32357-75-8Relevant articles and documents
Inhibitors of tick-borne flavivirus reproduction from structure-based virtual screening
Osolodkin, Dmitry I.,Kozlovskaya, Liubov I.,Dueva, Evgenia V.,Dotsenko, Victor V.,Rogova, Yulia V.,Frolov, Konstantin A.,Krivokolysko, Sergey G.,Romanova, Ekaterina G.,Morozov, Alexey S.,Karganova, Galina G.,Palyulin, Vladimir A.,Pentkovski, Vladimir M.,Zefirov, Nikolay S.
supporting information, p. 869 - 874 (2013/10/01)
Flaviviruses form a large family of enveloped viruses affecting millions of people over the world. To date, no specific therapy was suggested for the infected people, making the treatment exclusively symptomatic. Several attempts were performed earlier for the design of fusion inhibitors for mosquito-borne flaviviruses, whereas for the tick-borne flaviviruses such design had not been performed. We have constructed homology models of envelope glycoproteins of tick-transmitted flaviviruses with the detergent binding pocket in the open state. Molecular docking of substituted 1,4-dihydropyridines and pyrido[2,1-b][1,3,5]thiadiazines was made against these models, and 89 hits were selected for the in vitro experimental evaluation. Seventeen compounds showed significant inhibition against tick-borne encephalitis virus, Powassan virus, or Omsk hemorrhagic fever virus in the 50% plaque reduction test in PEK cells. These compounds identified through rational design are the first ones possessing reproduction inhibition activity against tick-borne flaviviruses.
Compounds for the treatment of pain
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, (2008/06/13)
This invention provides methods of treating pain, urinary incontinence and other abnormalities mediated by a NPFF receptor, which comprises administering to a subject a therapeutically effective amount of a chemical compound which acts at the NPFF1 receptor, the NPFF2 receptor, or at both the NPFF1 and NPFF2 receptors.
