337505-04-1

Basic information

• Product Name: 2-[(5-AMINO-1,3,4-THIADIAZOL-2-YL)THIO]-N-(3-METHYLPHENYL)ACETAMIDE
• Synonyms: 2-[(5-AMINO-1,3,4-THIADIAZOL-2-YL)THIO]-N-(3-METHYLPHENYL)ACETAMIDE;ZERENEX E/5111279;acetamide, 2-[(5-amino-1,3,4-thiadiazol-2-yl)thio]-N-(3-me;2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(3-methylphenyl)ethanamide;EU-0040506;NCGC00098745-01;Oprea1_433665;Oprea1_770699
• CAS NO: 337505-04-1
• Molecular Formula: C11H12N4OS2
• Molecular Weight: 280.37
• Mol File: 337505-04-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[(5-AMINO-1,3,4-THIADIAZOL-2-YL)THIO]-N-(3-METHYLPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(5-AMINO-1,3,4-THIADIAZOL-2-YL)THIO]-N-(3-METHYLPHENYL)ACETAMIDE(337505-04-1)
• EPA Substance Registry System: 2-[(5-AMINO-1,3,4-THIADIAZOL-2-YL)THIO]-N-(3-METHYLPHENYL)ACETAMIDE(337505-04-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 337505-04-1(Hazardous Substances Data)

Usage

Contains a thioamide group

The presence of a thioamide group suggests potential as a pharmaceutical agent.

Contains an amino group

The presence of an amino group may contribute to the compound's pharmacological activity.

Contains a thiadiazole ring

Thiadiazole derivatives have been studied for their potential as antiviral, antibacterial, and antifungal agents.

Contains an amide group

The presence of an amide group suggests potential as a pharmaceutical agent, possibly as an analgesic or anti-inflammatory drug.

Contains a 3-methylphenyl group

The presence of a 3-methylphenyl group may contribute to the compound's pharmacological activity.

Potential medicinal properties

Further research is needed to fully understand the potential uses and effects of this chemical.

Upstream product

• 32428-61-8 2-chloro-N-(3-methylphenyl)acetamide 
• 2349-67-9 2-Amino-5-mercapto-1,3,4-thiadiazole 
• 108-44-1 1-amino-3-methylbenzene 

Relevant articles and documents

Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives incorporating benzisoselenazolone scaffold as potential antitumor agents

Background: Based on the biological signi-cance of benzisoselenazolone and 1,3,4-thiadiazole, a series of novel 1,3,4-thiadiazole derivatives incorporating benzisoselenazolone scaffold were designed and synthesized with ebselen as a lead compound. Methods: Meanwhile, their in vitro antitumor activities were evaluated against SMMC-7721, MCF-7 and A549 human cancer cell lines by CCK-8 assay. Results: The preliminary bioassay results demonstrated that all tested compounds 4a-q showed potent antitumor activities, and some compounds exhibited better effects than positive control ethaselen and 5-fluorouracil (5-FU) against various cancer cell lines. Furthermore, compounds 4b and 4m showed significant antitumor activities against SMMC-7721 cells with IC50 values of 1.89 and 1.89 μM, respectively. Compounds 4c and 4n displayed highly effective biological activities against MCF-7 cells with IC50 values of 2.88 and 2.28 μM, respectively. Compound 4i showed the best inhibitory effect against A549 cells with IC50 value of 1.76 μM. Conclusion: The pharmacological results suggest that the substituent groups of phenyl ring on the 1,3,4-thiadiazole are vital for modulating antitumor activities against various cancer cell lines.