3272-42-2

Basic information

• Product Name: 1-(methylsulfinyl)-3-nitrobenzene
• CAS NO: 3272-42-2
• Molecular Formula: C₇H₇NO₃S
• Molecular Weight: 185.2004
• Mol File: 3272-42-2.mol
• Article Data: 40

Chemical Properties

• Boiling Point: 363.3°C at 760 mmHg
• Flash Point: 173.5°C
• Density: 1.43g/cm³
• Vapor Pressure: 3.81E-05mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: 1-(methylsulfinyl)-3-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(methylsulfinyl)-3-nitrobenzene(3272-42-2)
• EPA Substance Registry System: 1-(methylsulfinyl)-3-nitrobenzene(3272-42-2)

Safety Data

• Hazardous Substances Data: 3272-42-2(Hazardous Substances Data)

Usage

General Description

1-(methylsulfinyl)-3-nitrobenzene, also known as methyl 3-nitrophenyl sulfide, is a chemical compound with the molecular formula C7H7NO2S. It is an organic compound that contains a nitro group which is bonded to a benzene ring. The presence of the methylsulfinyl group adds an additional sulfur and oxygen atom to the molecule. 1-(methylsulfinyl)-3-nitrobenzene is commonly used in organic synthesis and can be used as an intermediate in the manufacturing of pharmaceuticals, dyes, and other organic compounds. It is important to handle this chemical with caution as it may pose certain health and environmental risks if not properly managed.

Upstream product

• 2524-76-7 1-(methylsulfanyl)-3-nitrobenzene 
• 67-68-5 dimethyl sulfoxide 
• 99-09-2 3-nitro-aniline 
• 132016-29-6 methyl 3-nitrophenyl sulfoxide 

Downstream Products

• 132016-29-6 (+)-(S)-3-methylsulfinylnitrobenzene 
• 146143-21-7 (+)-(R)-3-methylsulfinylnitrobenzene 
• 16671-77-5 3-nitrophenyl thiocyanate 
• 1093847-78-9 (RS)-N-(ethoxycarbonyl)-S-(3-{[5-bromo-pyrimindin-2-yl]amino}phenyl)-S-methylsulfoximide 
• 1002358-21-5 (RS)-S-(3-nitrophenyl)-N-(isopropylcarbamoyl)-S-methyl-sulfoximide 
• 1002358-22-6 (RS)-S-(3-aminophenyl)-N-(isopropylcarbamoyl)-S-methylsulfoximide 
• 942410-78-8 (RS)-S-(3-nitrophenyl)-N-(ethoxycarbonyl)-S-methyl sulfoximide 
• 1352310-83-8 C₂₅H₃₅NO₆S 
• 22133-02-4 imino(methyl)(3-nitrophenyl)-λ⁶-sulfanone 
• 2976-32-1 1-methanesulfonyl-3-nitro-benzene 

Relevant articles and documents

Organocatalytic sulfoxidation

Treatment of a sulfide with a catalytic amount of a 1,3-diketone in the presence of silica sulfuric acid as a co-catalyst and hydrogen peroxide (50% aq) as the stoichiometric oxidant leads to the corresponding sulfoxide product. The reaction is effective for diaryl, aryl-alkyl and dialkyl sulfides and is tolerant of oxidisable and acid sensitive functional groups. Investigations have shown that the tris-peroxide 2, formed on reaction of pentane-2,4-dione with hydrogen peroxide under acidic reaction conditions, can oxidise two equivalents of sulfide using the exocyclic peroxide groups whereas the endocyclic peroxide remains intact. Calculations provide a mechanism consistent with experimental observations and suggest the reaction proceeds via an initial acid catalysed ring opening of a protonated tris-peroxide prior to oxygen transfer to a sulfur nucleophile.

Synthesis of: N -alkylated 2-pyridones through Pummerer type reactions of activated sulfoxides and 2-fluoropyridine derivatives

N-Alkylated 2-pyridone products were obtained in good to excellent yields through a one-pot procedure involving either normal or interrupted Pummerer reactions between triflic anhydride activated sulfoxides and 2-fluoropyridine derivatives, followed by hydrolysis. This is a rare case that uses 2-fluoropyridine as a nucleophile in Pummerer type reactions.

Oxidation of organic sulfides by imidazolium fluorochromate: A kinetic and mechanistic approach

The oxidation of organic sulfides by imidazolium fluorochromate resulted in the formation of the corresponding sulfoxides. The reaction is first order with respect to imidazolium fluorochromate. A Michaelis-Menten type kinetics was observed with respect t