338-98-7 Usage
Description
21-Acetoxy-9-fluoro-11b,17-dihydroxypregna-1,4-diene-3,20-dione is a complex organic compound belonging to the class of steroids. It is characterized by its unique molecular structure, which includes a 9-fluoro substitution and an acetoxy group at the 21st position. 21-Acetoxy-9-fluoro-11b,17-dihydroxypregna-1,4-diene-3,20-dione is derived from the pregnane family of steroids and exhibits various biological activities due to its structural features.
Uses
Used in Pharmaceutical Industry:
21-Acetoxy-9-fluoro-11b,17-dihydroxypregna-1,4-diene-3,20-dione is used as a pharmaceutical agent for its anti-inflammatory and immunosuppressive properties. It is particularly effective in treating conditions that involve inflammation and immune system overactivity, such as autoimmune disorders and certain types of cancer.
Used in Veterinary Medicine:
In the veterinary field, 21-Acetoxy-9-fluoro-11b,17-dihydroxypregna-1,4-diene-3,20-dione is used as an anti-inflammatory drug, similar to Isoflupredone Acetate. It exhibits both glucocorticoid and mineralocorticoid activity, making it suitable for managing inflammation and immune responses in animals. However, it should be noted that its use may be associated with potential side effects, such as hypokalemia, and should be administered under the guidance of a veterinarian.
Used in Drug Delivery Systems:
Similar to gallotannin, 21-Acetoxy-9-fluoro-11b,17-dihydroxypregna-1,4-diene-3,20-dione can also be incorporated into drug delivery systems to enhance its therapeutic potential. By utilizing various carriers, such as organic and metallic nanoparticles, the compound's bioavailability and delivery can be improved, leading to more effective treatment outcomes.
Veterinary Drugs and Treatments
Isoflupredone acetate is a potent glucocorticoid and like other glucocorticoids
can be used for its antiinflammatory or immunosuppressive
effects. Labeled indications for isoflupredone include: adjunctive
treatment of bovine ketosis, alleviating pain and lameness
associated with musculoskeletal conditions, acute hypersensitivity
reactions, adjunctive treatment of overwhelming infections with
severe toxicity, shock, supportive therapy in the treatment of stress
conditions (e.g., surgery), dystocia, retained placenta, inflammatory
ocular conditions, snakebite and parturient paresis.
In horses, isoflupredone has been used parenterally to reduce
inflammation associated with recurrent airway obstruction (RAO,
“heaves”, COPD).
While the drug could be used in small animals, it is recommended
to use other glucocorticoid agents instead, where there has been
more experience and other approved products for dogs and cats are
available.
Check Digit Verification of cas no
The CAS Registry Mumber 338-98-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,3 and 8 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 338-98:
(5*3)+(4*3)+(3*8)+(2*9)+(1*8)=77
77 % 10 = 7
So 338-98-7 is a valid CAS Registry Number.
InChI:InChI=1/C23H29FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h6,8,10,16-18,27,29H,4-5,7,9,11-12H2,1-3H3
338-98-7Relevant articles and documents
Novel fluorinated antiinflammatory steroid with reduced side effects: Methyl 9α-fluoroprednisolone-16-carboxylate
McLean,Khalil,Heiman,Lee
, p. 476 - 480 (2007/10/02)
In an effort to test the hypothesis that 9α-fluorination of a steroidal antedrug would enhance receptor binding affinity and local antiinflammatory activity, without concomitantly increasing adverse systemic effects, a fluorinated analog, 10, of methyl 11β,21-dihydroxy-3,20-dioxo-1,4- pregnadiene-16α-carboxylate (DP16CM, 1) was synthesized and evaluated. In the acute rat croton oil-induced ear edema bioassay. 10 was found to be twice as potent as 1. This increase in topical potency was consistent with enhanced binding affinity of 10, relative to 1. The IC50 values for displacement of [3H] dexamethasone from glucocorticoid receptors of rat hepatoma tissue culture cells were 0.16, 1.2, and 0.03 μM for 10, 1, and prednisolone, respectively. Following multiple topical ID50 applications of prednisolone, 1, and its new fluorinated analog, 10, in the rat subacute croton oil- induced ear edema bioassay, only prednisolone exhibited significant untoward effects, such as reduction in relative thymus and adrenal weights, plasma corticosterone levels, and normal body weight gain. Thus, while fluorination of 1 enhanced its topical potency, there was not a concomitant increase in untoward systemic effects. This lack of adverse systemic effects is ostensibly due to the presence of the metabolically labile 16-carboxylate ester moiety.
