34552-15-3

Basic information

• Product Name: 2-Chloro-3-fluoro-5-methylpyridine
• Synonyms: 2-CHLORO-3-FLUORO-5-METHYLPYRIDINE;2-CHLORO-3-FLUORO-5-PICOLINE;6-Chloro-5-fluoro-3-picoline;2-Chloro-3-fluoro-5-picoline 2-Chloro-3-fluoro-5-methylpyridine
• CAS NO: 34552-15-3
• Molecular Formula: C₆H₅ClFN
• Molecular Weight: 145.56
• Product Categories: Pyridine;Pyridines;Fluorine series
• Mol File: 34552-15-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 29-30 °C
• Boiling Point: 92°C/25mmHg(lit.)
• Flash Point: 65.212 °C
• Appearance: White/Solid
• Density: 1.265 g/cm³
• Vapor Pressure: 1.014mmHg at 25°C
• Refractive Index: 1.504
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Methanol
• PKA: 0.35±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-3-fluoro-5-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-fluoro-5-methylpyridine(34552-15-3)
• EPA Substance Registry System: 2-Chloro-3-fluoro-5-methylpyridine(34552-15-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 34552-15-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-3-fluoro-5-methylpyridine is used as a key intermediate in the synthesis of various pharmaceuticals for its unique reactivity and structural features. It allows for the development of new drugs with tailored properties to address specific medical needs.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloro-3-fluoro-5-methylpyridine is utilized as a building block for the creation of novel agrochemicals. Its unique properties enable the design of effective compounds for crop protection and other agricultural applications.
Used in Organic Synthesis:
2-Chloro-3-fluoro-5-methylpyridine is employed as a versatile intermediate in organic synthesis, providing opportunities for tuning its properties to suit specific applications across various industries. Its presence in the molecule allows for diverse chemical transformations, making it a valuable tool in synthetic chemistry.

InChI:InChI=1/C6H5ClFN/c1-4-2-5(8)6(7)9-3-4/h2-3H,1H3

Upstream product

• 99268-30-1 2-fluoro-4-chloro-4-formylvaleronitrile 

Downstream Products

• 2036044-77-4 N-((3-fluoro-2'-methyl-[2,4'-bipyridin]-5-yl)methyl)-9H-carbazole-2-carboxamide 
• 950691-52-8 6-chloro-5-fluoro-3-pyridinecarbaldehyde 
• 38186-86-6 6-chloro-5-fluoronicotinic acid 
• 951652-82-7 2-chloro-5-chloromethyl-3-fluoropyridine 
• 904745-61-5 5-(bromomethyl)-2-chloro-3-fluoropyridine 

Relevant articles and documents

Synthesis of Halogenated Pyridines via the CuCl-Catalyzed Addition of Polyhaloacetonitriles to Olefins

Halogenated acetonitriles add smoothly to acrolein, methacrolein, and methacrolein dimethyl acetal in the presence of a catalytic amount of CuCl and triphenylphosphine, tri-n-butylphosphine, or triethylamine to give halogenated difunctional adducts.The adducts have been cyclized in high yields under acidic conditions to halogenated pyridines.

Halonitriles, their preparation and use to make halopyridines

Novel halonitriles, e.g., 2,4-dichloro-2-fluoro-5,5-dimethoxy-4-methylpentanenitrile, method of preparation and use to make halopyridines, some of which are novel, e.g., 2-chloro-3-fluoro-5-methylpyridine. These compounds are intermediates in the preparation of pharmaceutical and agricultural products.