30737-83-8 Usage
Description
D-glucose-2-d1, also known as [2,2,3,3-2H4]-D-glucose, is a stable isotope-labeled form of glucose that is specifically labeled with deuterium at the C-2 position. This unique characteristic enables researchers to track and quantify glucose metabolism in biological systems, providing valuable insights into glucose uptake, utilization, and production in various tissues and organs. D-glucose-2-d1 is widely used in metabolic and stable isotope tracer studies, often in conjunction with mass spectrometry and other analytical techniques, to investigate metabolic pathways and fluxes in both normal and disease states.
Uses
Used in Metabolic Studies:
D-glucose-2-d1 is used as a metabolic tracer for studying glucose metabolism in biological systems. Its deuterium labeling at the C-2 position allows for the tracking and quantification of glucose uptake, utilization, and production in various tissues and organs.
Used in Analytical Techniques:
D-glucose-2-d1 is used as a stable isotope-labeled compound in conjunction with mass spectrometry and other analytical techniques. This enables researchers to provide detailed insights into glucose metabolism and its regulation in normal and disease states.
Used in Investigating Metabolic Pathways and Fluxes:
D-glucose-2-d1 is used as a tool to investigate metabolic pathways and fluxes in cells. Its stable isotope labeling allows for the precise measurement of glucose metabolism, helping researchers understand the complex interplay of metabolic processes in both health and disease.
Used in Research on Normal and Disease States:
D-glucose-2-d1 is used as a research compound to study glucose metabolism in both normal and disease states. Its ability to be tracked and quantified in biological systems provides valuable information on the regulation of glucose metabolism and its role in various diseases, such as diabetes and cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 30737-83-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,7,3 and 7 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 30737-83:
(7*3)+(6*0)+(5*7)+(4*3)+(3*7)+(2*8)+(1*3)=108
108 % 10 = 8
So 30737-83-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5?,6?/m1/s1/i5D
30737-83-8Relevant articles and documents
Glucose is a precursor of 1-deoxynojirimycin and 1-deoxymannonojirimycin in Streptomyces subrutilus
Hardick, David J.,Hutchinson, David W.,Trew, Sally J.,Wellington, Elizabeth M. H.
, p. 6285 - 6296 (2007/10/02)
Streptomyces subrutilus ATCC 27467, when grown on a glucose-containing soyabean medium, produces both 1-deoxymannonojirimycin (DMJ) and 1-deoxynojirimycin (DNJ) in its culture medium. When 1- or 2-[2H]-D-glucose is used, the deuterium label appears at C6 in both alkaloids and the labelling pattern suggests that the first step in the biosynthesis of both DNJ and DMJ is a glucose to fructose isomerisation. Studies with 5-2H]- and 6,6-2H2-D-glucose indicate that oxidation of the 6-position of the glucose/fructose occurs during the biosynthesis and that mannonojirimycin is the first aminosugar to be formed. Mannonojirimycin can then undergo dehydration and reduction to DMJ. Alternatively, epimerisation of mannonojirimycin can occur at C2 to give nojirimycin which is then dehydrated and reduced to DNJ.
