3005-61-6

Basic information

• Product Name: N-benzoyl-L-phenylalanine methyl ester
• Synonyms: (S)-N-Benzoylphenylalanine methyl ester;Methyl (2S)-2-(benzoylamino)-3-phenylpropanoate;N-Benzoylphenylalanine methyl ester;methyl benzoyl-L-phenylalaninate;(S)-methyl 2-benzamido-3-phenylpropanoate;N-benzoyl-L-phenylalanine methyl ester;Methyl N-benzoyl-L-phenylalaninate;methyl (S)-2-(benzoylamino)-3-phenylpropanoate
• CAS NO: 3005-61-6
• Molecular Formula: C₁₇H₁₇NO₃
• Molecular Weight: 283.32178
• Mol File: 3005-61-6.mol
• Article Data: 81

Chemical Properties

• Melting Point: 83-85℃
• Appearance: solid or liquid
• Density: 1.161
• CAS DataBase Reference: N-benzoyl-L-phenylalanine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzoyl-L-phenylalanine methyl ester(3005-61-6)
• EPA Substance Registry System: N-benzoyl-L-phenylalanine methyl ester(3005-61-6)

Safety Data

• Hazardous Substances Data: 3005-61-6(Hazardous Substances Data)

Usage

General Description

N-benzoyl-L-phenylalanine methyl ester is a chemical compound that consists of a benzoyl group, a phenylalanine amino acid, and a methyl ester group. It is commonly used in the field of pharmaceuticals and organic chemistry as a building block for the synthesis of various compounds, including peptide-based drugs and organic compounds. N-benzoyl-L-phenylalanine methyl ester has been studied for its potential use in drug delivery systems and as a precursor for the synthesis of bioactive molecules. Additionally, it has been explored for its potential biological activities, including anti-inflammatory and antioxidant properties. Overall, N-benzoyl-L-phenylalanine methyl ester is a versatile chemical compound with potential applications in pharmaceutical research and development.

Upstream product

• 67-56-1 methanol 
• 2566-22-5 N-benzoyl-L-phenylalanine 
• 5874-61-3 4-benzyl-2-phenyl-2-oxazolin-5-one 
• 17606-70-1 (4Z)-4-benzylidene-2-phenyl-1,3-oxazol-5(4H)-one 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 98-88-4 benzoyl chloride 
• 74923-17-4 methyl N-benzoylphenylalaninate 
• 27573-05-3 methyl ester of benzoylaminocinnamic acid 
• 23405-15-4 benzoic acid N-hydroxysuccinimide ester 
• 2566-22-5 DL-N-benzoylphenylalanine 
• 150-30-1 Phenylalanine 
• 91344-86-4 3-methoxy-3-oxoprop-1-en-1-yl benzoate 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 100-52-7 benzaldehyde 

Downstream Products

• 42807-45-4 N-benzyl-L-phenylalaninol 
• 23912-63-2 (S)-N-(1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)benzamide 
• 2566-22-5 N-benzoyl-L-phenylalanine 
• 23912-50-7 (S)-N-(1-Hydrazineyl-1-oxo-3-phenylpropan-2-yl)benzamide 
• 60142-77-0 N-(N-benzoyl-L-phenylalanyl)-L-tyrosine methyl ester 
• 934221-58-6 N-(N-benzoyl-L-phenylalanyl)-O-ethyl-L-tyrosine methyl ester 
• 934221-59-7 N-(N-benzoyl-L-phenylalanyl)-O-butyl-L-tyrosine methyl ester 
• 934221-66-6 sodium N-(N-benzoyl-L-phenylalanyl)-O-methyl-L-tyrosinate 
• 1338250-32-0 sodium N-(N-benzoyl-L-phenylalanyl)-O-ethyl-L-tyrosinate 
• 934221-61-1 sodium N-(N-benzoyl-L-phenylalanyl)-O-butyl-L-tyrosinate 
• 72150-35-7 Bz-Phe-NH₂ 
• 1208130-69-1 N-((S)-1-((S)-1-(hydroxyamino)-5-(3-nitroguanidino)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl) benzamide 

Relevant articles and documents

Part III. COD versus NBD precatalysts. Dramatic difference in the asymmetric hydrogenation of prochiral olefins with five-membered diphosphine Rh-hydrogenation catalysts

Induction periods in the asymmetric hydrogenation of prochiral olefins with five-membered chelates of the type [Rh(PP)(diolefin)]BF4 originate from the parallel-running hydrogenation of the prochiral substrate and the diolefin that enters the s

Insights into Fast Amide Couplings in Aqueous Nanomicelles

1-Ethyl-3-(3-(dimethylamino)propyl)-carbodiimide (EDC?HCl) has both lipophilic and hydrophilic regions, causing self-aggregation (also called nanoparticle formation) in an aqueous medium containing PS-750-M amphiphile. Kinetic and proton nuclear magnetic resonance studies were used to probe the effect of different organic bases on the potential nanoparticle formation of EDC?HCl. It also reveals why the pyridine base works better under micellar conditions. The methodology was examined on the multigram scale synthesis of bioactive molecules, where excellent reaction yields were obtained without product epimerization while maintaining a shorter reaction time.

Nickel-Catalyzed Asymmetric Hydrogenation of 2-Amidoacrylates

Earth-abundant nickel, coordinated with a suitable chiral bisphosphine ligand, was found to be an efficient catalyst for the asymmetric hydrogenation of 2-amidoacrylates, affording the chiral α-amino acid esters in quantitative yields and excellent enantioselectivity (up to 96 % ee). The active catalyst component was studied by NMR and HRMS, which helped us to realize high catalytic efficiency on a gram scale with a low catalyst loading (S/C=2000). The hydrogenated products could be simply converted into chiral α-amino acids, β-amino alcohols, and their bioactive derivatives. Furthermore, the catalytic mechanism was investigated using deuterium-labeling experiments and computational calculations.