3128-32-3

Basic information

• Product Name: 2-Propenoic acid, hydrazide
• Synonyms: 2-Propenoic acid, hydrazide
• CAS NO: 3128-32-3
• Molecular Formula: C₃H₆N₂O
• Molecular Weight: 86.09254
• Mol File: 3128-32-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propenoic acid, hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, hydrazide(3128-32-3)
• EPA Substance Registry System: 2-Propenoic acid, hydrazide(3128-32-3)

Safety Data

• Hazardous Substances Data: 3128-32-3(Hazardous Substances Data)

Usage

Description

2-Propenoic acid, hydrazide, also known as acryloyl hydrazide, is a chemical compound characterized by the molecular formula C3H6N2O. It presents as a colorless to light yellow solid and is recognized for its utility as a reagent in organic chemical reactions. Its versatility extends to applications as a crosslinking agent in polymeric materials and as a component in the synthesis of pharmaceuticals and agrochemicals. 2-Propenoic acid, hydrazide's potential in drug development for treating various diseases is an area of ongoing research, underscoring its significance in the scientific community. However, due to its potential health and environmental risks, careful handling is imperative.

Uses

Used in Organic Chemical Reactions:
2-Propenoic acid, hydrazide is used as a reagent for its ability to participate in a variety of organic chemical reactions, facilitating the synthesis of new compounds and contributing to the advancement of organic chemistry.
Used in Polymer Production:
In the polymer industry, 2-Propenoic acid, hydrazide is utilized as a crosslinking agent, which enhances the properties of polymeric materials by creating a network structure that improves their stability and performance.
Used in Pharmaceutical Synthesis:
2-Propenoic acid, hydrazide is employed as a key component in the synthesis of pharmaceutical compounds, playing a crucial role in the development of new drugs for the treatment of various diseases.
Used in Agrochemical Development:
2-Propenoic acid, hydrazide is also used in the synthesis of agrochemicals, contributing to the creation of products that can improve agricultural yields and protect crops from pests and diseases.
Used in Drug Development Research:
2-Propenoic acid, hydrazide is studied for its potential use in the development of drugs, indicating its importance in the search for novel therapeutic agents to combat a range of medical conditions.

Synthetic route

acrylic acid cyanomethyl ester (13818-40-1) → acryloyl hydrazine (3128-32-3)

Conditions	Yield
With chloroform; hydrazine hydrate

potassium acrylate (10192-85-5) → acryloyl hydrazine (3128-32-3)

Conditions	Yield
(i) Py, ClCO2Et, CH2Cl2, (ii) N2H4*H2O; Multistep reaction;

acryloyl-ethoxycarbonyl oxide → acryloyl hydrazine (3128-32-3)

Conditions	Yield
With dichloromethane; hydrazine hydrate

ethyl acrylate (140-88-5) → acryloyl hydrazine (3128-32-3)

Conditions	Yield
With hydrazine hydrate In ethanol Microwave irradiation;
With hydrazine hydrate In tetrahydrofuran at 80℃; for 1h;

acryloyl hydrazine (3128-32-3) + 7-diethylamino-9,9-dimethylfluorene-2-carbaldehyde (1208005-62-2) → C23H27N3O

Conditions	Yield
In ethanol at 80℃; Inert atmosphere;	60%

formaldehyd (50-00-0) + acryloyl hydrazine (3128-32-3) → N',N'-dimethylacetohydrazide (6233-04-1)

Conditions	Yield
palladium In water; benzene

acryloyl hydrazine (3128-32-3) + cadmium(II) chloride (10108-64-2) → Cd(CH2CHCONNH2)Cl(H2O)

Conditions	Yield
With 2,2'-azobisisobutyronitrile In N,N-dimethyl-formamide refluxing anhyd. Cd-salt with acryloyl hydrazine in DMF and 2,2'-azobisisobutyronitrile as initiator for 8 h; poured into a large excess of distilled water containing dilute HCl, filtered, washed with water, dried in a vac. oven at 40°C for several days; elem. anal.;

acryloyl hydrazine (3128-32-3) + iron(III) chloride (7705-08-0) → (Fe(CH2CHCONHNH2)Cl3)2

Conditions	Yield
With 2,2'-azobisisobutyronitrile In N,N-dimethyl-formamide refluxing anhyd. Fe-salt with acryloyl hydrazine in DMF and 2,2'-azobisisobutyronitrile as initiator for 8 h; poured into a large excess of distilled water containing dilute HCl, filtered, washed with water, dried in a vac. oven at 40°C for several days; elem. anal.;

acryloyl hydrazine (3128-32-3) + copper diacetate (142-71-2) → Cu(CH2CHCONHNH2)(CH3CO2)2

Conditions	Yield
With 2,2'-azobisisobutyronitrile In N,N-dimethyl-formamide refluxing anhyd. Cu-salt with acryloyl hydrazine in DMF and 2,2'-azobisisobutyronitrile as initiator for 8 h; poured into a large excess of distilled water containing dilute HCl, filtered, washed with water, dried in a vac. oven at 40°C for several days; elem. anal.;

acryloyl hydrazine (3128-32-3) + uranyl acetate → UO2(CH2CHCONNH2)2(H2O)2

Conditions	Yield
With 2,2'-azobisisobutyronitrile In N,N-dimethyl-formamide refluxing anhyd. UO2-salt with acryloyl hydrazine in DMF and 2,2'-azobisisobutyronitrile as initiator for 8 h; poured into a large excess of distilled water containing dilute HCl, filtered, washed with water, dried in a vac. oven at 40°C for several days; elem. anal.;

acryloyl hydrazine (3128-32-3) + cobalt(II) chloride (7646-79-9) → Co(CH2CHCONNH2)2(H2O)2

Conditions	Yield
With 2,2'-azobisisobutyronitrile In N,N-dimethyl-formamide refluxing anhyd. Co-salt with acryloyl hydrazine in DMF and 2,2'-azobisisobutyronitrile as initiator for 8 h; poured into a large excess of distilled water containing dilute HCl, filtered, washed with water, dried in a vac. oven at 40°C for several days; elem. anal.;

acryloyl hydrazine (3128-32-3) + copper dichloride → Cu(CH2CHCONNH2)Cl(H2O)

Conditions	Yield
With 2,2'-azobisisobutyronitrile In N,N-dimethyl-formamide refluxing anhyd. Cu-salt with acryloyl hydrazine in DMF and 2,2'-azobisisobutyronitrile as initiator for 8 h; poured into a large excess of distilled water containing dilute HCl, filtered, washed with water, dried in a vac. oven at 40°C for several days; elem. anal.;

acryloyl hydrazine (3128-32-3) + nickel dichloride → Ni(2+)*CH2CHCONHNH2*2Cl(1-)=Ni(CH2CHCONHNH2)Cl2

Conditions	Yield
With 2,2'-azobisisobutyronitrile In N,N-dimethyl-formamide refluxing anhyd. Ni-salt with acryloyl hydrazine in DMF and 2,2'-azobisisobutyronitrile as initiator for 8 h; poured into a large excess of distilled water containing dilute HCl, filtered, washed with water, dried in a vac. oven at 40°C for several days; elem. anal.;

acryloyl hydrazine (3128-32-3) + pyridine-2-carboxamidine hydrochloride (51285-26-8, 61097-49-2) → 2-(3-vinyl-1H-1,2-4-triazol-5-yl)pyridine

Conditions	Yield
With sodium hydroxide In tetrahydrofuran at 80℃; for 1h;

Upstream product

• 10192-85-5 potassium acrylate 
• 140-88-5 ethyl acrylate 
• 13818-40-1 acrylic acid cyanomethyl ester 

Downstream Products

• 6233-04-1 N',N'-dimethylacetohydrazide 

Relevant articles and documents

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