33458-26-3 Usage
Description
ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE is an organic compound that serves as a crucial intermediate in the synthesis of various chemical and pharmaceutical products. It is characterized by its unique molecular structure, which includes a tetrahydropyrimidine ring fused with a phenyl group and a thioxo group, along with a carboxylate group attached to an ethyl ester. ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE is known for its potential applications in the development of new drugs and advanced materials.
Uses
Used in Organic Synthesis:
ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE is used as an organic synthesis intermediate for the creation of a wide range of chemical compounds. Its unique structure allows for various functional group transformations and reactions, making it a valuable building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE is used as a pharmaceutical intermediate in the development of new drugs. Its structural features make it a promising candidate for the design of novel therapeutic agents, particularly in the areas of medicinal chemistry and drug discovery.
Used in Laboratory Research and Development:
In the laboratory setting, ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE is employed as a key compound in the research and development process. It is utilized in the synthesis of new molecules and the investigation of their potential applications in various fields, including pharmaceuticals, materials science, and chemical engineering.
Used in Chemical and Pharmaceutical Production Process:
ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE plays a significant role in the chemical and pharmaceutical production process as a middle compound. It is involved in the synthesis of various active pharmaceutical ingredients (APIs) and other valuable chemical products, contributing to the advancement of the industry and the development of innovative solutions for various applications.
Synthesis
In a 10-mL round-bottom flask equipped with a condenser, a mixture of the aromatic aldehyde (1 mmol), ethyl acetoacetate (1 mmol), urea or thiourea (1.5 mmol) and [Dsbim]Cl (0.0376 g, 10 mol%) was stirred at 80 °C, and the resulting mixture was kept under continuous stirring for lengths of time as specified in Table 3, with the progress of the reaction was followed by TLC. After completion of the reaction, the mixture was cooled to room temperature, and 3 mL of water was added. The ionic liquid was dissolved in water and filtered for separation of the crude product. The separated product was washed twice with water (2 9 3 mL). For recycling the catalysts, after the solid products were thoroughly washed with water, the water containing the ionic liquid (IL is soluble in water) was evaporated under reduced pressure, and the ionic liquid was recovered and reused. The solid product was purified by a recrystallization procedure in ethanol. All of the desired product(s) were characterized by comparison of their physical data with those of known compounds. Entry: 13 Product: 4m; Yield: 90% Mp: 208-210°C; Lit. Mp: 205-206 [23]°C
Check Digit Verification of cas no
The CAS Registry Mumber 33458-26-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,4,5 and 8 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 33458-26:
(7*3)+(6*3)+(5*4)+(4*5)+(3*8)+(2*2)+(1*6)=113
113 % 10 = 3
So 33458-26-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H16N2O2S/c1-3-18-13(17)11-9(2)15-14(19)16-12(11)10-7-5-4-6-8-10/h4-8,12H,3H2,1-2H3,(H2,15,16,19)
33458-26-3Relevant articles and documents
Synthesis method of dihydropyrimidinone compound
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Paragraph 0034-0036; 0040-0041; 0044; 0070-0075; 0077, (2021/05/19)
The invention discloses a synthesis method of a dihydropyrimidone compound, which belongs to the technical field of organic synthesis, and comprises the following steps: by taking benzaldehyde or a derivative thereof, ethyl acetoacetate or acetylacetone a
Sulfonic Acid and Ionic Liquid Functionalized Covalent Organic Framework for Efficient Catalysis of the Biginelli Reaction
Yao, Bing-Jian,Wu, Wen-Xiu,Ding, Luo-Gang,Dong, Yu-Bin
, p. 3024 - 3032 (2021/02/05)
A quinoline-linked and ionic liquid-decorated covalent organic framework was prepared by incorporation of a multicomponent Povarov reaction and postsynthetic modification. The imidazolium and sulfonic acid-decorated COF-IM-SO3H can be a highly efficient B
Natural dolomitic limestone-catalyzed synthesis of benzimidazoles, dihydropyrimidinones, and highly substituted pyridines under ultrasound irradiation
Godugu, Kumar,Gundala, Trivikram Reddy,Mohinuddin Pinjari, Mohammad Khaja,Reddy Nallagondu, Chinna Gangi,Sanapareddy, Lakshmi Reddy,Sri Yadala, Venkata Divya
supporting information, p. 1881 - 1900 (2020/10/02)
Natural dolomitic limestone (NDL) is employed as a heterogeneous green catalyst for the synthesis of medicinally valuable benzimidazoles, dihydropyrimidinones, and highly functionalized pyridines via C–N, C–C, and C–S bond formations in a mixture of ethan
