341524-89-8

Basic information

• Product Name: 2-[2-[(Z)-4-chloro-1,2-diphenyl-but-1-enoxy]ethoxy]ethanol
• Synonyms: 2-[2-[(Z)-4-chloro-1,2-diphenyl-but-1-enoxy]ethoxy]ethanol;fispemifene;Ospemifene Impurity 1 (Fispemifene)
• CAS NO: 341524-89-8
• Molecular Formula: C₂₆H₂₇ClO₃
• Molecular Weight: 0
• Mol File: 341524-89-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 512.2°C at 760 mmHg
• Flash Point: 263.5°C
• Appearance: /
• Density: 1.156g/cm³
• Vapor Pressure: 2.59E-11mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: 2-[2-[(Z)-4-chloro-1,2-diphenyl-but-1-enoxy]ethoxy]ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-[(Z)-4-chloro-1,2-diphenyl-but-1-enoxy]ethoxy]ethanol(341524-89-8)
• EPA Substance Registry System: 2-[2-[(Z)-4-chloro-1,2-diphenyl-but-1-enoxy]ethoxy]ethanol(341524-89-8)

Safety Data

• Hazardous Substances Data: 341524-89-8(Hazardous Substances Data)

Usage

Description

2-[2-[(Z)-4-chloro-1,2-diphenyl-but-1-enoxy]ethoxy]ethanol is a complex organic compound characterized by its unique molecular structure. It is a derivative of phenylbutene, featuring a chloro group and multiple ethoxy groups, which contribute to its chemical properties and potential applications.

Uses

Used in Pharmaceutical Industry:
2-[2-[(Z)-4-chloro-1,2-diphenyl-but-1-enoxy]ethoxy]ethanol is used as an active pharmaceutical ingredient for the treatment of male hypogonadism and male urinary tract symptoms. Its chemical structure allows it to interact with specific receptors in the body, helping to alleviate symptoms and improve overall health.
Used in Hormonal Regulation:
In the field of endocrinology, 2-[2-[(Z)-4-chloro-1,2-diphenyl-but-1-enoxy]ethoxy]ethanol is used as a selective estrogen receptor modulator (SERM) for the treatment of androgen deficiency and the maintenance of hormonal estrogen levels. Its ability to modulate estrogen receptor activity makes it a valuable tool in managing hormone-related conditions and maintaining overall hormonal balance.

InChI:InChI=1/C20H23ClO3/c21-12-11-19(17-7-3-1-4-8-17)20(18-9-5-2-6-10-18)24-16-15-23-14-13-22/h1-10,22H,11-16H2/b20-19-

Upstream product

• 341526-24-7 2-(2-{2-[4-((Z)-4-chloro-1,2-diphenylbut-1-enyl)phenoxy]ethoxy}ethoxy)tetrahydropyran 
• 1046827-45-5 (Z)-{2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)-phenoxy]-ethoxy}-acetic acid ethyl ester 

Relevant articles and documents

METHODS FOR IMMUNOMODULATION OF CANCER AND INFECTIOUS DISEASE THERAPY

The present invention provides methods for modulating the immune response of a subject to a therapeutic agent, the method comprising administering an effective amount of a triphenyl ethylene (TRIP) compound with an effective amount of the therapeutic agent. In particular embodiments, the TRIP compound enhances the immune response of the subject to the therapeutic agent. In some embodiments, the TRIP compound is administered in different dosing schedules to provide a biphasic immunomodulation effect.

METHOD FOR THE PREPARATION OF THERAPEUTICALLY VALUABLE TRIPHENYLBUTENE DERIVATIVES

The present invention concerns a method for the preparation of therapeutically valuable triphenylbutene derivatives, especially ospemifene or fispemifene.

Triphenylalkene derivatives and their use as selective estrogen receptor modulators

The invention provides novel selective estrogen receptor modulator compounds of the general formula: wherein R1 and R2, which are the same or different are a) H, halogen, OCH3, OH; or ?where X is O, NH or S; and n is an integer from 1 to 4; and R4 and R5, which are the same or different, are a 1 to 4 carbon alkyl, H, —CH2C≡CH or —CH2CH2OH; or R4 and R5 form an N-containing five- or six-membered ring or heteroaromatic ring; or c) —Y—(CH2)nCH2—O—R6 where Y is O, NH or S and n is an integer from 1 to 4; and R6 is H, —CH2CH2OH, or —CH2CH2Cl; or d) 2,3-dihydroxypropoxy, 2-methylsulfamylethoxy, 2-chloroethoxy, 1-ethyl-2-hydroxyethoxy, 2,2-diethyl-2-hydroxyethoxy or carboxymethoxy; and R3 is H, halogen, OH or —OCH3; stereoisomers thereof and their non-toxic pharmaceutically acceptable salts and esters and mixtures thereof, which compounds exhibit valuable pharmacological properties.