363-73-5

Basic information

• Product Name: 2,3,4,6-TETRAFLUOROANILINE
• Synonyms: 2,3,4,6-TETRAFLUOROANILINE;4-fluro-2-methylaniline;2,3,4,6-Tetrafluoroaniline 97%;2,3,4,6-Tetrafluoroaniline97%;(2,3,4,6-tetrafluorophenyl)amine;2,3,4,6-TETRAFLUOROA
• CAS NO: 363-73-5
• Molecular Formula: C6H3F4N
• Molecular Weight: 165.09
• EINECS: 206-659-2
• Product Categories: Indolines ,Indoles
• Mol File: 363-73-5.mol
• Article Data: 52

Chemical Properties

• Melting Point: 23-26
• Boiling Point: 65 °C20 mm Hg(lit.)
• Flash Point: 136 °F
• Appearance: /
• Density: 1.5 g/mL at 25 °C(lit.)
• Vapor Pressure: 2.02mmHg at 25°C
• Refractive Index: n20/D 1.462(lit.)
• PKA: 0.85±0.10(Predicted)
• CAS DataBase Reference: 2,3,4,6-TETRAFLUOROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,6-TETRAFLUOROANILINE(363-73-5)
• EPA Substance Registry System: 2,3,4,6-TETRAFLUOROANILINE(363-73-5)

Safety Data

• Hazard Codes: Xn,T
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-27-36/37/39-45
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 363-73-5(Hazardous Substances Data)

Usage

General Description

2,3,4,6-Tetrafluoroaniline is a chemical compound with the molecular formula C6H4F4N. It is a flammable, colorless to light brown liquid with a faint aromatic odor. 2,3,4,6-TETRAFLUOROANILINE is primarily used as an intermediate in the production of agricultural chemicals, dyes, and other specialty chemicals. It is also utilized as a building block in the synthesis of pharmaceuticals and other organic compounds. 2,3,4,6-Tetrafluoroaniline is known to be toxic if swallowed, inhaled, or absorbed through the skin, and can cause irritation to the skin, eyes, and respiratory system. It should be handled with care and in accordance with proper safety precautions.

InChI:InChI=1/C6H3F4N/c7-2-1-3(8)6(11)5(10)4(2)9/h1H,11H2

Upstream product

• 67-56-1 methanol 
• 106-89-8 epichlorohydrin 
• 314-41-0 1,2,3,5-tetrafluoro-4-nitrobenzene 
• 1634-04-4 tert-butyl methyl ether 
• 107-05-1 3-chloroprop-1-ene 
• 1072-61-3 4-chloromethyl-[1,3]dioxolane 
• 623-39-2 glycerol 1-monomethyl ether 

Downstream Products

• 80025-73-6 3-H-C₆F₄NHNH₂ 
• 76072-21-4 N-2,3,4,6-tetrafluorophenyl-N'-2,6-difluorobenzoylurea 
• 130020-24-5 C₁₆H₈F₄N₂O₂S 
• 332903-66-9 2-chloro-N-(2,3,4,6-tetrafluorophenyl)-N-p-tolyl-acetamide 
• 130020-18-7 3-(2,3,4,6-tetrafluorophenyl)imino-2H-indol-2-one 

Relevant articles and documents

On the mechanism of alcoholysis of allylic and benzylic alcohols and of epoxides in the presence of ceric ammonium nitrate

The methanolysis of allylic alcohols, benzylic tertiary alcohols and epoxides in the presence of a catalytic amount of ceric ammonium nitrate (CAN) is shown to be catalysed by protons generated from the oxidation of methanol. This reaction is also catalysed by Lewis acids.

Cellulose sulfate: An efficient heterogeneous catalyst for the ring-opening of epoxides with alcohols and anilines

Cellulose sulfate was synthesized by esterification of α-cellulose with concentrated sulfuric acid at ?10°C in ethanol. Cellulose is mainly sulfated on 3-, 6- and 3, 6-positions of the cellulose. It acts as a heterogeneous catalyst for the ring-opening of epoxides with alcohols or anilines and the Friedel-Crafts reaction between N-benzylindole and crotonaldehyde at room temperature. Methanolysis of cyclic epoxides, styrene oxide, terminal aliphatic epoxides, and glycidyl ethers were carried out using the catalyst (0.4–6.8 mg/mmol of epoxide) and afforded the corresponding products in 53–97% isolated yields after 10 min–24 h. Cellulose sulfate was successfully recycled and reused up to 3 catalytic cycles for the ring-opening of styrene oxide with methanol.

MBA-cross-linked poly(N-vinyl-2-pyrrolidone)/ferric chloride macromolecular coordination complex as a novel and recyclable Lewis acid catalyst: Synthesis, characterization, and performance toward for regioselective ring-opening alcoholysis of epoxides

A novel macromolecular-metal coordination complex, MBA-cross-linked PNVP/FeCl3 material was fabricated by immobilization of water intolerant ferric chloride onto the porous cross-linked poly(N-vinyl-2-pyrrolidone) carrier beads as a macromolecular ligand or carrier which was prepared by suspension free-radical copolymerization of N-vinyl-2-pyrrolidone (NVP) and N,N′-methylene bis-acrylamide (MBA) as a crosslinking agent in water. The obtained PNVP/FeCl3 was characterized by UV/vis and FT-IR spectroscopies, TGA, FE-SEM, EDX, and ICP techniques. This heterogenized version of ferric chloride is a convenient and safe alternative to highly water intolerant ferric chloride. The catalytic performance of (PNVP/FeCl3) as an efficient and recyclable polymeric Lewis acid catalyst was appropriately probed in the regio-and stereoselective nucleophilic ring opening of various epoxides with various alcohols in excellent yields with TOF up to 182.48 h?1 without generating any waste. The activity data indicate that this heterogeneous catalyst is very active and could be easily recovered, and reused at least six times without appreciable loss of activity indicating its stability under experimental conditions.