329-53-3

Basic information

• Product Name: N^α,N^ε-bis(trifluoroacetyl)-L-lysine
• Synonyms: N^α,N^ε-bis(trifluoroacetyl)-L-lysine
• CAS NO: 329-53-3
• Molecular Weight: 338.207
• Mol File: 329-53-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N^α,N^ε-bis(trifluoroacetyl)-L-lysine(CAS DataBase Reference)
• NIST Chemistry Reference: N^α,N^ε-bis(trifluoroacetyl)-L-lysine(329-53-3)
• EPA Substance Registry System: N^α,N^ε-bis(trifluoroacetyl)-L-lysine(329-53-3)

Safety Data

• Hazardous Substances Data: 329-53-3(Hazardous Substances Data)

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 16079-52-0 sodium salt of L-lysine 

Downstream Products

• 132776-83-1 Nα,Nε-bis(trifluoroacetyl)-L-Lys-O-p-nitrophenyl ester 
• 849586-31-8 (S)-2,6-Bis-(2,2,2-trifluoro-acetylamino)-hexanoic acid [2-(4-vinyl-benzylcarbamoyl)-ethyl]-amide 
• 132776-84-2 5'-O--5-<3-oxo-3-<<2-<<1-oxo-2,6-bis<(trifluoroacetyl)amino>hexyl>amino>-ethyl>amino>propyl>-2'-deoxyuridine 
• 132776-85-3 5'-O--5-<3-oxo-3-<<2-<<1-oxo-2,6-bis<(trifluoroacetyl)amino>hexyl>amino>-ethyl>amino>propyl>-2'-deoxyuridine 3'-O-(N,N-diisopropylamino)(β-cyanoethoxy)phosphine 
• 1258859-53-8 N,N'-bistrifluoroacetyl-chloro-lisdexamfetamine 
• 1275611-26-1 5-[3-{2,6-bis(2,2,2-trifluoroacetylamino)hexanoyl}-1-propynyl]-5'-O-(4,4'-dimethoxytrityl) LNA uridine 
• 1242674-89-0 2'-O-[N₂,N₆-bis(trifluoroacetyl)lysyl]aminohexyl-5'-O-(4,4'-dimethoxytrityl)adenosine 

Relevant articles and documents

N-trifluoroacyl lysine derivatives in the synthesis of L-lysyl-L-glutamic acid

Conditions were developed for simultaneous preparation of N a-trifluoroacetyl-L-lysine and N α,N a-bis(trifluoroacetyl)-L-lysine at overall conversion of initial lysine monohydrochloride up to 82%. By reaction of dimethyl L-glutamate with N α,N a-bis(trifluoroacetyl)-L-lysyl chloride in the presence of triethylamine or with N α- carboxyanhydride of N a-trifluoroacetyl-L-lysine with subsequent removing protecting groups in the formed dipeptides by treating with water-ethanol solution of sodium hydroxide we obtained L-lysyl-L-glutamic acid. Physicochemical characteristics of samples obtained coincided with characteristics of L-lysyl-L-glutamic acid described in the literature thus suggesting that no racemization occurred either at the stage of peptide bond formation or at deprotection.