36210-76-1

Basic information

• Product Name: 2-Cyclohexyl-5-Methyl-2,4-dihydro-pyrazol-3-one
• Synonyms: 2-Cyclohexyl-5-Methyl-2,4-dihydro-pyrazol-3-one;1-cyclohexyl-3-methyl-1H-pyrazol-5(4H)-one;2-Cyclohexyl-2,4-dihydro-5-methyl-3H-pyrazol-3-one;1-Cyclohexyl-3-methyl-2-pyrazolin-5-one;1-Cyclohexyl-3-methylpyrazol-5-one;2-CYCLOHEXYL-5-METHYL-2,4-DIHYDRO-PYRAZOL-3-ONE(WXG03004)
• CAS NO: 36210-76-1
• Molecular Formula: C₁₀H₁₆N₂O
• Molecular Weight: 180.24684
• Mol File: 36210-76-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Cyclohexyl-5-Methyl-2,4-dihydro-pyrazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyclohexyl-5-Methyl-2,4-dihydro-pyrazol-3-one(36210-76-1)
• EPA Substance Registry System: 2-Cyclohexyl-5-Methyl-2,4-dihydro-pyrazol-3-one(36210-76-1)

Safety Data

• Hazardous Substances Data: 36210-76-1(Hazardous Substances Data)

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 24214-73-1 cyclohexylhydrazine hydrochloride 
• 141-97-9 ethyl acetoacetate 
• 6498-34-6 cyclohexylhydrazine 

Downstream Products

• 29938-69-0 5-chloro-1-cyclohexyl-3-methyl-1H-pyrazole 
• 553671-76-4 5-Chloro-1-cyclohexyl-3-methyl-4-nitro-1H-pyrazole 
• 634585-91-4 3'-[N'-(1-cyclohexyl-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene)-hydrazino]-2'-hydroxy-biphenyl-3-carboxylic acid 

Relevant articles and documents

Catalytic Enantioselective Addition of Pyrazol-5-ones to Trisubstituted Nitroalkenes with an N-Sulfinylurea Organocatalyst

The first example of enantioselective nitronate protonation following Michael addition of a carbon nucleophile to an α,β,β-trisubstituted nitroalkene is reported. An N-sulfinylurea catalyst was employed to catalyze the addition of a variety of 3-substitut

New series of antiprion compounds: Pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation

To find effective antiprion compounds, we synthesized and evaluated various pyrazolone derivatives. Seven of 19 compounds showed inhibition of PrP-res accumulation and the remarkably active compound 13 showed an IC50 value of 3 nM in both ScN2a and F3 cell lines. Findings from studies on physicochemical and biochemical properties suggest that the action mechanism of these compounds does not correlate with any antioxidant activities, any of hydroxyl radical scavenging activities, or any SOD-like activities.

PYRIDINYLPYRAZOLOPYRIMIDINONE DERIVATIVES AS PDE 7 INHIBITORS

To provide the compounds inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic disease, inflammatory disease or immunologic disease. The compound is pyridinylpyrazolopyrimidinone compound represented by the following formula (IA) or (IB): especially, R1 is cyclohexyl or cycloheptyl group, R2 is methyl; R3 is a group: -NR5R6 or -S(O)0-2R8; hydrogen atom; nitro group; cyano group; a halogen atom; heteroaryl group; and R4 is methoxy or ethoxy group.