal properties of the diastereomeric salt pair, D- and L-PG·(+)-CS. Thermoanalysis (DSC) of the less-soluble D-PG·(+)-CS showed a higher melting point and a larger enthalpy of fusion than those of the more-soluble L-PG·(+)-CS. The difference in the solubilities of the two salts in water is very large because the more-soluble L-PG·(+)-CS is freely soluble. The X-ray crystal structure of D-PG·(+)-CS shows a dense and stable molecular conformation of alternating PG cation layers and (+)-CS anion layers, whereas that of L-PG·(+)-CS shows a coarser molecular conformation consisting of characteristic holey vacancy layers, an important factor in its free solubility. The difference in the two characteristic structures could be closely related to the high efficiency of the resolution. A geometrical discussion of the (+)-CS molecule predicted that its excellent resolving ability may be due to its combining two structural functions; a hydrophilic flexible methanesulfonic acid site and a hydrophobic rigid camphor site.
