30388-70-6

Basic information

• Product Name: Benzene,1,1-sulfinylbis[2-nitro- (9CI)
• Synonyms: Benzene,1,1-sulfinylbis[2-nitro- (9CI);Bis(o-nitrophenyl) sulfoxide;NSC 400306;Benzene,1,1'-sulfinylbis[2-nitro-
• CAS NO: 30388-70-6
• Molecular Formula: C₁₂H₈N₂O₅S
• Molecular Weight: 292.26732
• Mol File: 30388-70-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 524.2 °C at 760 mmHg
• Flash Point: 270.8 °C
• Appearance: /
• Density: 1.58 g/cm³
• CAS DataBase Reference: Benzene,1,1-sulfinylbis[2-nitro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene,1,1-sulfinylbis[2-nitro- (9CI)(30388-70-6)
• EPA Substance Registry System: Benzene,1,1-sulfinylbis[2-nitro- (9CI)(30388-70-6)

Safety Data

• Hazardous Substances Data: 30388-70-6(Hazardous Substances Data)

Usage

General Description

Benzene,1,1-sulfinylbis[2-nitro- (9CI) is a chemical compound that consists of a benzene ring with two nitro (NO2) groups attached to it, as well as a sulfinyl (SO) group bridging them. Benzene,1,1-sulfinylbis[2-nitro- (9CI) is a type of nitrobenzene derivative and is used in the chemical industry as an intermediate for the synthesis of various organic compounds and dyes. It is also known to have some level of toxicity and is classified as a potential carcinogen, with exposure to high levels being harmful to human health. Due to its potential hazards, proper safety measures and protective equipment should be used when handling this chemical.

Upstream product

• 139-66-2 diphenyl sulfide 
• 577-19-5 2-nitrophenyl bromide 
• 528-29-0 1,2-Dinitrobenzene 
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• 4875-10-9 o-nitrothiophenol 
• 7697-37-2 nitric acid 
• 22100-66-9 bis-(2-nitro-phenyl)-sulfide 

Downstream Products

• 14665-52-2 2,2'-dinitrodiphenyl sulfone 
• 1156-50-9 4-nitrophenyl sulfone 

Relevant articles and documents

2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1

A series of 2-amino-5-arylthiobenzonitriles (1) was found to be active against HIV-1. Structural modifications led to the sulfoxides (2) and sulfones (3). The sulfoxides generally showed antiviral activity against HIV-1 similar to that of 1. The sulfones, however, were the most potent series of analogues, a number having activity against HIV-1 in the nanomolar range. Structural-activity relationship (SAR) studies suggested that a meta substituent, particularly a meta methyl substituent, invariably increased antiviral activities. However, optimal antiviral activities were manifested by compounds where both meta groups in the arylsulfonyl moiety were substituted and one of the substituents was a methyl group. Such a disubstitution led to compounds 3v, 3w, 3x, and 3y having IC50 values against HIV-1 in the low nanomolar range. When gauged for their broad-spectrum antiviral activity against key non-nucleoside reverse transcriptase inhibitor (NNRTI) related mutants, all the di-meta-substituted sulfones 3u-z and the 2-naphthyl analogue 3ee generally showed single-digit nanomolar activity against the V106A and P236L strains and submicromolar to low nanomolar activity against strains E138K, V108I, and Y188C. However, they showed a lack of activity against the K103N and Y181C mutant viruses. The elucidation of the X-ray crystal structure of the complex of 3v (739W94) in HIV-1 reverse transcriptase showed an overlap in the binding domain when compared with the complex of nevirapine in HIV-1 reverse transcriptase. The X-ray structure allowed for the rationalization of SAR data and potencies of the compounds against the mutants.