33070-32-5

Basic information

• Product Name: 5-Bromo-2,2-difluorobenzodioxole
• Synonyms: 5-BROMO-2,2-DIFLUORO-1,3-BENZODIOXOLE;5-BROMO-2,2-DIFLUORO-BENZO[1,3]DIOXOLE;5-BROMO-2,2-DIFLUOROBENZODIOXOLE;4-Bromo-1,2-[(difluoromethylene)dioxy]benzene~3,4-[(Difluoromethylene)dioxy]bromobenzene;5-Bromo-2,2-difluoro-1,3-benzodioxole, 97+%;3,4-[(difluoromethylene)dioxy]bromobenzene;4-bromo-1,2-[(difluoromethylene)dioxy]benzene;5-Bromo-2,2-difluoro-1,3-benzodioxole 98%
• CAS NO: 33070-32-5
• Molecular Formula: C₇H₃BrF₂O₂
• Molecular Weight: 237
• Product Categories: Heterocycles series
• Mol File: 33070-32-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 78-79°C 20mm
• Flash Point: >75°C
• Appearance: /
• Density: 1,74 g/cm3
• Vapor Pressure: 0.00187mmHg at 25°C
• Refractive Index: 1.4967
• Storage Temp.: Room temperature.
• Solubility: Miscible with hexane.
• BRN: 1425209
• CAS DataBase Reference: 5-Bromo-2,2-difluorobenzodioxole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2,2-difluorobenzodioxole(33070-32-5)
• EPA Substance Registry System: 5-Bromo-2,2-difluorobenzodioxole(33070-32-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36-41
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 33070-32-5(Hazardous Substances Data)

Usage

Description

5-Bromo-2,2-difluorobenzodioxole is an organic compound characterized by the presence of a bromine atom at the 5-position, two fluorine atoms at the 2-position, and a benzodioxole ring structure. This unique molecular arrangement endows it with specific chemical properties that make it a versatile building block in various chemical reactions and applications.

Uses

Used in Organic Synthesis:
5-Bromo-2,2-difluorobenzodioxole is used as a precursor in organic synthesis, providing a foundation for the creation of more complex molecules and compounds. Its unique structure allows for further functionalization and modification, making it a valuable component in the synthesis of a wide range of organic compounds.
Used in Pharmaceutical Industry:
As an intermediate in active pharmaceutical ingredients, 5-Bromo-2,2-difluorobenzodioxole plays a crucial role in the development of new drugs and therapeutic agents. Its specific chemical properties enable the design and synthesis of novel pharmaceutical compounds with potential applications in treating various diseases and medical conditions.
Used in Agrochemical Industry:
5-Bromo-2,2-difluorobenzodioxole also serves as an intermediate in the agrochemical field, contributing to the development of new pesticides, herbicides, and other agricultural chemicals. Its unique structure allows for the creation of compounds with enhanced efficacy and selectivity, improving crop protection and yield.
Used in Dye Industry:
In the dyestuff field, 5-Bromo-2,2-difluorobenzodioxole is utilized as an intermediate for the synthesis of various dyes and pigments. Its chemical properties enable the production of dyes with specific color characteristics, stability, and performance, catering to the diverse requirements of different industries such as textiles, plastics, and printing.
Overall, 5-Bromo-2,2-difluorobenzodioxole is a versatile and valuable compound with applications spanning across various industries, including pharmaceuticals, agrochemicals, and dyestuff. Its unique structure and properties make it an essential component in the development of new and innovative products.

InChI:InChI=1/C12H10FN/c13-10-6-8-12(9-7-10)14-11-4-2-1-3-5-11/h1-9,14H

Upstream product

• 663934-09-6 (6-bromo-2,2-difluoro-1,3-benzodioxol-4-yl)triethylsilane 
• 1583-59-1 2,2-difluoro-1,3-benzodioxole 
• 7439-89-6 iron 
• 17345-77-6 1-bromo-3,4-dihydroxybenzene 
• 663934-04-1 (7-bromo-2,2-difluoro-1,3-benzodioxol-4-yl)triethylsilane 
• 663934-00-7 (2,2-difluoro-1,3-benzodioxol-4-yl)triethylsilane 

Downstream Products

• 313681-67-3 2,2-difluorobenzo[d][1,3]dioxole-5-sulfonyl chloride 
• 190903-71-0 (2,2-difluoro-1,3-benzodioxol-5-yl)boronic acid 
• 1211539-82-0 2, 2-difluorobenzo[d][1,3]dioxol-5-ol 
• 517874-23-6 2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Relevant articles and documents

Deprotonation-Triggered Heavy-Halogen Migrations as a Key to the Structural Elaboration of 2,2 -Difluoro-1,3-benzodioxole

Although proton abstraction from the 4-position of 2,2-difluoro-1,3-benzodioxole occurs with exceptional ease, lithiation of the more-remote 5-position can only be brought about if no oxygen-adjacent site remains unoccupied. Thus, unlike 4-bromo-2,2-diflu

Synthesis method of (2,2-difluorobenzo[d][1,3]dioxy-5-yl)methanol

The invention discloses a preparation method of (2,2-difluorobenzo[d][1,3]dioxo-5-yl)methanol as a fine chemical intermediate. The method is simple and feasible, lower in cost, and suitable for preparing (2,2-difluorobenzo[d][1,3]dioxo-5-yl)methanol through industrial production.

PROCESS FOR THE PREPARATION OF HALOGENATED DERIVATIVES OF AROMATIC ETHERS

The present invention relates to the process for the preparation of halogenated derivatives of aromatic ethers.