33157-07-2

Basic information

• Product Name: N-(4-{[(2-amino-4a-hydroxy-5-methyl-4-oxo-1,4,4a,5,6,7-hexahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
• CAS NO: 33157-07-2
• Molecular Formula: C₂₀H₂₅N₇O₇
• Molecular Weight: 475.4552
• Mol File: 33157-07-2.mol
• Article Data: 0

Chemical Properties

• Density: 1.66g/cm³
• Refractive Index: 1.735
• CAS DataBase Reference: N-(4-{[(2-amino-4a-hydroxy-5-methyl-4-oxo-1,4,4a,5,6,7-hexahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-{[(2-amino-4a-hydroxy-5-methyl-4-oxo-1,4,4a,5,6,7-hexahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid(33157-07-2)
• EPA Substance Registry System: N-(4-{[(2-amino-4a-hydroxy-5-methyl-4-oxo-1,4,4a,5,6,7-hexahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid(33157-07-2)

Safety Data

• Hazardous Substances Data: 33157-07-2(Hazardous Substances Data)

Usage

Description

N-(4-[(2-amino-4a-hydroxy-5-methyl-4-oxo-1,4,4a,5,6,7-hexahydropteridin-6-yl)methyl]aminobenzoyl)-L-glutamic acid, commonly known as methotrexate, is a medication with a complex chemical structure that serves as an antimetabolite. It is utilized in the treatment of various conditions, including certain cancers, autoimmune diseases, and ectopic pregnancies, by inhibiting the growth of cancer cells and suppressing the immune system.

Uses

Used in Oncology:
Methotrexate is used as a chemotherapy drug for the treatment of certain types of cancer. It works by interfering with the synthesis of DNA and RNA, thereby inhibiting the proliferation of cancer cells and slowing down tumor growth.
Used in Autoimmune Diseases:
In the treatment of autoimmune diseases, methotrexate is used as a disease-modifying antirheumatic drug (DMARD). It helps to reduce inflammation and suppress the immune system, alleviating symptoms and slowing the progression of conditions such as rheumatoid arthritis.
Used in Dermatology:
Methotrexate is used as an immunosuppressive agent for the treatment of severe psoriasis. It helps to control the overactive immune response that leads to skin inflammation and the rapid growth of skin cells.
Used in Obstetrics:
Methotrexate is used in the management of ectopic pregnancies, where it can help to terminate the pregnancy by inhibiting the growth of the trophoblast cells, which are essential for the development of the placenta.
However, due to its potential toxic effects on the liver, kidneys, and bone marrow, methotrexate must be closely monitored by a healthcare professional during treatment to ensure its safe and effective use.