3386-18-3

Basic information

• Product Name: Nonaethylene glycol
• Synonyms: Nonaethylene glyco;NONAETHYLENE GLYCOL;3,6,9,12,15,18,21,24-octaoxahexacosane-1,26-diol;peg-9,polyoxyethylene(9),polyethyleneglycol450;2,2'-[1,2-Ethanediylbis[oxy(2,1-ethanediyl)oxy(2,1-ethanediyl)oxy(2,1-ethanediyl)oxy]]bis(ethanol);HO-PEG9-OH;PEG-9;2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
• CAS NO: 3386-18-3
• Molecular Formula: C₁₈H₃₈O₁₀
• Molecular Weight: 414.49
• EINECS: 222-206-1
• Product Categories: Ethylene Glycols;Ethylene Glycols & Monofunctional Ethylene Glycols
• Mol File: 3386-18-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 24.0-25.2 °C
• Boiling Point: 506.2°Cat760mmHg
• Flash Point: 26 °C
• Appearance: /
• Density: 1.115g/cm³
• Refractive Index: 1.46
• Storage Temp.: 2-8°C
• PKA: 14.06±0.10(Predicted)
• CAS DataBase Reference: Nonaethylene glycol(CAS DataBase Reference)
• NIST Chemistry Reference: Nonaethylene glycol(3386-18-3)
• EPA Substance Registry System: Nonaethylene glycol(3386-18-3)

Safety Data

• RTECS: RA5400000
• Hazardous Substances Data: 3386-18-3(Hazardous Substances Data)

Usage

Description

Nonaethylene glycol, also known as HO-PEG9-OH, is a polymer composed of ethylene glycol repeating units and terminal hydroxyl groups. It exhibits high water solubility due to the ethylene glycol units, and the hydroxyl groups allow for further derivatization of the compound.

Uses

Used in Pharmaceutical Industry:
Nonaethylene glycol is used as a reactant for the selective inhibition of human brain tumor cells through quantum-dot-based siRNA delivery. This application leverages its water solubility and reactivity to facilitate targeted cancer treatment.

InChI:InChI=1/C2H6O2.9C2H4/c3-1-2-4;9*1-2/h3-4H,1-2H2;9*1-2H2

Upstream product

• 112-26-5 1,2-bis(2-chloroethoxy)ethane 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 27712-99-8 1,3,6,9,2λ⁴-Tetraoxathia-2-cycloundecanon 
• 60389-48-2 C₂₄H₃₄O₆ 
• 105891-51-8 (2-{2-[2-(2-Chloro-ethoxy)-ethoxy]-ethoxy}-ethoxymethyl)-benzene 
• 57671-28-0 2-(2-{2-[2-(2-benzyloxyethoxy)ethoxy]ethoxy}ethoxy)ethanol 
• 86259-87-2 1-phenyl-2,5,8,11-tetraoxatridecan-13-ol 
• 112-60-7 Tetraethylene glycol 
• 19249-03-7 triethylene glycol di-(p-toluenesulfonate) 
• 133699-09-9 10,10,10-triphenyl-3,6,9-trioxadecan-1-ol 
• 80322-82-3 triethyleneglycol dimesylate 
• 669556-37-0 17-(tetrahydro-2H-pyran-2-yloxy)-3,6,9,12,15-pentaoxaheptadecyl 4-methylbenzenesulfonate 
• 60221-37-6 8-(1H-tetrahydropyran-2-yloxy)-3n₆³-dioxaoctan-1-ol 
• 77544-68-4 8-tosyloxy-3,6-dioxaoctanol 

Downstream Products

• 109635-68-9 51-Crown-17 
• 4445-03-8 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51-heptadecaoxa-tripentacontane-1,53-diol 
• 28780-45-2 α-hydro, ω-hydroxyheptacosa(oxyethylene) 
• 29928-00-5 hexatriaconta(ethylene glycol) 
• 361543-07-9 1,2-bis-(2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethane 
• 868594-48-3 26-(phenylmethyloxy)-3,6,9,12,15,18,21,24-octaoxahexaeicosan-1-ol 
• 62573-11-9 nonaethyleneglycol mono(p-toluenesulfonyl) ether 

Relevant articles and documents

Synthesis of oligo(ethylene glycol) toward 44-mer

A synthetic method for oligo(ethylene glycol) toward 44-mer (FW = 1956.35) is described. Reiteration of Williamson's ether synthesis and hydrogenation to remove protecting benzyl group affords desired oligo(ethylene glycol) toward 44-mer in moderate yields. The advantages in this method are use of commercially easily available materials as starting materials and procedures avoiding difficulty in purification of the products as much as possible.

An expedient synthesis of monodispersed oligo(ethylene glycols)

A convenient approach to the synthesis of oligo(ethylene glycols) under phase transfer conditions is described. Oligo(ethylene glycols) (x = 7-12) are obtained in excellent yields and high purity via modular, bi-directional elongation of readily available ethylene glycol bis-tosylates.