352431-93-7

Basic information

• Product Name: ethyl trans-5-phenyl-3-trimethylsiloxypent-4-enoate
• Synonyms: ethyl trans-5-phenyl-3-trimethylsiloxypent-4-enoate
• CAS NO: 352431-93-7
• Molecular Weight: 292.45
• Mol File: 352431-93-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ethyl trans-5-phenyl-3-trimethylsiloxypent-4-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl trans-5-phenyl-3-trimethylsiloxypent-4-enoate(352431-93-7)
• EPA Substance Registry System: ethyl trans-5-phenyl-3-trimethylsiloxypent-4-enoate(352431-93-7)

Safety Data

• Hazardous Substances Data: 352431-93-7(Hazardous Substances Data)

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 
• 141-78-6 ethyl acetate 
• 18295-66-4 1-ethoxy-1-(trimethylsiloxy)ethene 
• 75-77-4 chloro-trimethyl-silane 
• 95728-97-5 (E)-ethyl 3-hydroxy-5-phenylpent-4-enoate 
• 4071-88-9 trimethylsilanyl-acetic acid ethyl ester 

Downstream Products

• 95728-97-5 (E)-ethyl 3-hydroxy-5-phenylpent-4-enoate 
• 352432-00-9 (1E,5E)-5-Ethoxy-1-phenylhepta-1,5-dien-3-ol 
• 352431-98-2 (1E,5Z)-5-Ethoxy-1-phenylhepta-1,5-dien-3-ol 

Relevant articles and documents

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The Mukaiyama aldol and Mukaiyama-Michael reactions promoted by commercially available molecular sieves

The Mukaiyama aldol reaction of silyl ketene acetals with aldehydes has been effected by using commercially available 4 molecular sieves (4 MS) as a promoter. Various silyl ketene acetals and silyl enol ethers have been shown to be effective nucleophiles

Stereoselective synthesis of β-hydroxycyclohexanones

We have developed a stereoselective route to β-hydroxycyclohexanones using the aldol reaction, the Takai alkylidenation, a novel anionic oxy-Cope rearrangement of acyclic enol ethers and an intramolecular aldol reaction. The stereoselectivity of the acid-induced, 6-(enolendo)-exo-trig, intramolecular, aldol reaction between an aldehyde and an enol ether has been investigated. The strong preference for an axial hydroxyl in the β-hydroxycyclohexanone products is explained in terms of an electrostatic interaction in the oxonium ion intermediate.