34405-43-1Relevant articles and documents
Building Congested Ketone: Substituted Hantzsch Ester and Nitrile as Alkylation Reagents in Photoredox Catalysis
Chen, Wenxin,Liu, Zheng,Tian, Jiaqi,Li, Jin,Ma, Jing,Cheng, Xu,Li, Guigen
supporting information, p. 12312 - 12315 (2016/10/07)
For the first time, 4-alkyl Hantzsch esters were used to construct molecules with all-carbon quaternary centers by visible light-induced photoredox catalysis via transfer alkylation. Up to a 1500 h-1 turnover frequency was achieved in this reaction. Reactions of 4-alkyl Hantzsch nitriles as tertiary radical donors joined two contiguous all-carbon quaternary centers intermolecularly, and this chemistry was used to synthesize a common precursor of a class of hydroxysteroid dehydrogenase inhibitors.
Kinetic studies of the reaction of some nitrosoalkanes with nitrogen dioxide
Gowenlock, Brian G.,King, Boyd,Pfab, Josef,Witanowski, Michal
, p. 483 - 485 (2007/10/03)
The rates of the oxidation of some nitrosoalkanes (CH3)2C(CH2X)NO by nitrogen dioxide in carbon tetrachloride have been studied by stopped-flow techniques, and have been found to exhibit second order kinetics. Arrhenius parameters have been determined for the cases of X = H, CH3, C(CH3)3, C6H5, NO2, Cl and OCOCH3. Electron withdrawing substituents are found to decrease significantly the rates, which are generally much faster than the corresponding oxidation of nitrosoarenes. The results obtained are discussed with reference to the Hammett σ constants of the substituents X, and the atomic charges at the nitrogen atom as given by the TNDO/2 method, the geometries of the molecules having been optimised by the PM3 semi-empirical method.
THE NON-CHAIN RADICALOID C-ALKYLATION OF NITRONATE ANIONS: FURTHER EVIDENCE FOR THE MECHANISM
Katritzky, Alan R.,Chen, Jen-Luan,Marson, Charles M.,Maia, Angalamaria,Kashmiri, M. Akram
, p. 101 - 108 (2007/10/02)
The effects of the variation of solvent, pyridinium leaving group, N-substituent, and nitronate nucleophile have been studied in the C-alkylation of nitronate anions.These variations and studies of the effects of inhibitors, attempted entrainment reactions, and ESR work are all in accord with our previously suggested mechanism.