329710-76-1

Basic information

• Product Name: 2-(trifluoromethoxy)ethyl trifluoromethanesulfonate
• Synonyms: 2-(trifluoromethoxy)ethyl trifluoromethanesulfonate;Trifluoromethanesulfonic acid 2-(trifluoromethoxy)ethyl ester
• CAS NO: 329710-76-1
• Molecular Formula: C₄H₄F₆O₄S
• Molecular Weight: 262.1275792
• Mol File: 329710-76-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 141.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.627±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-(trifluoromethoxy)ethyl trifluoromethanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(trifluoromethoxy)ethyl trifluoromethanesulfonate(329710-76-1)
• EPA Substance Registry System: 2-(trifluoromethoxy)ethyl trifluoromethanesulfonate(329710-76-1)

Safety Data

• Hazardous Substances Data: 329710-76-1(Hazardous Substances Data)

Usage

Physical state

colorless, volatile liquid

Odor

characteristic pungent

Reactivity

highly reactive

Use

commonly used as a trifluoromethylating reagent in organic synthesis

Function

a strong electrophile for the introduction of the trifluoromethyl group

Applications

utilized in the synthesis of pharmaceuticals and agrochemicals

Safety

should be handled with caution and appropriate safety measures due to its highly reactive nature.

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 329710-73-8 1-(trifluoromethoxy)-2-[2-trifluoromethoxyethoxyethane] 
• 329710-75-0 1-(2-trifluoromethoxy-ethoxy)-pentane 
• 329710-74-9 1-(2-ethoxy-ethoxy)-2-trifluoromethoxy-ethane 

Downstream Products

• 329710-82-9 N-[2-(trifluoromethoxy)ethyl]phthalimide 
• 1845-25-6 (-)-(2R,3R,5R)-2-hydroxy-3-pinanone 
• 1845-25-6 (1S,2S,5S)-(-)-2-hydroxypinan-3-one 
• 1346498-24-5 methyl 3-methoxy-4-(2-(trifluoromethoxy)ethoxy)benzoate 
• 888227-14-3 4-[(2-trifluoromethoxy-ethyl)-(2-trifluoromethyl-benzyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Synthesis and physical chemical properties of 2-amino-4-(trifluoromethoxy)butanoic acid-a CF3O-containing analogue of natural lipophilic amino acids

2-Amino-2-(trifluoromethoxy)butanoic acid (O-trifluoromethyl homoserine) was synthesized as a racemate and in both enantiomeric forms. The measured pKa and log D values establish the compound as a promising analogue of natural aliphatic amino acids.

INHIBITORS OF MONOAMINE UPTAKE

N,N-disubstituted 4-amino-piperidines of the general Formula (I) are inhibitors of the uptake of serotonin and/or norepinephrine and/or dopamine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.