34898-30-1 Usage
Description
2-[4-(Trifluoromethyl)phenyl]-1H-imidazole is a chemical compound belonging to the imidazole family, characterized by a five-membered ring with two nitrogen atoms. It features a trifluoromethyl group attached to a phenyl ring, endowing it with unique chemical properties. 2-[4-(Trifluoromethyl)phenyl]-1H-imidazole is widely utilized in pharmaceutical research and drug development due to its potential as a bioactive molecule. Its structure and properties render it an ideal building block for synthesizing various biologically active compounds. Furthermore, it has been investigated for its potential antimicrobial, antifungal, and anticancer properties, positioning it as a promising candidate for further exploration in medicinal chemistry.
Uses
Used in Pharmaceutical Research and Drug Development:
2-[4-(Trifluoromethyl)phenyl]-1H-imidazole is used as a building block for synthesizing biologically active compounds, leveraging its unique chemical properties and structure to create novel pharmaceutical agents.
Used in Antimicrobial Applications:
In the field of antimicrobial research, 2-[4-(Trifluoromethyl)phenyl]-1H-imidazole is used as a potential antimicrobial agent, targeting various types of bacteria and contributing to the development of new antibiotics.
Used in Antifungal Applications:
2-[4-(Trifluoromethyl)phenyl]-1H-imidazole is employed as an antifungal agent, exhibiting activity against various fungal species, which is crucial for the development of new antifungal medications.
Used in Anticancer Applications:
2-[4-(Trifluoromethyl)phenyl]-1H-imidazole is used as a potential anticancer agent, with ongoing research exploring its ability to target and inhibit the growth of cancer cells, offering a new avenue for cancer treatment.
Used in Medicinal Chemistry:
In the realm of medicinal chemistry, 2-[4-(Trifluoromethyl)phenyl]-1H-imidazole is utilized for its potential to contribute to the discovery and development of new therapeutic agents, given its unique properties and structural attributes.
Check Digit Verification of cas no
The CAS Registry Mumber 34898-30-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,8,9 and 8 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 34898-30:
(7*3)+(6*4)+(5*8)+(4*9)+(3*8)+(2*3)+(1*0)=151
151 % 10 = 1
So 34898-30-1 is a valid CAS Registry Number.
34898-30-1Relevant articles and documents
Addressing hERG activity while maintaining favorable potency, selectivity and pharmacokinetic properties of PPARδ modulators
Lagu, Bharat,Senaiar, Ramesh S.,Kluge, Arthur F.,Mallesh,Ramakrishna,Bhat, Raveendra,Patane, Michael A.
, (2020/01/03)
One of the most commonly used strategies to reduce hERG (human ether-a-go-go) activity in the drug candidates is introduction of a carboxylic acid group. During the optimization of PPARδ modulators, some of the compounds containing a carboxylic acid were found to inhibit the hERG channel in a patch clamp assay. By modifying the basicity of the imidazole core, potent and selective PPARδ modulators that do not inhibit hERG channel were identified. Some of the modulators have excellent pharmacokinetic profiles in mice.
PPAR AGONISTS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF
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, (2017/11/10)
Provided herein are compounds and compositions useful in increasing PPARδ activity. The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).
COMPOUNDS FOR TREATMENT OF CANCER
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Paragraph 0041; 00356, (2011/10/03)
The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.