352535-82-1

Basic information

• Product Name: 3-CHLORO-2-FLUOROPHENYLBORONIC ACID
• Synonyms: 3-CHLORO-2-FLUOROBENZENEBORONIC ACID;3-CHLORO-2-FLUOROPHENYLBORONIC ACID;Te4052;3-Chloro-2-fluorophenylboronic aci;2-Fluoro-3-chlorophenylboronic acid;3-Chloro-2-fluorophenylboronic Acid (contains varying amounts of Anhydride);3-Chloro-2-fluorobenzeneboronic Acid (contains varying amounts of Anhydride)
• CAS NO: 352535-82-1
• Molecular Formula: C₆H₅BClFO₂
• Molecular Weight: 174.37
• Product Categories: blocks;BoronicAcids;FluoroCompounds;Aryl;Boronic Acids;Boronic Acids and Derivatives
• Mol File: 352535-82-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 223 °C (dec.)(lit.)
• Boiling Point: 315.1 °C at 760 mmHg
• Flash Point: 144.4 °C
• Appearance: white solid
• Density: 1.41 g/cm³
• Vapor Pressure: 0.000188mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: Keep Cold
• PKA: 7.35±0.58(Predicted)
• Water Solubility: Insoluble in water. Soluble in organic solvents.
• CAS DataBase Reference: 3-CHLORO-2-FLUOROPHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-2-FLUOROPHENYLBORONIC ACID(352535-82-1)
• EPA Substance Registry System: 3-CHLORO-2-FLUOROPHENYLBORONIC ACID(352535-82-1)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• Hazardous Substances Data: 352535-82-1(Hazardous Substances Data)

Usage

Description

3-CHLORO-2-FLUOROPHENYLBORONIC ACID is an organic compound that features a boronic acid functional group attached to a phenyl ring substituted with a chlorine atom at the 3rd position and a fluorine atom at the 2nd position. This unique structure endows it with versatile reactivity and properties, making it a valuable building block in various chemical and biological applications.

Uses

Used in Inorganic Synthesis:
3-CHLORO-2-FLUOROPHENYLBORONIC ACID is used as a synthetic building block for the creation of complex inorganic compounds. Its unique structure allows for selective functionalization and the formation of diverse chemical entities.
Used in Catalysis:
In the field of catalysis, 3-CHLORO-2-FLUOROPHENYLBORONIC ACID serves as a catalyst or a catalyst precursor, facilitating various chemical reactions with improved efficiency and selectivity.
Used in Analytical Chemistry:
3-CHLORO-2-FLUOROPHENYLBORONIC ACID is employed as a reagent or a derivatizing agent in analytical chemistry, enabling the detection, identification, and quantification of specific compounds or functional groups.
Used in Biological Systems:
In the realm of biology, 3-CHLORO-2-FLUOROPHENYLBORONIC ACID is utilized as a molecular probe or a building block for the development of bioactive molecules, targeting various biological processes and pathways.
Used in Pharmaceutical Industry:
3-CHLORO-2-FLUOROPHENYLBORONIC ACID is used as a key intermediate in the synthesis of pharmaceutical compounds, contributing to the development of new drugs with potential therapeutic applications.
Used in Material Science:
In material science, 3-CHLORO-2-FLUOROPHENYLBORONIC ACID is used as a component in the design and synthesis of novel materials with specific properties, such as improved conductivity, stability, or reactivity.

InChI:InChI=1/C6H5BClFO2/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,10-11H

Upstream product

• 144584-65-6 1-bromo-2-fluoro-3-chlorobenzene 
• 121-43-7 Trimethyl borate 
• 348-51-6 1-chloro-2-fluorobenzene 

Downstream Products

• 1231306-15-2 2-(((1s,4s)-4-((4-(3-chloro-2-fluorophenyl)-5-(2-(methylthio)ethyl)-3-phenyl-1H-pyrazol-1-yl)methyl)cyclohexyl)methoxy)acetic acid 
• 1439364-55-2 3-(3'-chloro-2'-fluorophenyl)pyrazine-2-carbonitrile 
• 1647008-46-5 8-chlorobenzo[b]naphtho[1,2-d]furan 

Relevant articles and documents

HETEROCYCLIC COMPOUND, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, AND LIGHTING DEVICE

A novel heterocyclic compound that can be used as a host material in which a light-emitting substance is dispersed. A light-emitting element having a long lifetime. A heterocyclic compound in which a substituted or unsubstituted dibenzo[f,h]quinoxalinyl group is bonded to a substituted or unsubstituted arylene group having 6 to 25 carbon atoms which is bonded to any one of the 8-11 positions of a substituted or unsubstituted benzo[b]naphtho[1,2-d]furan skeleton.

Design and application of a low-temperature continuous flow chemistry platform

A flow reactor platform technology applicable to a broad range of low temperature chemistry is reported. The newly developed system captures the essence of running low temperature reactions in batch and represents this as a series of five flow coils, each with independently variable volume. The system was initially applied to the functionalization of alkynes, Grignard addition reactions, heterocycle functionalization, and heteroatom acetylation. This new platform has then been used in the preparation of a 20-compound library of polysubstituted, fluorine-containing aromatic substrates from a sequential metalation-quench procedure and can be readily adapted to provide gaseous electrophile inputs such as carbon dioxide using a tube-in-tube reactor.

General method for the synthesis of substituted phenanthridin-6(5H)-ones using a KOH-mediated anionic ring closure as the key step

Substituted phenanthridin-6(5H)-ones were obtained in a two-step procedure involving a Suzuki cross-coupling reaction followed by a KOH-mediated anionic ring closure. The influence of the nature and the position of the substituents on the cyclization step were studied. This methodology offers a general and practical route to diversely substituted phenanthridin-6(5H)-ones.