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ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE is an organic compound that serves as a crucial intermediate in the synthesis of various chemical and pharmaceutical products. It is characterized by its unique molecular structure, which includes a tetrahydropyrimidine ring fused with a phenyl group and a thioxo group, along with a carboxylate group attached to an ethyl ester. ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE is known for its potential applications in the development of new drugs and advanced materials.

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  • ethyl 4-methyl-6-phenyl-2-sulfanylidene-3,6-dihydro-1H-pyrimidine-5-carboxylate

    Cas No: 33458-26-3

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  • 5-Pyrimidinecarboxylicacid, 1,2,3,4-tetrahydro-6-methyl-4-phenyl-2-thioxo-, ethyl ester

    Cas No: 33458-26-3

  • USD $ 18.0-20.0 / Kilogram

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  • 33458-26-3 Structure
  • Basic information

    1. Product Name: ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE
    2. Synonyms: 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER;ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBOXYLATE;ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE;AURORA KA-3499;BUTTPARK 61\40-96;Pyrimidine-5-carboxilyc acid, 1,2,3,4-tetrahydro-6-methyl-4-phenyl-2-t hione-, ethyl ester;6-Methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate;5-pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-6-methyl-4
    3. CAS NO:33458-26-3
    4. Molecular Formula: C14H16N2O2S
    5. Molecular Weight: 276.35
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 33458-26-3.mol
    9. Article Data: 118
  • Chemical Properties

    1. Melting Point: 180
    2. Boiling Point: 390.546 °C at 760 mmHg
    3. Flash Point: 189.996 °C
    4. Appearance: /
    5. Density: 1.256 g/cm3
    6. Vapor Pressure: 2.63E-06mmHg at 25°C
    7. Refractive Index: 1.621
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 11.33±0.70(Predicted)
    11. CAS DataBase Reference: ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE(CAS DataBase Reference)
    12. NIST Chemistry Reference: ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE(33458-26-3)
    13. EPA Substance Registry System: ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE(33458-26-3)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 33458-26-3(Hazardous Substances Data)

33458-26-3 Usage

Uses

Used in Organic Synthesis:
ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE is used as an organic synthesis intermediate for the creation of a wide range of chemical compounds. Its unique structure allows for various functional group transformations and reactions, making it a valuable building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE is used as a pharmaceutical intermediate in the development of new drugs. Its structural features make it a promising candidate for the design of novel therapeutic agents, particularly in the areas of medicinal chemistry and drug discovery.
Used in Laboratory Research and Development:
In the laboratory setting, ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE is employed as a key compound in the research and development process. It is utilized in the synthesis of new molecules and the investigation of their potential applications in various fields, including pharmaceuticals, materials science, and chemical engineering.
Used in Chemical and Pharmaceutical Production Process:
ETHYL 6-METHYL-4-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE plays a significant role in the chemical and pharmaceutical production process as a middle compound. It is involved in the synthesis of various active pharmaceutical ingredients (APIs) and other valuable chemical products, contributing to the advancement of the industry and the development of innovative solutions for various applications.

Synthesis

In a 10-mL round-bottom flask equipped with a condenser, a mixture of the aromatic aldehyde (1 mmol), ethyl acetoacetate (1 mmol), urea or thiourea (1.5 mmol) and [Dsbim]Cl (0.0376 g, 10 mol%) was stirred at 80 °C, and the resulting mixture was kept under continuous stirring for lengths of time as specified in Table 3, with the progress of the reaction was followed by TLC. After completion of the reaction, the mixture was cooled to room temperature, and 3 mL of water was added. The ionic liquid was dissolved in water and filtered for separation of the crude product. The separated product was washed twice with water (2 9 3 mL). For recycling the catalysts, after the solid products were thoroughly washed with water, the water containing the ionic liquid (IL is soluble in water) was evaporated under reduced pressure, and the ionic liquid was recovered and reused. The solid product was purified by a recrystallization procedure in ethanol. All of the desired product(s) were characterized by comparison of their physical data with those of known compounds. Entry: 13 Product: 4m; Yield: 90% Mp: 208-210°C; Lit. Mp: 205-206 [23]°C

Check Digit Verification of cas no

The CAS Registry Mumber 33458-26-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,4,5 and 8 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 33458-26:
(7*3)+(6*3)+(5*4)+(4*5)+(3*8)+(2*2)+(1*6)=113
113 % 10 = 3
So 33458-26-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H16N2O2S/c1-3-18-13(17)11-9(2)15-14(19)16-12(11)10-7-5-4-6-8-10/h4-8,12H,3H2,1-2H3,(H2,15,16,19)

33458-26-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 6-methyl-4-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate

1.2 Other means of identification

Product number -
Other names ethyl 6-methyl-2-thioxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:33458-26-3 SDS

33458-26-3Relevant articles and documents

Deep eutectic solvent assisted synthesis of dihydropyrimidinones/thionesviaBiginelli reaction: theoretical investigations on their electronic and global reactivity descriptors

Shaibuna,Kuniyil, Muhammed Jeneesh Kariyottu,Sreekumar

, p. 20765 - 20775 (2021/11/23)

Deep eutectic solvents formed from hydrated metal chlorides and hydrogen bond donors (Type 4) were prepared and their catalytic activity was compared for the synthesis of dihydropyrimidinones/thionesviaBiginelli reaction at room temperature. The one-pot m

Sulfonic Acid and Ionic Liquid Functionalized Covalent Organic Framework for Efficient Catalysis of the Biginelli Reaction

Yao, Bing-Jian,Wu, Wen-Xiu,Ding, Luo-Gang,Dong, Yu-Bin

, p. 3024 - 3032 (2021/02/05)

A quinoline-linked and ionic liquid-decorated covalent organic framework was prepared by incorporation of a multicomponent Povarov reaction and postsynthetic modification. The imidazolium and sulfonic acid-decorated COF-IM-SO3H can be a highly efficient B

Synthesis method of dihydropyrimidinone compound

-

Paragraph 0034-0036; 0040-0041; 0044; 0070-0075; 0077, (2021/05/19)

The invention discloses a synthesis method of a dihydropyrimidone compound, which belongs to the technical field of organic synthesis, and comprises the following steps: by taking benzaldehyde or a derivative thereof, ethyl acetoacetate or acetylacetone a

A highly efficient one-pot multicomponent synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones catalyzed by strontium pyroarsenate nano-plates

Esmaeili, Rozhin,Kafi-Ahmadi, Leila,Khademinia, Shahin

, (2020/05/01)

The present work describes the one-pot multicomponent synthesis of heterocyclic 3,4-dihydropyrimidin-2-(1H)-ones and thiones (DHPMs) under solvent-free conditions by Sr2As2O7 nanocatalyst. Sr2As2Osub

Natural dolomitic limestone-catalyzed synthesis of benzimidazoles, dihydropyrimidinones, and highly substituted pyridines under ultrasound irradiation

Godugu, Kumar,Gundala, Trivikram Reddy,Mohinuddin Pinjari, Mohammad Khaja,Reddy Nallagondu, Chinna Gangi,Sanapareddy, Lakshmi Reddy,Sri Yadala, Venkata Divya

supporting information, p. 1881 - 1900 (2020/10/02)

Natural dolomitic limestone (NDL) is employed as a heterogeneous green catalyst for the synthesis of medicinally valuable benzimidazoles, dihydropyrimidinones, and highly functionalized pyridines via C–N, C–C, and C–S bond formations in a mixture of ethan

Dihydropyrimidinones: Efficient one-pot green synthesis using Montmorillonite-KSF and evaluation of their cytotoxic activity

Alharthi, Fahad A.,Alsalme, Ali,Dar, Bashir A.,Farooq, Saleem,Hamid, Abid,Hussain, Aashiq,Koul, S.

, p. 42221 - 42234 (2020/12/09)

A simple, efficient, cost-effective, recyclable and green approach has been developed for the synthesis of new dihydropyrimidinone analogs via the Biginelli reaction. The methodology involves a multicomponent reaction catalyzed by "HPA-Montmorillonite-KSF"as a reusable and heterogeneous catalyst. This method gives an efficient and much improved modification of the original Biginelli reaction, in terms of yield and short reaction times under solvent free conditions. All the derivatives were subjected to cytotoxicity screening against a panel of four different human cancer cell lines viz. colon (Colo-205), prostate (PC-3), leukemia (THP-1) and lung (A549) to check their effect on percentage growth. MTT [3-(4,5-dimethylthiazol-yl)-diphenyl tetrazoliumbromide] cytotoxicity assay was employed to check IC50 values. Of the synthesized analogs, 16a showed the best activity with IC50 of 7.1 ± 0.8, 13.1 ± 1.4, 13.8 ± 0.9 and 14.7 ± 1.1 μM against lung (A549), leukemia (THP-1), prostate (PC-3) and colon (Colo-205) cancer lines, respectively. The 16a analog was further checked for its effect on cancer cell properties through clonogenic (colony formation) and scratch motility (wound healing) assays and thereby was found that it reduced both the colony formation and migratory properties of the lung cancer cell line (A549). Further, molecular docking studies were performed with 16a to show its binding mode. This journal is

Efficient one-pot synthetic methods for the preparation of 3,4-dihydropyrimidinones and 1,4-dihydropyridine derivatives using BNPs?SiO2(CH2)3NHSO3H as a ligand and metal free acidic heterogeneous nano-catalyst

Bahrami, Kiumars,Khodamorady, Minoo,Sohrabnezhad, Samira

, (2020/01/23)

Heterocyclic compounds with biological and pharmacological activates like 3,4-dihydropyrimidin-2-(1H)-ones and 1,4-dihydropyridines have attracted great interest. Boehmite nanoparticles functionalized with silylpropyl sulfamic acid (BNPs?SiO2(C

Polymeric imidazolium ionic liquid-tagged manganese Schiff base complex: an efficient catalyst for the Biginelli reaction

Mashhoori, Mahboobeh-Sadat,Sandaroos, Reza,Zeraatkar Moghaddam, Ali

, p. 4939 - 4954 (2020/09/01)

Abstract: In this study, a new organometallic catalyst including polymeric imidazolium ionic liquid-functionalized Mn(III) Schiff base complex (PIL-SB-Mn(III)) was prepared and characterized using various analyses like FTIR, H-NMR, FE-SEM, EDX, TGA, and ICP-OES. Then, the applications of catalyst were tested in the synthesis of 3,4-dihydropyrimidine-2(1H)-one/thiones under solvent-free conditions. This polymeric ionic liquid catalyst can carry out the Biginelli reaction in less than an hour in good to excellent yields. The recovered catalyst has been characterized by FTIR and EDX analyses; heterogeneous nature of this catalyst has been confirmed successfully. Graphic abstract: [Figure not available: see fulltext.].

Air-stable zirconium (IV)-salophen perfluorooctanesulfonate as a highly efficient and reusable catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones under solvent-free conditions

Li, Ningbo,Wang, Yijun,Liu, Feijun,Zhao, Xin,Xu, Xinhua,An, Quan,Yun, Keming

, (2020/01/22)

An air-stable complex of zirconium (IV)-salophen perfluorooctanesulfonate (1) was successfully synthesized by reacting Zr (salphen)Cl2 and C8F17SO3Ag. Complex 1 was characterized and studied by different techniq

Tuning the Biginelli reaction mechanism by the ionic liquid effect: The combined role of supported heteropolyacid derivatives and acidic strength

Freitas, Elon F.,Souza, Roberto Y.,Passos, Saulo T. A.,Dias, José A.,Dias, Silvia C. L.,Neto, Brenno A. D.

, p. 27125 - 27135 (2019/09/13)

Herein, a combination of heteropolyacids and ionic liquids as a catalytic system was studied for the Biginelli multicomponent reaction; the positive ionic liquid effect associated with the acidic strength of zeolite-supported heteropolyacids made this com

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