328956-61-2

Basic information

• Product Name: 3-Chloro-5-fluorophenylboronic acid
• Synonyms: 3-CHLORO-5-FLUOROPHENYLBORONIC ACID;3-CHLORO-5-FLUOROBENZENEBORONIC ACID;AKOS BRN-0721;3-Chloro-5-fluorobenzeneboronic acid 97%;3-Chloro-5-fluorobenzeneboronicacid97%;3-Chloro-5-fluorophenlyboronic acid;3-Chloro-5-fluorobenzeneboronic acid ,98%;3-Chloro-5-fluorobenzeneboroni
• CAS NO: 328956-61-2
• Molecular Formula: C₆H₅BClFO₂
• Molecular Weight: 174.37
• Product Categories: blocks;BoronicAcids;FluoroCompounds;Boronic Acids
• Mol File: 328956-61-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: >200°C
• Boiling Point: 308.135 °C at 760 mmHg
• Flash Point: 140.156 °C
• Appearance: /
• Density: 1.416 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Methanol
• PKA: 6.52±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3-Chloro-5-fluorophenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-5-fluorophenylboronic acid(328956-61-2)
• EPA Substance Registry System: 3-Chloro-5-fluorophenylboronic acid(328956-61-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 328956-61-2(Hazardous Substances Data)

Usage

Description

3-Chloro-5-fluorophenylboronic acid is an organic compound that serves as a crucial intermediate in various chemical reactions and synthesis processes. It is characterized by its white solid appearance and is known for its reactivity in organic synthesis, making it a valuable compound in the fields of pharmaceuticals, agrochemicals, and dyestuff.

Uses

Used in Organic Synthesis:
3-Chloro-5-fluorophenylboronic acid is used as an important intermediate in organic synthesis for the production of various chemical compounds. Its unique structure allows for versatile reactions, making it a valuable building block in the creation of complex molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-Chloro-5-fluorophenylboronic acid is utilized as a key component in the development of new drugs. Its reactivity and structural diversity enable the synthesis of novel pharmaceutical compounds with potential therapeutic applications.
Used in Agrochemicals:
3-Chloro-5-fluorophenylboronic acid is also employed in the agrochemical industry for the synthesis of various agrochemical products, such as pesticides and herbicides. Its role in creating effective and targeted compounds contributes to the development of more efficient and environmentally friendly solutions for agricultural challenges.
Used in Dyestuff Industry:
In the dyestuff industry, 3-Chloro-5-fluorophenylboronic acid is used as a vital raw material for the production of dyes and pigments. Its unique chemical properties allow for the creation of a wide range of colors and hues, enhancing the diversity of dyes available for various applications.
Used in Suzuki Reaction:
3-Chloro-5-fluorophenylboronic acid is also used in the Suzuki reaction, a widely employed method for the formation of carbon-carbon bonds in organic chemistry. This reaction is particularly useful in the synthesis of complex organic molecules, including those found in pharmaceuticals and agrochemicals, further highlighting the versatility and importance of 3-Chloro-5-fluorophenylboronic acid in the field of chemistry.

Upstream product

• 121-43-7 Trimethyl borate 
• 33863-76-2 1-bromo-3-chloro-5-fluorobenzene 

Downstream Products

• 1208385-76-5 C₃₀H₁₈ClF₁₁O 
• 1617545-52-4 2-[6-(3-chloro-5-fluoro-phenyl)-pyrazin-2-ylamino]-butan-1-ol 
• 1207965-40-9 3-[2-(3-chloro-5-fluorobenzyl)-1-benzothiophen-7-yl]-N-(2-methoxyethyl)benzamide 
• 1379806-97-9 (4R,4a′S,10a′S)-8′-(3-chloro-5-fluorophenyl)-4a′-methyl-3′,4′,4a′,10a′-tetrahydro-1′H,5H-spiro[oxazole-4,10′-pyrano-[4,3-b]chromen]-2-amine 
• 1056417-83-4 5-(3-chloro-5-fluorophenyl)-N-(3,4-dimethoxybenzyl)-2,3'-bipyridine-3-carboxamide 
• 1338091-96-5 2-amino-7′-(3-chloro-5-fluorophenyl)-1,3′,3′-trimethyl-3′,4′-dihydro-2′H-spiro[imidazole-4,1′-naphthalen]-5(1H)-one 
• 1430416-40-2 N-(2′-amino-1′,2,2-trimethyl-5′-oxo-1′,5′-dihydrospiro-[chroman-4,4′-imidazole]-6-yl)-5-methylfuran-2-carboxamide 
• 1266520-39-1 5-(3-chloro-5-fluorophenyl)-4-(3-cyano-5-fluorophenyl)-1,3-thiazole-2-carboxylic acid 
• 1266520-05-1 4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-carboxylic acid 
• 1266520-59-5 5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)-1,3-thiazole-2-carboxylic acid 
• 1266520-44-8 5-(3-chloro-5-fluorophenyl)-4-(3-cyano-4-fluorophenyl)-1,3-thiazole-2-carboxylic acid 
• 1313196-62-1 ethyl 5-(tert-butoxymethyl)-1-[2-(3-chloro-5-fluorobenzyl)-4-fluoro-1-benzothiophen-7-yl]-3-methyl-1H-pyrazole-4-carboxylate 
• 1379805-26-1 2''-amino-7'-(3-chloro-5-fluorophenyl)-1''-methyl-2',4',4'a,5'',6'',9'a-hexahydro-1'H,1''H-dispiro[1,3-dioxolane-2,3'-xanthene-9',4''-pyrimidine]-6''-one 
• 1379809-07-0 tert-butyl N-[7'-(3-chloro-5-fluorophenyl)-1''-methyl-6''-oxo-2',4',4'a,5'',6'',9'a-hexahydro-1'H,1''H-dispiro[1,3-dioxolane-2,3'-xanthene-9',4''-pyrimidine]-2''-yl]carbamate 

Relevant articles and documents

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