345-70-0

Basic information

• Product Name: 3,3'-DIFLUOROBENZOPHENONE
• Synonyms: 3,3'-DIFLUOROBENZOPHENONE;3,3'-Difluorobenzophenone 99%;3,3'-Difluorobenzophenone99%;Bis(3-fluorophenyl)methanone
• CAS NO: 345-70-0
• Molecular Formula: C₁₃H₈F₂O
• Molecular Weight: 218.2
• Product Categories: C13 to C14;Carbonyl Compounds;Ketones
• Mol File: 345-70-0.mol
• Article Data: 14

Chemical Properties

• Melting Point: 59-61 °C(lit.)
• Boiling Point: 316℃
• Flash Point: 121℃
• Appearance: /
• Density: 1.239
• BRN: 1959286
• CAS DataBase Reference: 3,3'-DIFLUOROBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3'-DIFLUOROBENZOPHENONE(345-70-0)
• EPA Substance Registry System: 3,3'-DIFLUOROBENZOPHENONE(345-70-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 345-70-0(Hazardous Substances Data)

Usage

Uses

3,3′-Difluorobenzophenone may be used in chemical synthesis.

Upstream product

• 98586-21-1 bis(3-fluorophenyl)methanol 
• 456-48-4 3-Fluorobenzaldehyde 
• 1073-06-9 3-fluorobromobenzene 
• 6482-39-9 sodium methyl carbonate 
• 201230-82-2 carbon monoxide 
• 98-86-2 acetophenone 
• 119-61-9 benzophenone 
• 1711-07-5 3-fluorobenzoyl chloride 
• 768-35-4 3-fluorophenylboronic acid 
• 226260-01-1 3-fluoro-N-methoxy-N-methylbenzamide 
• 107337-71-3 3-fluorophenyllithium 

Downstream Products

• 120553-07-3 3.3-bis(3-Fluorophenyl)-2-propenal 
• 379-44-2 tris-(3-fluoro-phenyl)-methanol 
• 1025960-15-9 3,3-Bis-(3-fluoro-phenyl)-oxirane-2-carboxylic acid methyl ester 
• 98586-21-1 bis(3-fluorophenyl)methanol 
• 186496-31-1 3,3-bis(3-fluorophenyl)-3-hydroxypropionitrile 
• 1025962-01-9 3,3-bis-(3-fluoro-phenyl)-oxirane-2-carboxylic acid ethyl ester 
• 848561-43-3 (E)-(S)-4-{[Bis-(3-fluoro-phenyl)-methylene]-amino}-5-methyl-hex-2-enoic acid methyl ester 
• 848561-42-2 (E)-(S)-4-{[Bis-(3-fluoro-phenyl)-methylene]-amino}-6-methyl-hept-2-enoic acid methyl ester 
• 872053-62-8 9-(bis(3-fluorophenyl)methylene)-9H-fluorene 
• 848561-41-1 (E)-(S)-4-{[Bis-(3-fluoro-phenyl)-methylene]-amino}-5-phenyl-pent-2-enoic acid methyl ester 
• 848561-40-0 (E)-(S)-4-{[Bis-(3-fluoro-phenyl)-methylene]-amino}-pent-2-enoic acid methyl ester 
• 187842-09-7 3,3’-(chloromethylene)bis(fluorobenzene) 

Relevant articles and documents

Method for preparing symmetric diarylketone through catalytic oxidative carbonylation

The invention discloses a method for preparing symmetric diarylketone of a formula (I) as shown in the description. The method comprises the following steps: mixing arylboronic acid (II) (Ar-B(OH)2 (II)), a palladium catalyst, a promoter and an organic solvent in a reactor, introducing air and CO having a volume ratio of (7-19):1, reacting under the conditions of a pressure of 1-6 atm and a temperature of 30-80 DEG C for 8-16 hours, and performing after-treatment on the reaction solution, thereby obtaining the product symmetric diarylketone. According to the method disclosed by the invention,the air directly serves as an oxidizing agent to replace the O2 to be applied to oxidative carbonylation of the arylboronic acid, and the ratio of the air to CO is beyond an explosion limit. Therefore, the catalytic system is safe and economic. The palladium catalyst is small in dosage and simple in separation and can be recycled for several times. The method disclosed by the invention is mild inreaction condition, excellent in substrate suitability and high in yield.

Sodium Methyl Carbonate as an Effective C1 Synthon. Synthesis of Carboxylic Acids, Benzophenones, and Unsymmetrical Ketones

Reported is the synthesis of carboxylic acids, symmetrical ketones, and unsymmetrical ketones with selectivity achieved by exploiting the differential reactivity of sodium methyl carbonate with Grignard and organolithium reagents.

Temperature-controlled divergent synthesis of 4-alkoxy- or 4-alkenyl-chromanes via inverse electron-demand cycloaddition with in situ generated ortho-quinone methides

The temperature-controlled divergent synthesis of 4-alkoxy- or 4-alkenyl-chromanes via inverse electron-demand cycloaddition with in situ generated ortho-quinone methides under identical reaction conditions except for thermal condition has been developed. At room temperature, the reaction generated 4-methoxychromanes, whereas the reaction performed at room temperature to 100 °C gave 4-alkenylchromanes. Trifluoromethanesulfonic acid was efficiently suitable in the reaction to give the 4-substituted chromanes. This divergent synthetic strategy exhibits a new method giving carbon–carbon or carbon–oxygen bond by controlling the reaction temperature.

AZA-PYRIDONE COMPOUNDS AND USES THEREOF

Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compound. Examples of an orthomyxovirus viral infection include an influenza infection.

Ligand-Free Palladium-Catalyzed Oxidative Carbonylative Homocoupling of Arylboron Reagents at Ambient Pressure

Arylboronic acids or potassium aryltrifluoroborates were readily oxidatively carbonylated to their corresponding diaryl ketones in high yields with high selectivities by ligand-free palladium-catalyzed homocoupling at atmospheric pressure. This novel method employs molecular oxygen or iodine as the oxidant and offers an attractive alternative to transition-metal-based oxidant systems.

AZA-PYRIDONE COMPOUNDS AND USES THEREOF

Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compounds. Examples of an orthomyxovirus viral infection include an influenza infection.

One-pot synthesis of diarylmethanones through palladium-catalyzed sequential coupling and aerobic oxidation of aryl bromides with acetophenone as a latent carbonyl donor

A one-pot palladium-catalyzed synthesis of symmetrical and unsymmetrical diarylmethanones using acetophenone and aryl bromides as raw materials has been developed. In this reaction, acetophenone acts as a latent carbonyl donor and two pathways of palladium-catalyzed sequential coupling and aerobic oxidation are identified. The reaction is applicable to a spectrum of substrates and delivers the products in moderate to good yields. This method can be used for the synthesis of ketoprofen, a nonsteroidal anti-inflammatory drug, in a two-step procedure and 45% overall yield.

Palladium-catalyzed oxidative carbonylation for the synthesis of symmetrical diaryl ketones at atmospheric co pressure

A mild and efficient synthesis of symmetrical diaryl ketones by palladium-catalyzed oxidative carbonylation of arylboronic acids with carbon monoxide at atmospheric pressure is reported. Georg Thieme Verlag Stuttgart New York.

Kinetics of the solvolyses of fluoro-substituted benzhydryl derivatives: Reference electrofuges for the development of a comprehensive nucleofugality scale

A series of m-fluoro-substituted benzhydryl chloridcjs, bromides, mesylates and Losylates 1-X to 5-X were prepared and subjected to solvolysis reactions in various solvents. The observed first-order rate constants ks(25 °C) were found to follow the correlation equation log ks(25 °C) = Sf(Nf + Ef), which allowed us to determine the electrofugalily parameters Ef for these destabilized benzhydrylium cations and the nucleofugality parameters Nf, S f for a series of leaving group/ solvent combinations.

Novel inhibitors of the gardos channel for the treatment of sickle cell disease

Sickle cell disease (SCD) is a hereditary condition characterized by deformation of red blood cells (RBCs). This phenomenon is due to the presence of abnormal hemoglobin that polymerizes upon deoxygenation. This effect is exacerbated when dehydrated RBCs experience a loss of both water and potassium salts. One critical pathway for the regulation of potassium efflux from RBCs is the Gardos channel, a calcium-activated potassium channel. This paper describes the synthesis and biological evaluation of a series of potent inhibitors of the Gardos channel. The goal was to identify compounds that were potent and selective inhibitors of the channel but had improved pharmacokinetic properties compared to 1, Clotrimazole. Several triarylamides such as 10 and 21 were potent inhibitors of the Gardos channel (IC50 of 10 nM) and active in a mouse model of SCD. Compound 21 (ICA-17043) was advanced into phase 3 clinical trials for SCD.