33302-52-2

Basic information

• Product Name: Benzene, 1-chloro-3-(2-propynyloxy)-
• Synonyms: m-Chlorphenylpropargylether;3-chlorophenyl propargyl ether;m-Chlorphenylpropargylaether
• CAS NO: 33302-52-2
• Molecular Formula: C9H7ClO
• Molecular Weight: 166.607
• Mol File: 33302-52-2.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: Benzene, 1-chloro-3-(2-propynyloxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-chloro-3-(2-propynyloxy)-(33302-52-2)
• EPA Substance Registry System: Benzene, 1-chloro-3-(2-propynyloxy)-(33302-52-2)

Safety Data

• Hazardous Substances Data: 33302-52-2(Hazardous Substances Data)

Upstream product

• 108-43-0 3-monochlorophenol 
• 106-96-7 propargyl bromide 
• 6165-76-0 propargyl p-toluenesulfonate 
• 107-19-7 propargyl alcohol 

Downstream Products

• 135034-72-9 4-((3-chlorophenoxy)methyl)-1-phenyl-1H-1,2,3-triazole 
• 93986-35-7 1-chloro-3-((3-phenylprop-2-yn-1-yl)oxy)benzene 
• 2985-80-0 4-chloro-2-hydroxybenzophenone 

Relevant articles and documents

Water-Tolerant ortho-Acylation of Phenols

A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments.

Iron-Mediated Cyclization of 1,3-Diynyl Propargyl Aryl Ethers with Dibutyl Diselenide: Synthesis of Selenophene-Fused Chromenes

The synthesis of selenophene-fused chromene derivatives starting from 1,3-diynyl propargyl aryl ethers is reported herein. The method is based on carbon-carbon, carbon-selenium, selenium-carbon and carbon-selenium bonds formation in a one-pot protocol, using iron(III) chloride and dibutyl diselenide as promoters. The same reaction conditions were applied to propargyl anilines leading to the formation of 1-(butylselanyl)-selenophene quinolines. The results showed that the dilution and temperature of substrate addition had a crucial influence in the products obtained. When the substrates were added at room temperature, in the absence of a solvent, a mixture of products was obtained, whereas the slowly addition (15 min) of starting materials, as a dichloromethane solution, at 0 °C led to the product formation in good yields. The mechanistic study indicates that the cooperative action between iron(III) chloride and dibutyl diselenide was essential to promote the cyclization, whereas separately none of them was effective in promoting the cyclization. We proved the synthetic utility of heterocycles obtained in the Suzuki cross coupling reaction, giving the corresponding cross-coupled products in good yields. In addition, the organoselenium moiety was removed from the structures of products by using n-butyllithium. (Figure presented.).

Preparation of novel 1,2,3-triazole furocoumarin derivatives via click chemistry and their anti-vitiligo activity

The extracts of Psoralea corylifolia?L. were often used for the repigmentation of leukoderma (vitiligo) in traditional Uygur medicine thousands years ago. Nowadays, its active ingredient, furocoumarins, has been clinically applied since it exhibited stron