33284-21-8

Basic information

• Product Name: Ethanone, 2,2,2-trifluoro-1-(3-pyridinyl)- (9CI)
• Synonyms: Ethanone, 2,2,2-trifluoro-1-(3-pyridinyl)- (9CI);3-trifluoroacetypyridine;3-(Trifluoroacetyl)pyridine;2,2,2-trifluoro-1-(pyridin-3-yl)ethanone;2,2,2-trifluoro-1-(pyridin-3-yl)ethan-1-one;3-(Trifluoroacetyl)pyridine monohydrate;2,2,2-Trifluoro-1-(pyridin-3-yl);2,2,2-TRIFLUORO-1-(PYRIDIN-3-YL)ETHANONE HCL H2O
• CAS NO: 33284-21-8
• Molecular Formula: C7H4F3NO
• Molecular Weight: 175.1079696
• Product Categories: ACETYLHALIDE
• Mol File: 33284-21-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 197.93 °C at 760 mmHg
• Flash Point: 73.506 °C
• Appearance: /
• Density: 1.341 g/cm³
• Vapor Pressure: 0.369mmHg at 25°C
• Refractive Index: 1.446
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1?+-.0.10(Predicted)
• CAS DataBase Reference: Ethanone, 2,2,2-trifluoro-1-(3-pyridinyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2,2,2-trifluoro-1-(3-pyridinyl)- (9CI)(33284-21-8)
• EPA Substance Registry System: Ethanone, 2,2,2-trifluoro-1-(3-pyridinyl)- (9CI)(33284-21-8)

Safety Data

• Hazardous Substances Data: 33284-21-8(Hazardous Substances Data)

Usage

Uses

3-(Trifluoroacetyl)pyridine is used as medical intermediates.

InChI:InChI=1/C7H4F3NO/c8-7(9,10)6(12)5-2-1-3-11-4-5/h1-4H

Upstream product

• 59-67-6 nicotinic acid 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 75-46-7 trifluoromethan 
• 93-60-7 methyl 3-pyridinecarboxylate 
• 138624-99-4 2,2,2-trifluoro-1-(pyridin-3-yl)ethan-1-ol 
• 456-56-4 phenyl trifluoromethylsulfide 
• 350-03-8 methyl-3-pyridylketone 
• 383-63-1 ethyl trifluoroacetate, 
• 626-55-1 3-Bromopyridine 
• 360-92-9 N,N-diethyl-2,2,2-trifluoroacetamide 

Relevant articles and documents

Trifluoromethylation of Benzoic Acids: An Access to Aryl Trifluoromethyl Ketones

The trifluoromethylation of benzoic acids with TMSCF3 was achieved through nucleophilic substitution with the use of anhydrides as an in situ activating reagent. Under the reaction conditions, a wide range of carboxylic acids including the bioactive ones worked well, thus providing a facile and efficient method for preparing aryl trifluoromethyl ketones from the readily available starting materials.

Fluoroform: an Efficient Precursor for the Trifluoromethylation of Aromatic Esters by Sodium Diisopropylamide with Trialkylamines

The trifluoromethanide anion is the postulated key intermediate in nucleophilic trifluoromethylation reactions. It is believed to be incompatible with Na+ cation due to the strong Na–F bond. However, herein we demonstrate that it could be prepared for the first time. Trialkylamines can be used as cation chelating agents to stabilize the isolated –CF3 ion to realize trifluoromethylation reaction. With this strategy, trifluoromethyl aromatic ketones could be effectively synthesized from fluoroform and aromatic esters with diisopropyl aminosodium (NaDA) and trialkylamines.

High-Pressure-Mediated Asymmetric Organocatalytic Hydroxyalkylation of Indoles with Trifluoromethyl Ketones

An enantioselective hydroxyalkylation of indoles and 7-azaindole with trifluoromethyl ketones was found to be effectively promoted under high-pressure conditions with a low loading of Cinchona alkaloids (e.g., 1–3 mol% of cinchonidine). Chiral tertiary alcohols containing a trifluoromethyl group were obtained at 9 kbar with good yield and enantioselectivity up to 89%, whereas usually merely traces of products were detected at atmospheric pressure. (Figure presented.).

CYSTEINE PROTEASE INHIBITORS

To provide a compound having an excellent cysteine protease inhibitory effect, and to provide a drug for treatment or prevention of the disease selected from the group consisting of osteoporosis, osteoarthritis, chronic rheumatoid arthritis, Paget's disea

Process for preparing alpha-halogenated retones

The invention concerns a method for preparing α-halogenated ketones from secondary α-halogenated alcohols. More particularly, the invention concerns the preparation of α-trihalogenated ketones from secondary α-trihalogenated alcohols. The method for prepa

New catalytic oxidation of trifluoromethyl carbinols by a ruthenium(II) complex

The first catalytic oxidation of trifluoromethyl carbinols has been accomplished by a novel ruthenium(II) complex using sodium periodate as an oxidant. Trifluoromethyl ketones were obtained under mild conditions and in excellent yields. (C) 2000 Elsevier Science Ltd.

Process for preparing trifluoromethyl ketones

A process is described for preparing trifluoromethyl ketones of the formula I STR1 where R has the given meanings, wherein an alcohol of the formula II STR2 is reacted with a compound of the formula IV where n has the given meaning.

Chemoselective Trifluoromethylation of Methyl Esters Using an Et3GeNa/C6H5SCF3 Combination: Efficient Synthesis of Trifluoromethyl Ketones

Various trifluoromethyl ketones were synthesized from the corresponding methyl esters by effective nucleophilic trifluoromethylation using an Et3GeNa/C6H5SCF3 combination. This trifluoromethylation proceeded che

Fungicidal Pyridine Derivatives, IV. α-Trifluoromethyl-3-pyridinemethanols

The synthesis of a series of the title compounds is described applying the addition of 3-pyridyllithium to appropriate trifluoromethylalkanones (path 1) and addition of lithiumorganyls to 2,2,2-trifluoro-1-(3-pyridyl)-ethanone (path 2), respectively.Keywords.Fungicides; α-Trifluoromethyl-pyridinemethanols.

Synthesis and Spectral Studies on 3-Nicotinyl-trifluoroacetonates of Lanthanide Elements

Diaquotris (3-nicotinyltrifluoroacetonates) of lanthanum, preseodymium, neodymium, samarium, gadolinium, dysprosium, holmium and erbium have been synthesized.The dihydrated chelates have been converted into anhydrous analogues by azeotropic removal of water.Three M-O bands and one M-N band have been observed in all the chelates.Absorption spectra of these chelates in benzene provide sufficient evidence for the existence of some covalency in the metal-ligand bond.Nephelauxetic ratio (β) covalency parameter (δ) and bonding parameter (b1/2) of these chelates have been calculated.