342794-43-8

Basic information

• Product Name: AcetaMide, 2,2'-oxybis[N,N-dioctyl-
• Synonyms: AcetaMide, 2,2'-oxybis[N,N-dioctyl-;2,2'-Oxybis(N,N-dioctylacetamide);2,2'-Oxybis(N,N-dioctylaetaMide);N,N,N',N'-Tetraoctyldiglycolamide;N,N,N'N'-Tetraoctyl-3-oxapentanediamide;TODGA;2-[2-(dioctylamino)-2-oxoethoxy]-N,N-dioctylacetamide
• CAS NO: 342794-43-8
• Molecular Formula: C36H72N2O3
• Molecular Weight: 580.96848
• Mol File: 342794-43-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 652.6±40.0 °C(Predicted)
• Appearance: /
• Density: 0.910±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -0.53±0.70(Predicted)
• CAS DataBase Reference: AcetaMide, 2,2'-oxybis[N,N-dioctyl-(CAS DataBase Reference)
• NIST Chemistry Reference: AcetaMide, 2,2'-oxybis[N,N-dioctyl-(342794-43-8)
• EPA Substance Registry System: AcetaMide, 2,2'-oxybis[N,N-dioctyl-(342794-43-8)

Safety Data

• Hazardous Substances Data: 342794-43-8(Hazardous Substances Data)

Upstream product

• 1120-48-5 n-dioctylamine 
• 21062-20-4 diglycolyl chloride 
• 6634-17-9 diethyl diglycolate 
• 7040-23-5 dimethyl diglycolate 

Relevant articles and documents

Preparation of Diglycolamides via Schotten-Baumann Approach and Direct Amidation of Esters

Diglycolyl chlorides, commercially available or obtained from the corresponding dicarboxylic acids, have been converted into the corresponding diamides by reaction with a wide range of amines in an organic-aqueous biphasic system (Schotten-Baumann approach) in high yields. Treatment with poly(4-styrenesulfonic acid) afforded the pure compounds. Substituted diglycolyl diesters, obtained by coupling of commercial monoesters, were transformed directly in the corresponding diamides in the presence of aluminum trichloride as catalyst in good yields.

Novel process for synthesizing N,N,N',N'-tetraoctyl-3-oxyglutaramide

The invention provides a novel process for synthesizing N,N,N',N'-tetraoctyl-3-oxyglutaramide (TODGA). The novel process includes the steps of firstly, allowing diglycolic acid to have reaction with SOCl2 to generate diglycolic acyl chloride, and allowing the diglycolic acyl chloride to have reaction with amine to generate part of TODGA; secondly, removing components, which can be easily dissolvedin water, in the byproducts, and separating to obtain monooxaamide carboxylic acid; thirdly, allowing the monooxaamide carboxylic acid to have reaction with amine to generate part of TODGA again. Bythe novel process with the features of an existing process, high yield is achieved.