35520-41-3 Usage
Description
3-(DIMETHYLAMINO)ACRYLONITRILE, also known as trans-3-(Dimethylamino)acrylonitrile, is an organic compound that has been studied for its potential vestibular toxicity. It is particularly investigated through CYP2E1-mediated metabolism in wild type (129S1) and CYP2E1-null mice. 3-(DIMETHYLAMINO)ACRYLONITRILE is of interest due to its possible effects on the vestibular system, which is responsible for balance and spatial orientation.
Uses
Used in Pharmaceutical Research:
3-(DIMETHYLAMINO)ACRYLONITRILE is used as a subject of study for [investigating vestibular toxicity] in [wild type (129S1) and CYP2E1-null mice]. The reason for this application is to understand the compound's potential effects on the vestibular system and its interaction with the CYP2E1 enzyme, which could have implications for the development of treatments or interventions related to balance and spatial orientation disorders.
Used in Toxicology Studies:
In the field of toxicology, 3-(DIMETHYLAMINO)ACRYLONITRILE is used as a test compound for [evaluating the role of CYP2E1-mediated metabolism] in [vestibular toxicity]. This application helps researchers to determine the compound's toxicity profile and its potential risks to human health, particularly in relation to the vestibular system.
Used in Drug Development:
3-(DIMETHYLAMINO)ACRYLONITRILE may also be used as a starting material or intermediate in [the synthesis of new pharmaceutical compounds] for [treating conditions related to the vestibular system]. The application reason is based on the compound's structural properties and its interaction with the CYP2E1 enzyme, which could potentially be leveraged to develop novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 35520-41-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,5,2 and 0 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 35520-41:
(7*3)+(6*5)+(5*5)+(4*2)+(3*0)+(2*4)+(1*1)=93
93 % 10 = 3
So 35520-41-3 is a valid CAS Registry Number.
InChI:InChI=1S/C5H8N2/c1-7(2)5-3-4-6/h3,5H,1-2H3/b5-3+
35520-41-3Relevant articles and documents
Formation of Enamines via Catalytic Dehydrogenation by Pincer-Iridium Complexes
Lu, Yansong J.,Zhang, Xiawei,Malakar, Santanu,Krogh-Jespersen, Karsten,Hasanayn, Faraj,Goldman, Alan S.
supporting information, p. 3020 - 3028 (2020/03/23)
Di-isopropylphosphino-substituted pincer-ligated iridium catalysts are found to be significantly more effective for the dehydrogenation of simple tertiary amines to give enamines than the previously reported di-t-butylphosphino-substituted species. It is
SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS
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Page/Page column 39; 40, (2014/10/29)
The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.
2-(arylimino-methyl)-3-dialkylaminoacrylonitriles, a process for their preparation and their use
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, (2008/06/13)
2-(Arylimino-methyl)-3-dialkylaminoacrylonitriles can be obtained by reaction of β-anilino-acrylonitriles with ortho-formamides. They are suitable as starting substances for the preparation of 4-amino-5-iminiummethylene-2-pyrimidines or 4-amino-5-formyl-2
