34403-46-8

Basic information

• Product Name: (4-AMINOMETHYL)BENZYL ALCOHOL HCL
• Synonyms: (4-AMINOMETHYL)BENZYL ALCOHOL HCL;(4-Aminomethyl)benzyl alcohol hydrochloride;(4-Aminomethyl-phenyl)-methanol hydrochloride;(4-Aminomethylphenyl)methanol HCl;(4-AMinoMethyl)benzyl alcohol HCl/(4-(aMinoMethyl)phenyl)Methanol hydrochloride;ASN 13654843;(4-Aminomethyl-phenyl)methanol hydrochloride≥ 95% (NMR)
• CAS NO: 34403-46-8
• Molecular Formula: C₈H₁₁NO*ClH
• Molecular Weight: 173.64
• Mol File: 34403-46-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 280°Cat760mmHg
• Flash Point: 123.2°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.00185mmHg at 25°C
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: (4-AMINOMETHYL)BENZYL ALCOHOL HCL(CAS DataBase Reference)
• NIST Chemistry Reference: (4-AMINOMETHYL)BENZYL ALCOHOL HCL(34403-46-8)
• EPA Substance Registry System: (4-AMINOMETHYL)BENZYL ALCOHOL HCL(34403-46-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 34403-46-8(Hazardous Substances Data)

Usage

Chemical Properties

Solid

Uses

(4-Aminomethyl)benzyl alcohol HCl

InChI:InChI=1/C8H11NO.ClH/c9-5-7-1-3-8(6-10)4-2-7;/h1-4,10H,5-6,9H2;1H

Upstream product

• 123986-64-1 tert-butyl 4-hydroxymethylbenzylcarbamate 
• 105-07-7 4-cyanobenzaldehyde 
• 1129-35-7 4-cyanobenzoic acid methyl ester 
• 439691-96-0 [4-(azidomethyl)phenyl]methanol 
• 51359-78-5 4-(bromomethyl)benzaldehyde 
• 71831-21-5 4-(bromomethyl)benzyl alcohol 

Downstream Products

• 725235-34-7 7-(3,5-dimethoxyphenylamino)-5-(4-hydroxymethylbenzylamino)imidazo[1,2-c]pyrimidine-8-carboxamide 
• 1365682-54-7 C₇₃H₉₁N₅O₁₂ 
• 1000297-83-5 C₃₉H₄₉N₃O₆ 
• 1365682-75-2 C₁₆H₁₆N₂O 
• 1365682-78-5 C₂₁H₂₄N₂O₃ 
• 1365682-81-0 C₂₁H₂₈N₂O₃ 
• 1365682-84-3 C₁₇H₁₉NO₃ 
• 1365682-88-7 C₂₂H₂₇NO₅ 
• 1365682-99-0 C₆₃H₇₉N₅O₈ 
• 1365683-07-3 C₇₃H₉₅N₅O₁₂ 
• 180397-92-6 N-(tert-butoxycarbonyl)bis[4-(hydroxymethyl)benzyl]amine 
• 199982-17-7 N-(tert-butoxycarbonyl)bis(4-formylbenzyl)amine 
• 948903-64-8 2,2,2-trifluoro-N-(3-(hydroxymethyl)benzyl)-acetamide 
• 948903-72-8 O⁶-[3-(Aminomethyl)benzyl]guanine 

Relevant articles and documents

Base-Catalyzed Hydrosilylation of Nitriles to Amines and Esters to Alcohols

Base-catalyzed hydrosilylation of nitriles to amines and esters to silylated alcohols is reported. This protocol tolerates electron-rich and electron-neutral olefins and works in the presence of basic functional groups (e. g. tertiary amines) but fails for acidic substrates, such as phenols and NH anilines. This catalytic system does not tolerate carbonyl groups, such as aldehydes, ketones, esters and carbamides, which are reduced to corresponding alcohols and amines. With the exact amount of silane, esters can be selectively reduced in the presence of nitriles, but the selectivity drops for the pairs ester/carboxamide and carboxamide/nitrile. Through competition experiments, the following preference in functional group reactivity was determined: ester > carboxamide > nitrile.

Hydrosilane Reduction of Nitriles to Primary Amines by Cobalt-Isocyanide Catalysts

Reduction of nitriles to silylated primary amines was achieved by combination of 1,1,3,3-tetramethyldisiloxane (TMDS) as the hydrosilane and a catalytic amount of Co(OPIV)2 (PIV = COtBu) associated with isocyanide ligands. The resulting silylated amines were subjected to acid hydrolysis or treatment with acid chlorides to give the corresponding primary amines or imides in good yields. One-pot synthesis of primary amides to primary amines with hydrosilanes was also achieved by iron-cobalt dual catalyst systems.

Sustainable organophosphorus-catalysed Staudinger reduction

A highly efficient and sustainable catalytic Staudinger reduction for the conversion of organic azides to amines in excellent yields has been developed. The reaction displays excellent functional group tolerance to functionalities that are otherwise prone to reduction, such as sulfones, esters, amides, ketones, nitriles, alkenes, and benzyl ethers. The green nature of the reaction is exemplified by the use of PMHS, CPME, and a lack of column chromatography.