35416-67-2Relevant articles and documents
ALKYLATION OF CH ACIDS IN THE PRESENCE OF POTASSIUM CARBONATE. II. ALKYLATION OF ACETYLACETONE; ACETOACETIC ESTER; AND MALONIC ESTER WITH 1,4-DIHALOGENO-2-BUTENES
Vardapetyan, A. A.,Khachatryan, D. S.,Panosyan, G. A.,Morlyan, N. M.
, p. 2034 - 2037 (2007/10/02)
A convenient method was developed for the synthesis of derivatives of vinylcyclopropane and vinyldihydrofurane by the cycloalkylation of acetylacetone, acetoacetic ester, and malonic ester with 1,4-dihalogeno-2-butenes in the presence of potassium carbonate.The reaction of acetylacetone and acetoacetic ester with 1,4-dibromo-2,3-dimethyl-2-butene is regiospecific with the formation of the products from intramolecular O-alkylation.The isomerization of the 1-substituted 1-acyl-2-vinylcyclopropanes with the corresponding dihydrofurans is accelerated in the presence of catalytic amounts of cuprous chloride.