301359-45-5

Basic information

• Product Name: 5-PyriMidinecarboxylic acid,4-(2-chlorophenyl)-1,2,3,4-tetrahydro-6-Methyl-2-thioxo-, ethyl ester
• Synonyms: 5-PyriMidinecarboxylic acid,4-(2-chlorophenyl)-1,2,3,4-tetrahydro-6-Methyl-2-thioxo-, ethyl ester;Ethyl 4-(2-chlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• CAS NO: 301359-45-5
• Molecular Formula: C₁₄H₁₅ClN₂O₂S
• Molecular Weight: 310.7991
• Mol File: 301359-45-5.mol
• Article Data: 38

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-PyriMidinecarboxylic acid,4-(2-chlorophenyl)-1,2,3,4-tetrahydro-6-Methyl-2-thioxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PyriMidinecarboxylic acid,4-(2-chlorophenyl)-1,2,3,4-tetrahydro-6-Methyl-2-thioxo-, ethyl ester(301359-45-5)
• EPA Substance Registry System: 5-PyriMidinecarboxylic acid,4-(2-chlorophenyl)-1,2,3,4-tetrahydro-6-Methyl-2-thioxo-, ethyl ester(301359-45-5)

Safety Data

• Hazardous Substances Data: 301359-45-5(Hazardous Substances Data)

Usage

General Description

The chemical "5-PyriMidinecarboxylic acid, 4-(2-chlorophenyl)-1,2,3,4-tetrahydro-6-Methyl-2-thioxo-, ethyl ester" is an organic compound with the molecular formula C16H18ClN3O2S. It is an ethyl ester derivative of a 4-(2-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid. 5-PyriMidinecarboxylic acid,4-(2-chlorophenyl)-1,2,3,4-tetrahydro-6-Methyl-2-thioxo-, ethyl ester has potential applications in the field of pharmaceuticals and agrochemicals due to its structural and chemical properties. It may be used for the synthesis of various pharmaceutical drugs and can also be employed as an intermediate in organic synthesis. Additionally, it possesses certain biological activities that make it a promising candidate for further research and development in the pharmaceutical industry.

Upstream product

• 1147550-11-5 ammonium thiocyanate 
• 141-97-9 ethyl acetoacetate 
• 89-98-5 2-chloro-benzaldehyde 
• 17849-38-6 2-Chlorobenzyl alcohol 
• 17356-08-0 thiourea 

Downstream Products

• 455927-22-7 4-(2-chlorophenyl)-6-methyl-N-4-fluoro phenyl-2-thioxo-1,2,3,4-tetrahydro pyrimidine-5-carboxamide 
• 313276-45-8 C₁₆H₁₅ClN₂O₃S 
• 1426661-08-6 C₂₈H₂₆Cl₂N₄O₄S 
• 1425352-64-2 ethyl 5-(2-chlorophenyl)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate hydrochloride 
• 361481-37-0 C₁₄H₁₄ClN₅O₂ 
• 1034918-24-5 6-ethoxycarbonyl-7-methyl-5-(2-chlorophenyl)-5H-thiazolo[3,2-a]pyrimidine 

Relevant articles and documents

Synthesis and characterization of sulfonated-phenylacetic acid coated Fe3O4 nanoparticles as a novel acid magnetic catalyst for Biginelli reaction

Abstract In this paper, we wish to report the synthesis and characterization of sulfonated-phenylacetic acid coated on Fe3O 4 nanoparticles by a simple method. This catalyst was effectively employed as a novel acid magnetic catalyst

Synthesis of novel calcium channel blockers with ACE2 inhibition and dual antihypertensive/anti-inflammatory effects: A possible therapeutic tool for COVID-19

Hypertension has been recognized as one of the most frequent comorbidities and risk factors for the seriousness and adverse consequences in COVID-19 patients. 3,4-dihydropyrimidin-2(1H) ones have attracted researchers to be synthesized via Beginilli reaction and evaluate their antihypertensive activities as bioisosteres of nifedipine a well-known calcium channel blocker. In this study, we report synthesis of some bioisosteres of pyrimidines as novel CCBs with potential ACE2 inhibitory effect as antihypertensive agents with protective effect against COVID-19 infection by suppression of ACE2 binding to SARS-CoV-2 Spike RBD. All compounds were evaluated for their antihypertensive and calcium channel blocking activities using nifedipine as a reference standard. Furthermore, they were screened for their ACE2 inhibition potential in addition to their anti‐inflammatory effects on LPS-stimulated THP‐1 cells. Most of the tested compounds exhibited significant antihypertensive activity, where compounds 7a, 8a and 9a exhibited the highest activity compared to nifedipine. Moreover, compounds 4a,b, 5a,b, 7a,b, 8a,c and 9a showed promising ACE2:SARS-CoV-2 Spike RBD inhibitory effect. Finally, compounds 5a, 7b and 9a exerted a promising anti-inflammatory effect by inhibition of CRP and IL-6 production. Ultimately, compound 9a may be a promising antihypertensive candidate with anti-inflammatory and potential efficacy against COVID-19 via ACE2 receptor inhibition.

Access to Chiral Bisphenol Ligands (BPOL) through Desymmetrizing Asymmetric Ortho-Selective Halogenation

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Bis(p-sulfoanilino)triazine-functionalized silica-coated magnetite nanoparticles as an efficient and magnetically reusable nano-catalyst for Biginelli-type reaction

Abstract: The preparation of bis(p-sulfoanilino)triazine-functionalized silica-coated magnetite nanoparticles and their use as a novel magnetically separable nanocatalyst for the synthesis of various Biginelli adducts are presented. The materials were characterized by various microscopic and spectroscopic techniques such as scanning electron microscopy, vibrating sample magnetometer, X-ray powder diffraction, and FT-IR spectroscopy, etc. A series of 3,4-dihydropyrimidinones or thione products were conveniently prepared by this green protocol from the reactions of aromatic aldehydes with the 1,3-dicarbonyl compounds and urea or thiourea using the catalyst under solvent-free conditions. The present method is operationally simple and offers several advantages such as good to excellent yields, short reaction times, the absence of a solvent, and simple work-up. Moreover, the aforementioned nanocatalyst can be easily recovered from the reaction mixture with the assistance of an external magnetic field and reused several times without any loss of its catalytic activity.