2963-65-7

Basic information

• Product Name: 5-METHYL-2-PHENYL-1H-BENZO[D]IMIDAZOLE
• Synonyms: 1H-BENZIMIDAZOLE, 6-METHYL-2-PHENYL-;1H-BenziMidazole, 6-Methyl-2-phenyl-1H-BenziMidazole, 5-Methyl-2-phenyl- (9CI);5-Methyl-2-phenylbenziMidazole, 95%;5-Methyl-2-phenyl-1H-benzoimidazole;5-METHYL-2-PHENYL-1H-BENZO[D]IMIDAZOLE
• CAS NO: 2963-65-7
• Molecular Formula: C₁₄H₁₂N₂
• Molecular Weight: 208.26
• Mol File: 2963-65-7.mol
• Article Data: 160

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-METHYL-2-PHENYL-1H-BENZO[D]IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-2-PHENYL-1H-BENZO[D]IMIDAZOLE(2963-65-7)
• EPA Substance Registry System: 5-METHYL-2-PHENYL-1H-BENZO[D]IMIDAZOLE(2963-65-7)

Safety Data

• Hazardous Substances Data: 2963-65-7(Hazardous Substances Data)

Usage

Description

5-METHYL-2-PHENYL-1H-BENZO[D]IMIDAZOLE is a benzimidazole derivative with the molecular formula C16H14N2. It features a methyl group attached to the 5th carbon and a phenyl group attached to the 2nd carbon of the benzene ring. This chemical compound has been studied for its potential medicinal properties and has demonstrated diverse biological activities, such as anti-cancer, anti-inflammatory, and anti-microbial effects. Its unique structural features and potential therapeutic applications have garnered significant interest in the scientific community.

Uses

Used in Pharmaceutical Industry:
5-METHYL-2-PHENYL-1H-BENZO[D]IMIDAZOLE is used as a pharmaceutical candidate for its potential medicinal properties. It has shown to exhibit anti-cancer, anti-inflammatory, and anti-microbial effects, making it a promising compound for the development of new drugs to treat various diseases and conditions.
Used in Cancer Treatment:
In the field of oncology, 5-METHYL-2-PHENYL-1H-BENZO[D]IMIDAZOLE is used as an anti-cancer agent. Its potential to target and inhibit the growth of cancer cells has positioned it as a candidate for further research and development in cancer treatment.
Used in Anti-Inflammatory Applications:
5-METHYL-2-PHENYL-1H-BENZO[D]IMIDAZOLE is utilized as an anti-inflammatory agent due to its ability to reduce inflammation. This property makes it a candidate for the treatment of various inflammatory conditions and diseases.
Used in Anti-Microbial Applications:
In the realm of microbiology, 5-METHYL-2-PHENYL-1H-BENZO[D]IMIDAZOLE is employed as an anti-microbial agent. Its effectiveness against certain microorganisms suggests potential use in the development of new antimicrobial drugs to combat infections.
Used in Drug Development:
5-METHYL-2-PHENYL-1H-BENZO[D]IMIDAZOLE is used in the research and development of new pharmaceutical drugs. Its unique structural features and demonstrated biological activities make it a valuable compound for creating innovative and effective medications.

Upstream product

• 100-52-7 benzaldehyde 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 636-24-8 4-Methyl-benzene-1,2-diamine; hydrochloride 
• 100-47-0 benzonitrile 
• 65-85-0 benzoic acid 
• 36954-12-8 N-(3-methylphenyl)-benzylamine oxime 
• 98-09-9 benzenesulfonyl chloride 
• 1859-00-3 N-(4-methylphenyl)benzamidine 
• 591-50-4 iodobenzene 
• 201230-82-2 carbon monoxide 
• 98-88-4 benzoyl chloride 
• 7647-01-0 hydrogenchloride 
• 5467-06-1 N,N'-(4-methyl-o-phenylene)-bis-benzamide 
• 53476-33-8 2'-amino-4'-methylbenzanilide 

Downstream Products

• 24781-11-1 1-benzyl-6-methyl-2-phenyl-1H-benzo[d]imidazole 
• 1313402-11-7 5-methyl-1-methanesulphinylmethyl-2-phenyl-1H-benzimidazole 
• 1313401-96-5 5-methyl-1-methylsulphanylmethyl-2-phenyl-1H-benzimidazole 
• 66630-70-4 2-phenyl-1H-1,3-benzimidazole-5-carboxylic acid 

Relevant articles and documents

AN EFFICIENT PREPARATION OF 4-ARYLMETHYLISOXAZOL-5-ONES BY SELECTIVE REDUCTION OF THE 4-ARYLMETHYLENEISOXAZOL-5-ONES

An efficient selective reduction of the exocyclic double bond of the 4-arylmethyleneisoxazol-5-ones with o-phenylenediamines and aldehydes is described. 4-arylmethylisoxazol-5-ones are produced in high yields together with comparable quantities of benzimidazoles.

One-Pot Transformation of Lignin and Lignin Model Compounds into Benzimidazoles

It is a challenging task to simultaneously achieve selective depolymerization and valorization of lignin due to their complex structure and relatively stable bonds. We herein report an efficient depolymerization strategy that employs 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as oxidant/catalyst to selectively convert different oxidized lignin models to a wide variety of 2-phenylbenzimidazole-based compounds in up to 94 % yields, by reacting with o-phenylenediamines with varied substituents. This method could take full advantage of both Cβ and/or Cγ atom in lignin structure to furnish the desirable products instead of forming byproducts, thus exhibiting high atom economy. Furthermore, this strategy can effectively transform both the oxidized hardwood (birch) and softwood (pine) lignin into the corresponding degradation products in up to 45 wt% and 30 wt%, respectively. Through a “one-pot” process, we have successfully realized the oxidation/depolymerization/valorization of natural birch lignin at the same time and produced the benzimidazole derivatives in up to 67 wt% total yields.

Preparation method of 2-substituted benzimidazole compound

The invention discloses a preparation method of a 2-substituted benzimidazole compound, and belongs to the field of synthesis of benzimidazole compounds. The 2-substituted benzimidazole compound is synthesized in an organic solvent by taking an o-nitroaniline compound, aromatic aldehyde, o-dinitrobenzene and aromatic aldehyde as raw materials and taking Co particles wrapped by a nitrogen-doped carbon material as a catalyst. According to the method, the 2-substituted benzimidazole compound can be prepared at room temperature, the reaction conditions are mild, the yield is as high as 95%, the selectivity is as high as 99%, and the method is economical, environmentally friendly and wide in substrate applicability. The used catalyst is easy to prepare, low in cost and good in reusability, canbe separated by utilizing magnetism, and is convenient to recover, so that the method has a relatively strong industrial application prospect.